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G8W6A4

- G8W6A4_KLEPH

UniProt

G8W6A4 - G8W6A4_KLEPH

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Protein

Alanine racemase

Gene

KPHS_02770

Organism
Klebsiella pneumoniae subsp. pneumoniae (strain HS11286)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

Note: Pyridoxal phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei34 – 341Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei129 – 1291SubstrateUniRule annotation
Active sitei255 – 2551Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei303 – 3031Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciKPNE1125630:GJUV-289-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:KPHS_02770Imported
OrganismiKlebsiella pneumoniae subsp. pneumoniae (strain HS11286)Imported
Taxonomic identifieri1125630 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella
ProteomesiUP000007841: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei34 – 341N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliG8W6A4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.
OMAiWRDMARR.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G8W6A4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQAATVVINR RALRHNLQRL RELAPASKLV AVVKANAYGH GLLETARTLT
60 70 80 90 100
DADAFGVARL EEALRLRAGG IAQPILLLEG FFAAEDLAVI AAQRLHTAVH
110 120 130 140 150
SPEQLAALEQ ADLPEPVTVW MKLDTGMHRL GVRPEEAEAF YQRLSQCKNV
160 170 180 190 200
RQPVNVVSHF ARADEPTCGA TERQLDIFTT FTEGKPGLRS IAASGGILLW
210 220 230 240 250
PQSHYDWVRP GIILYGVSPL DDRSTGKDFG CQPVMTLTSS LIAVREHKAG
260 270 280 290 300
EPVGYGGTWI SERDTRLGVV AMGYGDGYPR AAPSGTPVLV NGREVPIVGR
310 320 330 340 350
VAMDMICVDL GPQAQDKAGD AVVLWGEGLP VERIAEITKV SAYELITRLT

SRVAMKYLD
Length:359
Mass (Da):38,965
Last modified:February 22, 2012 - v1
Checksum:iC62E6E17B6D82363
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003200 Genomic DNA. Translation: AEW58975.1.
RefSeqiYP_005224577.1. NC_016845.1.

Genome annotation databases

EnsemblBacteriaiAEW58975; AEW58975; KPHS_02770.
GeneIDi11845264.
KEGGikpm:KPHS_02770.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003200 Genomic DNA. Translation: AEW58975.1 .
RefSeqi YP_005224577.1. NC_016845.1.

3D structure databases

ProteinModelPortali G8W6A4.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEW58975 ; AEW58975 ; KPHS_02770 .
GeneIDi 11845264.
KEGGi kpm:KPHS_02770.

Phylogenomic databases

KOi K01775.
OMAi WRDMARR.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci KPNE1125630:GJUV-289-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Klebsiella pneumoniae subsp. pneumoniae HS11286, a multidrug-resistant strain Isolated from human sputum."
    Liu P., Li P., Jiang X., Bi D., Xie Y., Tai C., Deng Z., Rajakumar K., Ou H.Y.
    J. Bacteriol. 194:1841-1842(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HS11286Imported.

Entry informationi

Entry nameiG8W6A4_KLEPH
AccessioniPrimary (citable) accession number: G8W6A4
Entry historyi
Integrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: November 26, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3