G8VM15 (G8VM15_PROAA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Isocitrate dehydrogenase, NADP-dependent EMBL AEW84274.1

Gene names

ORF Names:

TIA2EST36_08520 EMBL AEW84274.1

Organism

Propionibacterium acnes TypeIA2 P.acn31 EMBL AEW84274.1

Taxonomic identifier

1114969 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Propionibacterineae › Propionibacteriaceae › Propionibacterium › Propionibacterium acnes

Protein attributes

Sequence length	734 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRSR PIRSR009407-3

Ontologies

Keywords
Ligand	Magnesium PIRSR PIRSR009407-3 Metal-binding PIRSR PIRSR009407-3
Gene Ontology (GO)
Biological_process	tricarboxylic acid cycle Inferred from electronic annotation. Source: InterPro
Molecular_function	isocitrate dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Region	130 – 137	8	Substrate binding By similarity PIRSR PIRSR009407-2
Sites
	Metal binding	347	1	Magnesium or manganese By similarity PIRSR PIRSR009407-3
	Metal binding	542	1	Magnesium or manganese By similarity PIRSR PIRSR009407-3
	Metal binding	546	1	Magnesium or manganese By similarity PIRSR PIRSR009407-3
	Binding site	143	1	Substrate By similarity PIRSR PIRSR009407-2
	Binding site	541	1	Substrate By similarity PIRSR PIRSR009407-2
	Site	252	1	Critical for catalysis By similarity PIRSR PIRSR009407-1
	Site	417	1	Critical for catalysis By similarity PIRSR PIRSR009407-1

Sequences

	Sequence		Length	Mass (Da)
	G8VM15 [UniParc]. Last modified February 22, 2012. Version 1. Checksum: 74AD29981DA085D6	FASTA	734	79,967
	10 20 30 40 50 60 MPTIVWTKID EAPALASYSL LPIVEGFLDG SGIDITTSDI SLAGRILAQF PDRLNEDQKV 70 80 90 100 110 120 ADHLAELGEL TGSPDANIIK LPNISASVPQ LKAAIAELQS QGYELPDFPD KPSTDEEREI 130 140 150 160 170 180 AARYATVLGS AVNPVLRQGN SDRRAPTAVK AYAKAHPHRM GQWTDQVKAR VAHMDHGDFF 190 200 210 220 230 240 DHEESFVSRG QDLDVVLIGT DGSETTLVSG IKTLDGEIVD ATFMSVDALD EFYASSLAQA 250 260 270 280 290 300 NEEDLLWSVH LKATMMKVSD PVLFGHAVRT FLVDVFDKYG DDLNSVGVNP DLGLGDLYTR 310 320 330 340 350 360 LEKLPAERAT AIKAAIDSAF AARPALAMVD SDNGITNLHA GNLVIIDASM PTVVRDSGCM 370 380 390 400 410 420 WNAEGKRQET LACIPDRSYA TMYAAIMDDC REHGALDPAT MGDVPNVGLM AQKAEEYGSH 430 440 450 460 470 480 PTTFIVPHDG RVEVRCGDEV LTNQQVEAGD VWRMSRVRDI PVRDWVRLAI ERARITNTPA 490 500 510 520 530 540 VFWLDKNRAH DARVIEKVKA YLPEHEGLDI RILAPADAMK FTLARIRRGE DTISVTGNVL 550 560 570 580 590 600 RDYLTDVFPI LEIGTSAKML SVVPLLAGGG LFETGAGGSA PKHVAQFVAE DYLRWDSLGE 610 620 630 640 650 660 FCALGACLEH IDQTSEGTKA GILAATLDKA IGAFLENDRS PARKLGQSDN RGSHYWLARY 670 680 690 700 710 720 WASELAAQHD DAELADRFSD VATELAARED QILKELNGVQ GSPVDMGGYY HPDEELVAEA 730 MRPSTTFNAI IESL

References

[1]

"Complete Genome Sequences of Three Propionibacterium acnes Isolates from the Type IA2 Cluster." Voros A., Horvath B., Hunyadkurti J., McDowell A., Barnard E., Patrick S., Nagy I. J. Bacteriol. 194:1621-1622(2012) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: P.acn31 EMBL AEW84274.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP003197 Genomic DNA. Translation: AEW84274.1.
RefSeq	YP_004944957.1. NC_016511.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AEW84274; AEW84274; TIA2EST36_08520.
GeneID	11481176.
KEGG	pax:TIA2EST36_08520.
Phylogenomic databases
KO	K00031.
Family and domain databases
Gene3D	3.40.718.10. 3 hits.
InterPro	IPR004436. Isocitrate_DH_NADP_mono. IPR024084. IsoPropMal-DH-like_dom. [Graphical view]
Pfam	PF03971. IDH. 1 hit. [Graphical view]
PIRSF	PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMs	TIGR00178. monomer_idh. 1 hit.
ProtoNet	Search...

Entry information

Entry name

G8VM15_PROAA

Accession

Primary (citable) accession number: G8VM15

Entry history

Integrated into UniProtKB/TrEMBL:	February 22, 2012
Last sequence update:	February 22, 2012
Last modified:	April 3, 2013
This is version 10 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)