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G8VM15

- G8VM15_PROAA

UniProt

G8VM15 - G8VM15_PROAA

Protein
Submitted name:

Isocitrate dehydrogenase, NADP-dependent

Gene

TIA2EST36_08520

Organism
Propionibacterium acnes TypeIA2 P.acn31
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi
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    • History
      Entry version 16 (01 Oct 2014)
      Sequence version 1 (22 Feb 2012)
      Previous versions | rss
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    Functioni

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei143 – 1431SubstrateUniRule annotation
    Sitei252 – 2521Critical for catalysis
    Metal bindingi347 – 3471Magnesium or manganeseUniRule annotation
    Sitei417 – 4171Critical for catalysisUniRule annotation
    Binding sitei541 – 5411SubstrateUniRule annotation
    Metal bindingi542 – 5421Magnesium or manganeseUniRule annotation
    Metal bindingi546 – 5461Magnesium or manganeseUniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: InterPro
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. tricarboxylic acid cycle Source: InterPro

    Keywords - Ligandi

    MagnesiumUniRule annotation, Metal-bindingUniRule annotation

    Enzyme and pathway databases

    BioCyciPACN1114969:GJUU-1700-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Isocitrate dehydrogenase, NADP-dependentImported
    Gene namesi
    ORF Names:TIA2EST36_08520Imported
    OrganismiPropionibacterium acnes TypeIA2 P.acn31Imported
    Taxonomic identifieri1114969 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaePropionibacteriaceaePropionibacterium
    ProteomesiUP000007852: Chromosome

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni130 – 1378Substrate bindingUniRule annotation

    Phylogenomic databases

    KOiK00031.

    Family and domain databases

    Gene3Di3.40.718.10. 3 hits.
    InterProiIPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PfamiPF03971. IDH. 1 hit.
    [Graphical view]
    PIRSFiPIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    G8VM15-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPTIVWTKID EAPALASYSL LPIVEGFLDG SGIDITTSDI SLAGRILAQF    50
    PDRLNEDQKV ADHLAELGEL TGSPDANIIK LPNISASVPQ LKAAIAELQS 100
    QGYELPDFPD KPSTDEEREI AARYATVLGS AVNPVLRQGN SDRRAPTAVK 150
    AYAKAHPHRM GQWTDQVKAR VAHMDHGDFF DHEESFVSRG QDLDVVLIGT 200
    DGSETTLVSG IKTLDGEIVD ATFMSVDALD EFYASSLAQA NEEDLLWSVH 250
    LKATMMKVSD PVLFGHAVRT FLVDVFDKYG DDLNSVGVNP DLGLGDLYTR 300
    LEKLPAERAT AIKAAIDSAF AARPALAMVD SDNGITNLHA GNLVIIDASM 350
    PTVVRDSGCM WNAEGKRQET LACIPDRSYA TMYAAIMDDC REHGALDPAT 400
    MGDVPNVGLM AQKAEEYGSH PTTFIVPHDG RVEVRCGDEV LTNQQVEAGD 450
    VWRMSRVRDI PVRDWVRLAI ERARITNTPA VFWLDKNRAH DARVIEKVKA 500
    YLPEHEGLDI RILAPADAMK FTLARIRRGE DTISVTGNVL RDYLTDVFPI 550
    LEIGTSAKML SVVPLLAGGG LFETGAGGSA PKHVAQFVAE DYLRWDSLGE 600
    FCALGACLEH IDQTSEGTKA GILAATLDKA IGAFLENDRS PARKLGQSDN 650
    RGSHYWLARY WASELAAQHD DAELADRFSD VATELAARED QILKELNGVQ 700
    GSPVDMGGYY HPDEELVAEA MRPSTTFNAI IESL 734
    Length:734
    Mass (Da):79,967
    Last modified:February 22, 2012 - v1
    Checksum:i74AD29981DA085D6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003197 Genomic DNA. Translation: AEW84274.1.
    RefSeqiYP_004944957.1. NC_016511.1.

    Genome annotation databases

    EnsemblBacteriaiAEW84274; AEW84274; TIA2EST36_08520.
    GeneIDi11481176.
    KEGGipax:TIA2EST36_08520.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003197 Genomic DNA. Translation: AEW84274.1 .
    RefSeqi YP_004944957.1. NC_016511.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEW84274 ; AEW84274 ; TIA2EST36_08520 .
    GeneIDi 11481176.
    KEGGi pax:TIA2EST36_08520.

    Phylogenomic databases

    KOi K00031.

    Enzyme and pathway databases

    BioCyci PACN1114969:GJUU-1700-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 3 hits.
    InterProi IPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    Pfami PF03971. IDH. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete Genome Sequences of Three Propionibacterium acnes Isolates from the Type IA2 Cluster."
      Voros A., Horvath B., Hunyadkurti J., McDowell A., Barnard E., Patrick S., Nagy I.
      J. Bacteriol. 194:1621-1622(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: P.acn31Imported.

    Entry informationi

    Entry nameiG8VM15_PROAA
    AccessioniPrimary (citable) accession number: G8VM15
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 22, 2012
    Last sequence update: February 22, 2012
    Last modified: October 1, 2014
    This is version 16 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3