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G8W6A4 (G8W6A4_KLEPH) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length359 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity. HAMAP-Rule MF_01201

Catalytic activity

L-alanine = D-alanine. HAMAP-Rule MF_01201 SAAS SAAS020622

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01201 SAAS SAAS020622

Pathway

Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP-Rule MF_01201

Sequence similarities

Belongs to the alanine racemase family. RuleBase RU004188 HAMAP-Rule MF_01201

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site341Proton acceptor; specific for D-alanine By similarity HAMAP-Rule MF_01201
Active site2551Proton acceptor; specific for L-alanine By similarity HAMAP-Rule MF_01201
Binding site1291Substrate By similarity HAMAP-Rule MF_01201
Binding site3031Substrate; via amide nitrogen By similarity HAMAP-Rule MF_01201

Amino acid modifications

Modified residue341N6-(pyridoxal phosphate)lysine By similarity HAMAP-Rule MF_01201

Sequences

Sequence LengthMass (Da)Tools
G8W6A4 [UniParc].

Last modified February 22, 2012. Version 1.
Checksum: C62E6E17B6D82363

FASTA35938,965
        10         20         30         40         50         60 
MQAATVVINR RALRHNLQRL RELAPASKLV AVVKANAYGH GLLETARTLT DADAFGVARL 

        70         80         90        100        110        120 
EEALRLRAGG IAQPILLLEG FFAAEDLAVI AAQRLHTAVH SPEQLAALEQ ADLPEPVTVW 

       130        140        150        160        170        180 
MKLDTGMHRL GVRPEEAEAF YQRLSQCKNV RQPVNVVSHF ARADEPTCGA TERQLDIFTT 

       190        200        210        220        230        240 
FTEGKPGLRS IAASGGILLW PQSHYDWVRP GIILYGVSPL DDRSTGKDFG CQPVMTLTSS 

       250        260        270        280        290        300 
LIAVREHKAG EPVGYGGTWI SERDTRLGVV AMGYGDGYPR AAPSGTPVLV NGREVPIVGR 

       310        320        330        340        350 
VAMDMICVDL GPQAQDKAGD AVVLWGEGLP VERIAEITKV SAYELITRLT SRVAMKYLD 

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References

[1]"Complete Genome Sequence of Klebsiella pneumoniae subsp. pneumoniae HS11286, a Multidrug-Resistant Strain Isolated from Human Sputum."
Liu P., Li P., Jiang X., Bi D., Xie Y., Tai C., Deng Z., Rajakumar K., Ou H.Y.
J. Bacteriol. 194:1841-1842(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HS11286 EMBL AEW58975.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP003200 Genomic DNA. Translation: AEW58975.1.
RefSeqYP_005224577.1. NC_016845.1.

3D structure databases

ProteinModelPortalG8W6A4.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEW58975; AEW58975; KPHS_02770.
GeneID11845264.
KEGGkpm:KPHS_02770.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01775.
OMAWRDMARR.

Enzyme and pathway databases

BioCycKPNE1125630:GJUV-289-MONOMER.
UniPathwayUPA00042; UER00497.

Family and domain databases

Gene3D2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPMF_01201. Ala_racemase.
InterProIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSPR00992. ALARACEMASE.
SMARTSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsTIGR00492. alr. 1 hit.
PROSITEPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG8W6A4_KLEPH
AccessionPrimary (citable) accession number: G8W6A4
Entry history
Integrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: July 9, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)