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Protein

L-lactate dehydrogenase

Gene

TDEL0F00140

Organism
Torulaspora delbrueckii (strain ATCC 10662 / CBS 1146 / NBRC 0425 / NCYC 2629 / NRRL Y-866) (Yeast) (Candida colliculosa)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.UniRule annotation

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase (TDEL0C07030), L-lactate dehydrogenase (TDEL0H04490), L-lactate dehydrogenase (TDEL0F00140)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei181Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandNADUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00554; UER00611.

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenaseUniRule annotation (EC:1.1.1.27UniRule annotation)
Gene namesi
Name:TDEL0F00140Imported
ORF Names:TDEL_0F00140Imported
OrganismiTorulaspora delbrueckii (strain ATCC 10662 / CBS 1146 / NBRC 0425 / NCYC 2629 / NRRL Y-866) (Yeast) (Candida colliculosa)Imported
Taxonomic identifieri1076872 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeTorulaspora
Proteomesi
  • UP000005627 Componenti: Chromosome 6

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 35HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi4950.XP_003682036.1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 148Ldh_1_NInterPro annotationAdd BLAST139
Domaini151 – 315Ldh_1_CInterPro annotationAdd BLAST165

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

InParanoidiG8ZW31.
KOiK00016.
OrthoDBiEOG092C3G32.

Family and domain databases

Gene3Di3.90.110.10. 1 hit.
HAMAPiMF_00488. Lactate_dehydrog. 1 hit.
InterProiView protein in InterPro
IPR001557. L-lactate/malate_DH.
IPR011304. L-lactate_DH.
IPR018177. L-lactate_DH_AS.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR036291. NAD(P)-bd_dom_sf.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01771. L-LDH-NAD. 1 hit.
PROSITEiView protein in PROSITE
PS00064. L_LDH. 1 hit.

Sequencei

Sequence statusi: Complete.

G8ZW31-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTRKDLKPV KIAVVGVGSV GSTTAYTLLL SGMAADIILI DINKDKAVGE
60 70 80 90 100
FMDLNHASPL SSEIQVRVGT YEDCADCAIV IVTGGANQKP GQSRMDLVSK
110 120 130 140 150
NAKIMEDIIP QIAKNAPNTI LLLATNPVDV LTLIAYKLSG FPPQRVIGSG
160 170 180 190 200
TLLDSVRLRY NLGRYFDVSS GSVDAFIVGE HGDSEVAAWS LASIAGMRLA
210 220 230 240 250
DYCEQSGMKF DKAALHKIYE ETRDAASNII KRKGYTAYGI AEGLTYIVSA
260 270 280 290 300
ILKDEGALLT VSTVGEYYGI KDVALSVPAK VGRNGAHHVA KLLLQDEEIK
310
EIQKSAESIK AACKKVGYD
Length:319
Mass (Da):34,130
Last modified:February 22, 2012 - v1
Checksum:iEAB50D6AC1C9B402
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE616747 Genomic DNA. Translation: CCE92825.1.
RefSeqiXP_003682036.1. XM_003681988.1.

Genome annotation databases

EnsemblFungiiCCE92825; CCE92825; TDEL_0F00140.
GeneIDi11501150.
KEGGitdl:TDEL_0F00140.

Similar proteinsi

Entry informationi

Entry nameiG8ZW31_TORDC
AccessioniPrimary (citable) accession number: G8ZW31
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: October 25, 2017
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported