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G8VM15

- G8VM15_PROAA

UniProt

G8VM15 - G8VM15_PROAA

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Protein
Submitted name:

Isocitrate dehydrogenase, NADP-dependent

Gene
TIA2EST36_08520
Organism
Propionibacterium acnes TypeIA2 P.acn31
Status
Unreviewed - Annotation score: 1 out of 5 - Protein predictedi

Functioni

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei143 – 1431Substrate By similarity
Sitei252 – 2521Critical for catalysis By similarityUniRule annotation
Metal bindingi347 – 3471Magnesium or manganese By similarityUniRule annotation
Sitei417 – 4171Critical for catalysis By similarityUniRule annotation
Binding sitei541 – 5411Substrate By similarityUniRule annotation
Metal bindingi542 – 5421Magnesium or manganese By similarityUniRule annotation
Metal bindingi546 – 5461Magnesium or manganese By similarityUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: InterPro
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciPACN1114969:GJUU-1700-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase, NADP-dependentImported
Gene namesi
ORF Names:TIA2EST36_08520Imported
OrganismiPropionibacterium acnes TypeIA2 P.acn31Imported
Taxonomic identifieri1114969 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaePropionibacteriaceaePropionibacterium
ProteomesiUP000007852: Chromosome

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni130 – 1378Substrate binding By similarity

Phylogenomic databases

KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

G8VM15-1 [UniParc]FASTAAdd to Basket

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MPTIVWTKID EAPALASYSL LPIVEGFLDG SGIDITTSDI SLAGRILAQF    50
PDRLNEDQKV ADHLAELGEL TGSPDANIIK LPNISASVPQ LKAAIAELQS 100
QGYELPDFPD KPSTDEEREI AARYATVLGS AVNPVLRQGN SDRRAPTAVK 150
AYAKAHPHRM GQWTDQVKAR VAHMDHGDFF DHEESFVSRG QDLDVVLIGT 200
DGSETTLVSG IKTLDGEIVD ATFMSVDALD EFYASSLAQA NEEDLLWSVH 250
LKATMMKVSD PVLFGHAVRT FLVDVFDKYG DDLNSVGVNP DLGLGDLYTR 300
LEKLPAERAT AIKAAIDSAF AARPALAMVD SDNGITNLHA GNLVIIDASM 350
PTVVRDSGCM WNAEGKRQET LACIPDRSYA TMYAAIMDDC REHGALDPAT 400
MGDVPNVGLM AQKAEEYGSH PTTFIVPHDG RVEVRCGDEV LTNQQVEAGD 450
VWRMSRVRDI PVRDWVRLAI ERARITNTPA VFWLDKNRAH DARVIEKVKA 500
YLPEHEGLDI RILAPADAMK FTLARIRRGE DTISVTGNVL RDYLTDVFPI 550
LEIGTSAKML SVVPLLAGGG LFETGAGGSA PKHVAQFVAE DYLRWDSLGE 600
FCALGACLEH IDQTSEGTKA GILAATLDKA IGAFLENDRS PARKLGQSDN 650
RGSHYWLARY WASELAAQHD DAELADRFSD VATELAARED QILKELNGVQ 700
GSPVDMGGYY HPDEELVAEA MRPSTTFNAI IESL 734
Length:734
Mass (Da):79,967
Last modified:February 22, 2012 - v1
Checksum:i74AD29981DA085D6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003197 Genomic DNA. Translation: AEW84274.1.
RefSeqiYP_004944957.1. NC_016511.1.

Genome annotation databases

EnsemblBacteriaiAEW84274; AEW84274; TIA2EST36_08520.
GeneIDi11481176.
KEGGipax:TIA2EST36_08520.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003197 Genomic DNA. Translation: AEW84274.1 .
RefSeqi YP_004944957.1. NC_016511.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEW84274 ; AEW84274 ; TIA2EST36_08520 .
GeneIDi 11481176.
KEGGi pax:TIA2EST36_08520.

Phylogenomic databases

KOi K00031.

Enzyme and pathway databases

BioCyci PACN1114969:GJUU-1700-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 3 hits.
InterProi IPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
Pfami PF03971. IDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete Genome Sequences of Three Propionibacterium acnes Isolates from the Type IA2 Cluster."
    Voros A., Horvath B., Hunyadkurti J., McDowell A., Barnard E., Patrick S., Nagy I.
    J. Bacteriol. 194:1621-1622(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: P.acn31Imported.

Entry informationi

Entry nameiG8VM15_PROAA
AccessioniPrimary (citable) accession number: G8VM15
Entry historyi
Integrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: September 3, 2014
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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