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Protein
Submitted name:

Alpha-ketoglutarate decarboxylase

Gene

kgd

Organism
Propionibacterium acnes TypeIA2 P.acn31
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. 2-oxoglutarate decarboxylase activity Source: UniProtKB-EC
  2. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: InterPro
  3. thiamine pyrophosphate binding Source: InterPro
  4. transferase activity, transferring acyl groups Source: InterPro

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseImported

Enzyme and pathway databases

BioCyciPACN1114969:GJUU-1244-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Alpha-ketoglutarate decarboxylaseImported (EC:4.1.1.71Imported)
Gene namesi
Name:kgdImported
ORF Names:TIA2EST36_06245Imported
OrganismiPropionibacterium acnes TypeIA2 P.acn31Imported
Taxonomic identifieri1114969 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaePropionibacteriaceaePropionibacterium
ProteomesiUP000007852: Chromosome

Family & Domainsi

Phylogenomic databases

KOiK00164.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
3.40.50.970. 2 hits.
InterProiIPR001078. 2-oxoacid_DH_actylTfrase.
IPR011603. 2oxoglutarate_DH_E1.
IPR023213. CAT-like_dom.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00198. 2-oxoacid_dh. 1 hit.
PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

G8VNE2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSPAPHDKSN NSPDFGANDW LIEEMRDQYQ SDPNSVDPAW ATFFRKEAVE
60 70 80 90 100
STDSVTKSAA KDVPGASAPK PATKPQPVPA AKPAPITAPK PQKQPPRPPM
110 120 130 140 150
SADAPRHSAK LETVEPTVTK MKGAPMRTAK NMDQSLTMPT ATTVRDVPMQ
160 170 180 190 200
LVIEQRTMIN SFLKKAKGGK VSFTHILAYA MVQALKTVSA MNNAYAEIDG
210 220 230 240 250
KPHLIENHQI NLGMAIDVIA SDGSRKLVVP AIKGAEQMDF LDFWRAYEEI
260 270 280 290 300
VRKGRTNELT VDDFKGVTAS LTNPGGFGTN HSIARLMPGQ GMILGVGSID
310 320 330 340 350
YPAAYQGNSP TRIAELGISK VTTLTSTYDH RIIQGAQSGE FLRRMHQLLL
360 370 380 390 400
GADRFYEDIF ESLRIPYAPV QWASDRLANR ADQVGKQARV IELIDAWRRF
410 420 430 440 450
GHLSADLDPI EYRPRFHRDL MLNSHGLTLW DFDRTFPIAN FAGQRRATMS
460 470 480 490 500
LREILTILRD SYASKMGIEY MHIADYEQRK WFQDRFEKEH QPLSRKMHLQ
510 520 530 540 550
ILDQLNEAEI FETFLQTKFV GQKRFSLEGG ESAIVLLAAL CNRAADDGLN
560 570 580 590 600
EVCIGMPHRG RLNVLANIIG KSYGQIFREF EGNAEPVNSQ GSGDVKYHLG
610 620 630 640 650
DEGQFTAASG NTIKASVAAN PSHLEAVDPV LEGICRAKLD ALGNPEGFPV
660 670 680 690 700
LPILMHGDAA FAGQGVVYET LQMSQLGGYR TGGTIHVIVN NQVGFTTSPR
710 720 730 740 750
DGRSSTYCTD VAKAVGAPVL HVNGDDPASV VHAARIAYEY RQTFHRDVVV
760 770 780 790 800
DVVCYRRRGH NEGDDPSFTQ PHMYGLIAEK RSTRKLYTES LIGRGDITTE
810 820 830 840 850
DAEAVMTKFR SRLETVFKEV REATSTPEPY SGVPDYPVKH SGLHQTKVEP
860 870 880 890 900
DTMEAVARAH ENLPESFNAH PKVAPQMTRR AKHIREGGID WATGEMIALG
910 920 930 940 950
SLLRDGVHVR LAGQDSRRGT FSQRFAALVD HETGEFYVPV NHLGGEQAHL
960 970 980 990 1000
DVFDSPLNEY AAMGFEYGYS VARPDSLVLW EAQFGDFTNG AQTIIDEFIA
1010 1020 1030 1040 1050
SAGSKWGQKS GVVLLLPHGY EGQGPDHSSA RLERFLNLCS EDALAVCQPS
1060 1070 1080 1090 1100
TPASYSHLLR QHAYVNMHRP VVIATPKSML RNKMATSDPE DFTTGRWRPV
1110 1120 1130 1140 1150
LPDPSITDPT AVTRIILCSG KARWELVKQR KATSLDGQLA IIPMERLYPL
1160 1170 1180 1190 1200
PVDELAEVLA PYTNVTDVRW VQEEPENQGA WYYMLTHLPQ AMSEKLPGFF
1210 1220 1230
DGLVGITRPP SSAPSVGQHS VHIREEQELL EKAMA
Length:1,235
Mass (Da):136,717
Last modified:February 22, 2012 - v1
Checksum:iDA916B92886E8859
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003197 Genomic DNA. Translation: AEW83835.1.
RefSeqiWP_002517855.1. NC_016511.1.
YP_004944518.1. NC_016511.1.

Genome annotation databases

EnsemblBacteriaiAEW83835; AEW83835; TIA2EST36_06245.
GeneIDi11480493.
KEGGipax:TIA2EST36_06245.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003197 Genomic DNA. Translation: AEW83835.1.
RefSeqiWP_002517855.1. NC_016511.1.
YP_004944518.1. NC_016511.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEW83835; AEW83835; TIA2EST36_06245.
GeneIDi11480493.
KEGGipax:TIA2EST36_06245.

Phylogenomic databases

KOiK00164.

Enzyme and pathway databases

BioCyciPACN1114969:GJUU-1244-MONOMER.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
3.40.50.970. 2 hits.
InterProiIPR001078. 2-oxoacid_DH_actylTfrase.
IPR011603. 2oxoglutarate_DH_E1.
IPR023213. CAT-like_dom.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00198. 2-oxoacid_dh. 1 hit.
PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete Genome Sequences of Three Propionibacterium acnes Isolates from the Type IA2 Cluster."
    Voros A., Horvath B., Hunyadkurti J., McDowell A., Barnard E., Patrick S., Nagy I.
    J. Bacteriol. 194:1621-1622(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: P.acn31Imported.

Entry informationi

Entry nameiG8VNE2_PROAA
AccessioniPrimary (citable) accession number: G8VNE2
Entry historyi
Integrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: January 7, 2015
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.