ID   G8ZY51_TORDE            Unreviewed;       969 AA.
AC   G8ZY51;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   27-MAR-2024, entry version 58.
DE   RecName: Full=DNA ligase {ECO:0000256|RuleBase:RU000617};
DE            EC=6.5.1.1 {ECO:0000256|RuleBase:RU000617};
GN   Name=TDEL0G04510 {ECO:0000313|EMBL:CCE93818.1};
GN   ORFNames=TDEL_0G04510 {ECO:0000313|EMBL:CCE93818.1};
OS   Torulaspora delbrueckii (Yeast) (Candida colliculosa).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Torulaspora.
OX   NCBI_TaxID=4950 {ECO:0000313|EMBL:CCE93818.1, ECO:0000313|Proteomes:UP000005627};
RN   [1] {ECO:0000313|EMBL:CCE93818.1, ECO:0000313|Proteomes:UP000005627}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10662 / CBS 1146 / NBRC 0425 / NCYC 2629 / NRRL Y-866
RC   {ECO:0000313|Proteomes:UP000005627};
RX   PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA   Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA   Wolfe K.H.;
RT   "Evolutionary erosion of yeast sex chromosomes by mating-type switching
RT   accidents.";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-
CC         (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP +
CC         diphosphate.; EC=6.5.1.1; Evidence={ECO:0000256|ARBA:ARBA00034003,
CC         ECO:0000256|RuleBase:RU000617};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC       {ECO:0000256|ARBA:ARBA00007572, ECO:0000256|RuleBase:RU004196}.
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DR   EMBL; HE616748; CCE93818.1; -; Genomic_DNA.
DR   RefSeq; XP_003683029.1; XM_003682981.1.
DR   AlphaFoldDB; G8ZY51; -.
DR   STRING; 1076872.G8ZY51; -.
DR   GeneID; 11505191; -.
DR   KEGG; tdl:TDEL_0G04510; -.
DR   eggNOG; KOG0966; Eukaryota.
DR   HOGENOM; CLU_004844_1_1_1; -.
DR   InParanoid; G8ZY51; -.
DR   Proteomes; UP000005627; Chromosome 7.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:InterPro.
DR   GO; GO:0051103; P:DNA ligation involved in DNA repair; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd07903; Adenylation_DNA_ligase_IV; 1.
DR   CDD; cd07968; OBF_DNA_ligase_IV; 1.
DR   Gene3D; 3.40.50.10190; BRCT domain; 2.
DR   Gene3D; 1.10.3260.10; DNA ligase, ATP-dependent, N-terminal domain; 1.
DR   Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR   InterPro; IPR044125; Adenylation_DNA_ligase_IV.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR000977; DNA_ligase_ATP-dep.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR   InterPro; IPR036599; DNA_ligase_N_sf.
DR   InterPro; IPR029710; LIG4.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   NCBIfam; TIGR00574; dnl1; 1.
DR   PANTHER; PTHR45997; DNA LIGASE 4; 1.
DR   PANTHER; PTHR45997:SF1; DNA LIGASE 4; 1.
DR   Pfam; PF16589; BRCT_2; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   SMART; SM00292; BRCT; 1.
DR   SUPFAM; SSF52113; BRCT domain; 2.
DR   SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR   PROSITE; PS50172; BRCT; 2.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS00333; DNA_LIGASE_A2; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU000617};
KW   DNA damage {ECO:0000256|RuleBase:RU000617};
KW   DNA recombination {ECO:0000256|ARBA:ARBA00023172,
KW   ECO:0000256|RuleBase:RU000617}; DNA repair {ECO:0000256|RuleBase:RU000617};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU000617};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU000617}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005627};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          396..510
FT                   /note="ATP-dependent DNA ligase family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50160"
FT   DOMAIN          704..803
FT                   /note="BRCT"
FT                   /evidence="ECO:0000259|PROSITE:PS50172"
FT   DOMAIN          864..966
FT                   /note="BRCT"
FT                   /evidence="ECO:0000259|PROSITE:PS50172"
FT   REGION          1..30
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..27
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   969 AA;  111242 MW;  BE41935B409BD40B CRC64;
     MESAEILTST HEVSQELQES ESTEKAPPNF APSPDFIWLC EELFVKLEDV QRQGREHLGN
     KPLSVRYYEV ISHFIRLWRK TVGNNIFPAL VLSLPYRDRR IYNIKDYTLV KAICSYLALP
     KQSATEKRLL KWKRRATRGV RLSNFCVEEI RKRKSEPSPG RRITIDKLNE CLDHLVEERN
     AKGGFKGLSD SPTFNFCLQN MSFIELRFFF DIVLKNRVIG GQEHKLLNCW HPDALDYLSV
     VSDLETVASR LWDPEHRLRR DDLSINLGYA FVPQLAKKMT ISYEKICTKL NNDFLIEEKM
     DGERIQVHYM DYGAKIRFLS RRGVDYTQLY GENLQSGTVA NYLNFDSNVR DCVLDGEMIT
     FDTDRNVVLP FGMVKSSARQ ALSTEGICSQ GHRPMLMVLD LVYLNGVSLI KLPLYQRKEF
     LNRVLKPCPH AVEILPYVRC SEHTAIRKSL EKSISMGSEG IVLKSYKARY EIGARNDYWI
     KVKPEYLEQF GENLDLVIIG RTPGKKDSLM CGLAVYEGEE DLNEIEAKRE SAIVNLDSEG
     DELDDTDGKK IIKYFISFCV IANGISQQEF KEIDRKTRGA WVKSDQRLPS ADLLRFGSKI
     PEEWIDPKNS IMLEVKARSL DNTESSKKKF AAGCTLHGGY CRRIRDDKDW TGCYSFSELW
     QERLHKSSTG VGSFNKQYSK KMKSKKRKID PFSGQAAKKH DVFDSTNIFK GLQFYVLSDY
     IDVSRNVRIT KSEFDDLILQ NSGKLVRNLI SKHHSESQFR IISGKYTAEC RALIERGYDI
     LSPQWILDCI RNRMVVKLEP RHCFNVSSEL MTIVNGRVDE YGDSFVNPIT EQQLDNLIDT
     NMKQTEPNLM REANSELDVV PLFLFSTRAV YIPPQVFNAV DAYGLTSKFK LHGGSIASDI
     PSCNLIIMPN ENQRLGTQSL VEMRQSVLQA MGRNDSTPSI PYIVTPDWVE KSIEENCQVP
     EEDFTPVYA
//