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Protein

Isocitrate dehydrogenase [NADP]

Gene

KOX_17560

Organism
Klebsiella oxytoca (strain ATCC 8724 / DSM 4798 / JCM 20051 / NBRC 3318 / NRRL B-199 / KCTC 1686)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciKOXY1006551:GH6O-3576-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:KOX_17560Imported
OrganismiKlebsiella oxytoca (strain ATCC 8724 / DSM 4798 / JCM 20051 / NBRC 3318 / NRRL B-199 / KCTC 1686)Imported
Taxonomic identifieri1006551 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella
ProteomesiUP000007843: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G8WMA0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESKVVVPAE GQKITLQNGK LNVPNNPIIP FIEGDGIGVD VTPAMLKVVD
60 70 80 90 100
AAVEKAYKGE RKISWMEVYT GEKSTQVYGQ DVWLPAETLD LIREYRVAIK
110 120 130 140 150
GPLTTPVGGG IRSLNVALRQ ELDLYVCLRP VRYYQGTPSP VKHPELTDMV
160 170 180 190 200
IFRENSEDIY AGIEWKADSA EADKVIKFLR DEMGVKKIRF PEHCGIGIKP
210 220 230 240 250
CSEEGTKRLV RAAIEYAITN DRDSLTLVHK GNIMKFTEGA FKDWGYQLAR
260 270 280 290 300
EEFGGELIDG GPWLKIKNPN TGKEIVVKDV IADAFLQQIL LRPAEYDVIA
310 320 330 340 350
CMNLNGDYIS DALAAQVGGI GIAPGANIGD ECALFEATHG TAPKYAGQDK
360 370 380 390 400
VNPGSIILSA EMMLRHMQWF EAADLIVKGM EGAIAAKTVT YDFERLMEGA
410
KLLKCSEFGD AIIANM
Length:416
Mass (Da):45,759
Last modified:February 22, 2012 - v1
Checksum:iD958D399C403CAEC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003218 Genomic DNA. Translation: AEX05234.1.
RefSeqiWP_014228876.1. NC_016612.1.
YP_005019473.1. NC_016612.1.

Genome annotation databases

EnsemblBacteriaiAEX05234; AEX05234; KOX_17560.
GeneIDi11661270.
KEGGikox:KOX_17560.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003218 Genomic DNA. Translation: AEX05234.1.
RefSeqiWP_014228876.1. NC_016612.1.
YP_005019473.1. NC_016612.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEX05234; AEX05234; KOX_17560.
GeneIDi11661270.
KEGGikox:KOX_17560.

Phylogenomic databases

KOiK00031.

Enzyme and pathway databases

BioCyciKOXY1006551:GH6O-3576-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of Klebsiella oxytoca strain KCTC 1686."
    Shin S.H., Kim S., Kim J.Y., Yang K.-S., Seo J.-S.
    Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 8724 / DSM 4798 / JCM 20051 / NBRC 3318 / NRRL B-199 / KCTC 1686Imported.

Entry informationi

Entry nameiG8WMA0_KLEOK
AccessioniPrimary (citable) accession number: G8WMA0
Entry historyi
Integrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: March 4, 2015
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.