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G8VL29

- G8VL29_PROAA

UniProt

G8VL29 - G8VL29_PROAA

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Protein

Thymidine kinase

Gene

tdk

Organism
Propionibacterium acnes TypeIA2 P.acn31
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei87 – 871Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 168ATPUniRule annotation
Nucleotide bindingi86 – 894ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotation, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciPACN1114969:GJUU-1029-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
ORF Names:TIA2EST36_05190Imported
OrganismiPropionibacterium acnes TypeIA2 P.acn31Imported
Taxonomic identifieri1114969 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaePropionibacteriaceaePropionibacterium
ProteomesiUP000007852: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliG8VL29.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

KOiK00857.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

G8VL29-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAELVFHTGP MDSGKSTLAL QMDHAQSAHD RQGVRYAMHD RSGGARITSR
60 70 80 90 100
IGLSVEAVEV TDSLDLYQDI VSRLSRGGRI DYLICDEAQF YRTKQIDQLA
110 120 130 140 150
RVVDDLDIDV YCFGILADFR TELFPGSKRL VELADRVVEP PVSPLCWCGR
160 170 180 190 200
PATHNARIVD GKLVREGDQV GVGDIGGGSE IHYEVLCRRH HRQGITGEIS
210
RATLSEQTLP FDGSRS
Length:216
Mass (Da):23,926
Last modified:February 22, 2012 - v1
Checksum:iF6055E1F110118C5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003197 Genomic DNA. Translation: AEW83626.1.
RefSeqiYP_004944309.1. NC_016511.1.

Genome annotation databases

EnsemblBacteriaiAEW83626; AEW83626; TIA2EST36_05190.
GeneIDi11480278.
KEGGipax:TIA2EST36_05190.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003197 Genomic DNA. Translation: AEW83626.1 .
RefSeqi YP_004944309.1. NC_016511.1.

3D structure databases

ProteinModelPortali G8VL29.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEW83626 ; AEW83626 ; TIA2EST36_05190 .
GeneIDi 11480278.
KEGGi pax:TIA2EST36_05190.

Phylogenomic databases

KOi K00857.

Enzyme and pathway databases

BioCyci PACN1114969:GJUU-1029-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete Genome Sequences of Three Propionibacterium acnes Isolates from the Type IA2 Cluster."
    Voros A., Horvath B., Hunyadkurti J., McDowell A., Barnard E., Patrick S., Nagy I.
    J. Bacteriol. 194:1621-1622(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: P.acn31Imported.

Entry informationi

Entry nameiG8VL29_PROAA
AccessioniPrimary (citable) accession number: G8VL29
Entry historyi
Integrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: October 29, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3