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Protein

L-lactate dehydrogenase

Gene

TDEL0H04490

Organism
Torulaspora delbrueckii (strain ATCC 10662 / CBS 1146 / NBRC 0425 / NCYC 2629 / NRRL Y-866) (Yeast) (Candida colliculosa)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.UniRule annotation

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase (TDEL0C07030), L-lactate dehydrogenase (TDEL0H04490), L-lactate dehydrogenase (TDEL0F00140)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei91SubstrateUniRule annotation1
Binding sitei123SubstrateUniRule annotation1
Binding sitei154SubstrateUniRule annotation1
Active sitei178Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandNADUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00554; UER00611.

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenaseUniRule annotation (EC:1.1.1.27UniRule annotation)
Gene namesi
Name:TDEL0H04490Imported
ORF Names:TDEL_0H04490Imported
OrganismiTorulaspora delbrueckii (strain ATCC 10662 / CBS 1146 / NBRC 0425 / NCYC 2629 / NRRL Y-866) (Yeast) (Candida colliculosa)Imported
Taxonomic identifieri1076872 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeTorulaspora
Proteomesi
  • UP000005627 Componenti: Chromosome 8

Subcellular locationi

Interactioni

Protein-protein interaction databases

STRINGi4950.XP_003683519.1.

Structurei

3D structure databases

ProteinModelPortaliG9A0B4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 145Ldh_1_NInterPro annotationAdd BLAST138
Domaini148 – 311Ldh_1_CInterPro annotationAdd BLAST164

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.UniRule annotation

Phylogenomic databases

InParanoidiG9A0B4.
KOiK00016.
OrthoDBiEOG092C3G32.

Family and domain databases

Gene3Di3.90.110.10. 1 hit.
HAMAPiMF_00488. Lactate_dehydrog. 1 hit.
InterProiView protein in InterPro
IPR001557. L-lactate/malate_DH.
IPR011304. L-lactate_DH.
IPR018177. L-lactate_DH_AS.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR036291. NAD(P)-bd_dom_sf.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01771. L-LDH-NAD. 1 hit.
PROSITEiView protein in PROSITE
PS00064. L_LDH. 1 hit.

Sequencei

Sequence statusi: Complete.

G9A0B4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSHTCAKVA IIGAGQVGST TAYTLLLSNL VAEVVLIDVD KRKVEGQFMD
60 70 80 90 100
LNHAAPLTKE SRFSAGDYES CAGAAVVIVT GGANQKPGQT RMELAARNVK
110 120 130 140 150
IMQEIIPKIV KYAPNAILLI ATNPVDVLTY ASYKLSGFPA SKVIGSGTVL
160 170 180 190 200
DSARLQHNLS KHFNLSSESV NAFIIGEHGD SGVPVWSLAE IAGMKVEDYC
210 220 230 240 250
KQSKREFDPK ILIGMYEETR DAAAYIIERK GYTNFGIAAG LARIVRAILR
260 270 280 290 300
DEGALLTVST VNEHYGMKDL SLSVPTRVDR NGAQHVVDLL LDDKELKLIK
310
ESGHKIKSAC DELGI
Length:315
Mass (Da):33,988
Last modified:February 22, 2012 - v1
Checksum:iA09B93531E8A05E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE616749 Genomic DNA. Translation: CCE94308.1.
RefSeqiXP_003683519.1. XM_003683471.1.

Genome annotation databases

EnsemblFungiiCCE94308; CCE94308; TDEL_0H04490.
GeneIDi11501718.
KEGGitdl:TDEL_0H04490.

Similar proteinsi

Entry informationi

Entry nameiG9A0B4_TORDC
AccessioniPrimary (citable) accession number: G9A0B4
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: November 22, 2017
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported