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G8WMA0

- G8WMA0_KLEOK

UniProt

G8WMA0 - G8WMA0_KLEOK

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Protein

Isocitrate dehydrogenase [NADP]

Gene
KOX_17560
Organism
Klebsiella oxytoca (strain ATCC 8724 / DSM 4798 / JCM 20051 / NBRC 3318 / NRRL B-199 / KCTC 1686)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciKOXY1006551:GH6O-3576-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:KOX_17560Imported
OrganismiKlebsiella oxytoca (strain ATCC 8724 / DSM 4798 / JCM 20051 / NBRC 3318 / NRRL B-199 / KCTC 1686)Imported
Taxonomic identifieri1006551 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella
ProteomesiUP000007843: Chromosome

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G8WMA0-1 [UniParc]FASTAAdd to Basket

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MESKVVVPAE GQKITLQNGK LNVPNNPIIP FIEGDGIGVD VTPAMLKVVD    50
AAVEKAYKGE RKISWMEVYT GEKSTQVYGQ DVWLPAETLD LIREYRVAIK 100
GPLTTPVGGG IRSLNVALRQ ELDLYVCLRP VRYYQGTPSP VKHPELTDMV 150
IFRENSEDIY AGIEWKADSA EADKVIKFLR DEMGVKKIRF PEHCGIGIKP 200
CSEEGTKRLV RAAIEYAITN DRDSLTLVHK GNIMKFTEGA FKDWGYQLAR 250
EEFGGELIDG GPWLKIKNPN TGKEIVVKDV IADAFLQQIL LRPAEYDVIA 300
CMNLNGDYIS DALAAQVGGI GIAPGANIGD ECALFEATHG TAPKYAGQDK 350
VNPGSIILSA EMMLRHMQWF EAADLIVKGM EGAIAAKTVT YDFERLMEGA 400
KLLKCSEFGD AIIANM 416
Length:416
Mass (Da):45,759
Last modified:February 22, 2012 - v1
Checksum:iD958D399C403CAEC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003218 Genomic DNA. Translation: AEX05234.1.
RefSeqiYP_005019473.1. NC_016612.1.

Genome annotation databases

EnsemblBacteriaiAEX05234; AEX05234; KOX_17560.
GeneIDi11661270.
KEGGikox:KOX_17560.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003218 Genomic DNA. Translation: AEX05234.1 .
RefSeqi YP_005019473.1. NC_016612.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEX05234 ; AEX05234 ; KOX_17560 .
GeneIDi 11661270.
KEGGi kox:KOX_17560.

Phylogenomic databases

KOi K00031.

Enzyme and pathway databases

BioCyci KOXY1006551:GH6O-3576-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Klebsiella oxytoca strain KCTC 1686."
    Shin S.H., Kim S., Kim J.Y., Yang K.-S., Seo J.-S.
    Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 8724 / DSM 4798 / JCM 20051 / NBRC 3318 / NRRL B-199 / KCTC 1686.

Entry informationi

Entry nameiG8WMA0_KLEOK
AccessioniPrimary (citable) accession number: G8WMA0
Entry historyi
Integrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: October 16, 2013
This is version 12 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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