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G8VH53 (G8VH53_PROAA) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 17. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
ORF Names:TIA2EST22_11575 EMBL AEW82599.1
OrganismPropionibacterium acnes TypeIA2 P.acn17 [Complete proteome] EMBL AEW82599.1
Taxonomic identifier1114967 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaePropionibacteriaceaePropionibacterium

Protein attributes

Sequence length315 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS011095

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. HAMAP-Rule MF_00047

Binds 2 magnesium or manganese ions per subunit By similarity. SAAS SAAS011095

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS011095

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS011095.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011095

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain101 – 308208ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding135 – 19056ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2621Magnesium or manganese By similarity HAMAP-Rule MF_00047
Metal binding2751Magnesium or manganese By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
G8VH53 [UniParc].

Last modified February 22, 2012. Version 1.
Checksum: B500E10AB6F66B25

FASTA31532,794
        10         20         30         40         50         60 
MLQPVVVLAG GLSHQRDISL KSGRTVAQAL RRVGHEVVEA DIDSALIETL RANDGAVVFP 

        70         80         90        100        110        120 
MLHGGLGENG ALLEVLQLMG IPYVGSSPAT CRISFDKSIA SRAVTAAGIV TPQQVALPHD 

       130        140        150        160        170        180 
VFRELGAQTV MRSIAEKFGL PVIVKPARGG SSLGVTKVDG VDDLPQAVAN AYAYDDMVVV 

       190        200        210        220        230        240 
EEFIVGTELA IGMITTSEGT RVLPAVEIRP VGGVYDYSAM YTGGETRLTA PADISDTAAQ 

       250        260        270        280        290        300 
TATAMARVVQ KELDFSGISR VDAIVDESGR PVFLEAGAAP GMTATSLVPV AMKAAGLDLG 

       310 
EVCSRLVDDV ARNHG 

« Hide

References

[1]"Complete Genome Sequences of Three Propionibacterium acnes Isolates from the Type IA2 Cluster."
Voros A., Horvath B., Hunyadkurti J., McDowell A., Barnard E., Patrick S., Nagy I.
J. Bacteriol. 194:1621-1622(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: P.acn17 EMBL AEW82599.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP003196 Genomic DNA. Translation: AEW82599.1.
RefSeqYP_004947789.1. NC_016512.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEW82599; AEW82599; TIA2EST22_11575.
GeneID11481844.
KEGGpav:TIA2EST22_11575.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.

Enzyme and pathway databases

BioCycPACN1114967:GJTL-2303-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG8VH53_PROAA
AccessionPrimary (citable) accession number: G8VH53
Entry history
Integrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: June 11, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)