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Protein
Submitted name:

Isocitrate dehydrogenase, NADP-dependent

Gene

TIA2EST36_08520

Organism
Propionibacterium acnes TypeIA2 P.acn31
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg(2+) or Mn2+ ion per subunit.UniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: InterPro
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciPACN1114969:GJUU-1700-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase, NADP-dependentImported
Gene namesi
ORF Names:TIA2EST36_08520Imported
OrganismiPropionibacterium acnes TypeIA2 P.acn31Imported
Taxonomic identifieri1114969 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaePropionibacteriaceaePropionibacterium
ProteomesiUP000007852: Chromosome

Family & Domainsi

Phylogenomic databases

KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

G8VM15-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPTIVWTKID EAPALASYSL LPIVEGFLDG SGIDITTSDI SLAGRILAQF
60 70 80 90 100
PDRLNEDQKV ADHLAELGEL TGSPDANIIK LPNISASVPQ LKAAIAELQS
110 120 130 140 150
QGYELPDFPD KPSTDEEREI AARYATVLGS AVNPVLRQGN SDRRAPTAVK
160 170 180 190 200
AYAKAHPHRM GQWTDQVKAR VAHMDHGDFF DHEESFVSRG QDLDVVLIGT
210 220 230 240 250
DGSETTLVSG IKTLDGEIVD ATFMSVDALD EFYASSLAQA NEEDLLWSVH
260 270 280 290 300
LKATMMKVSD PVLFGHAVRT FLVDVFDKYG DDLNSVGVNP DLGLGDLYTR
310 320 330 340 350
LEKLPAERAT AIKAAIDSAF AARPALAMVD SDNGITNLHA GNLVIIDASM
360 370 380 390 400
PTVVRDSGCM WNAEGKRQET LACIPDRSYA TMYAAIMDDC REHGALDPAT
410 420 430 440 450
MGDVPNVGLM AQKAEEYGSH PTTFIVPHDG RVEVRCGDEV LTNQQVEAGD
460 470 480 490 500
VWRMSRVRDI PVRDWVRLAI ERARITNTPA VFWLDKNRAH DARVIEKVKA
510 520 530 540 550
YLPEHEGLDI RILAPADAMK FTLARIRRGE DTISVTGNVL RDYLTDVFPI
560 570 580 590 600
LEIGTSAKML SVVPLLAGGG LFETGAGGSA PKHVAQFVAE DYLRWDSLGE
610 620 630 640 650
FCALGACLEH IDQTSEGTKA GILAATLDKA IGAFLENDRS PARKLGQSDN
660 670 680 690 700
RGSHYWLARY WASELAAQHD DAELADRFSD VATELAARED QILKELNGVQ
710 720 730
GSPVDMGGYY HPDEELVAEA MRPSTTFNAI IESL
Length:734
Mass (Da):79,967
Last modified:February 22, 2012 - v1
Checksum:i74AD29981DA085D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003197 Genomic DNA. Translation: AEW84274.1.
RefSeqiWP_002544331.1. NC_016511.1.
YP_004944957.1. NC_016511.1.

Genome annotation databases

EnsemblBacteriaiAEW84274; AEW84274; TIA2EST36_08520.
GeneIDi11481176.
KEGGipax:TIA2EST36_08520.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003197 Genomic DNA. Translation: AEW84274.1.
RefSeqiWP_002544331.1. NC_016511.1.
YP_004944957.1. NC_016511.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEW84274; AEW84274; TIA2EST36_08520.
GeneIDi11481176.
KEGGipax:TIA2EST36_08520.

Phylogenomic databases

KOiK00031.

Enzyme and pathway databases

BioCyciPACN1114969:GJUU-1700-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete Genome Sequences of Three Propionibacterium acnes Isolates from the Type IA2 Cluster."
    Voros A., Horvath B., Hunyadkurti J., McDowell A., Barnard E., Patrick S., Nagy I.
    J. Bacteriol. 194:1621-1622(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: P.acn31Imported.

Entry informationi

Entry nameiG8VM15_PROAA
AccessioniPrimary (citable) accession number: G8VM15
Entry historyi
Integrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: February 4, 2015
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.