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Protein

L-lactate dehydrogenase

Gene

TDEL0F00140

Organism
Torulaspora delbrueckii (strain ATCC 10662 / CBS 1146 / NBRC 0425 / NCYC 2629 / NRRL Y-866) (Yeast) (Candida colliculosa)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.UniRule annotation

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase (TDEL0C07030), L-lactate dehydrogenase (TDEL0H04490), L-lactate dehydrogenase (TDEL0F00140)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei94SubstrateUniRule annotation1
Binding sitei126SubstrateUniRule annotation1
Binding sitei157SubstrateUniRule annotation1
Active sitei181Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandNADUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00554; UER00611

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenaseUniRule annotation (EC:1.1.1.27UniRule annotation)
Gene namesi
Name:TDEL0F00140Imported
ORF Names:TDEL_0F00140Imported
OrganismiTorulaspora delbrueckii (strain ATCC 10662 / CBS 1146 / NBRC 0425 / NCYC 2629 / NRRL Y-866) (Yeast) (Candida colliculosa)Imported
Taxonomic identifieri1076872 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeTorulaspora
Proteomesi
  • UP000005627 Componenti: Chromosome 6

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 35HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi4950.XP_003682036.1

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 148Ldh_1_NInterPro annotationAdd BLAST139
Domaini151 – 315Ldh_1_CInterPro annotationAdd BLAST165

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

InParanoidiG8ZW31
KOiK00016
OrthoDBiEOG092C3G32

Family and domain databases

Gene3Di3.90.110.101 hit
HAMAPiMF_00488 Lactate_dehydrog, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR011304 L-lactate_DH
IPR018177 L-lactate_DH_AS
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01771 L-LDH-NAD, 1 hit
PROSITEiView protein in PROSITE
PS00064 L_LDH, 1 hit

Sequencei

Sequence statusi: Complete.

G8ZW31-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTRKDLKPV KIAVVGVGSV GSTTAYTLLL SGMAADIILI DINKDKAVGE
60 70 80 90 100
FMDLNHASPL SSEIQVRVGT YEDCADCAIV IVTGGANQKP GQSRMDLVSK
110 120 130 140 150
NAKIMEDIIP QIAKNAPNTI LLLATNPVDV LTLIAYKLSG FPPQRVIGSG
160 170 180 190 200
TLLDSVRLRY NLGRYFDVSS GSVDAFIVGE HGDSEVAAWS LASIAGMRLA
210 220 230 240 250
DYCEQSGMKF DKAALHKIYE ETRDAASNII KRKGYTAYGI AEGLTYIVSA
260 270 280 290 300
ILKDEGALLT VSTVGEYYGI KDVALSVPAK VGRNGAHHVA KLLLQDEEIK
310
EIQKSAESIK AACKKVGYD
Length:319
Mass (Da):34,130
Last modified:February 22, 2012 - v1
Checksum:iEAB50D6AC1C9B402
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE616747 Genomic DNA Translation: CCE92825.1
RefSeqiXP_003682036.1, XM_003681988.1

Genome annotation databases

EnsemblFungiiCCE92825; CCE92825; TDEL_0F00140
GeneIDi11501150
KEGGitdl:TDEL_0F00140

Similar proteinsi

Entry informationi

Entry nameiG8ZW31_TORDC
AccessioniPrimary (citable) accession number: G8ZW31
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: April 25, 2018
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported