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Protein

2,3-bisphosphoglycerate-dependent phosphoglycerate mutase

Gene

gpmA

Organism
Propionibacterium acnes TypeIA2 P.acn17
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.UniRule annotation

Catalytic activityi

2-phospho-D-glycerate = 3-phospho-D-glycerate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei10 – 101Tele-phosphohistidine intermediateUniRule annotation
Binding sitei16 – 1612-phospho-D-glycerateUniRule annotation
Binding sitei61 – 6112-phospho-D-glycerateUniRule annotation
Binding sitei99 – 9912-phospho-D-glycerateUniRule annotation
Active sitei183 – 1831UniRule annotation
Binding sitei185 – 18512-phospho-D-glycerateUniRule annotation

GO - Molecular functioni

  1. 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Biological processi

GlycolysisUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciPACN1114967:GJTL-352-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
2,3-bisphosphoglycerate-dependent phosphoglycerate mutaseUniRule annotation (EC:5.4.2.11UniRule annotation)
Short name:
BPG-dependent PGAMUniRule annotation
Short name:
PGAMUniRule annotation
Short name:
PhosphoglyceromutaseUniRule annotation
Short name:
dPGMUniRule annotation
Gene namesi
Name:gpmAUniRule annotation
ORF Names:TIA2EST22_01830Imported
OrganismiPropionibacterium acnes TypeIA2 P.acn17Imported
Taxonomic identifieri1114967 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaePropionibacteriaceaePropionibacterium
ProteomesiUP000007853: Chromosome

Structurei

3D structure databases

ProteinModelPortaliG8VGF4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni22 – 2322-phospho-D-glycerate bindingUniRule annotation
Regioni88 – 9142-phospho-D-glycerate bindingUniRule annotation
Regioni115 – 11622-phospho-D-glycerate bindingUniRule annotation

Sequence similaritiesi

Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.UniRule annotation

Phylogenomic databases

KOiK01834.

Family and domain databases

Gene3Di3.40.50.1240. 1 hit.
HAMAPiMF_01039. PGAM_GpmA.
InterProiIPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
IPR001345. PG/BPGM_mutase_AS.
IPR005952. Phosphogly_mut1.
[Graphical view]
PANTHERiPTHR11931. PTHR11931. 1 hit.
PfamiPF00300. His_Phos_1. 1 hit.
[Graphical view]
SMARTiSM00855. PGAM. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.
TIGRFAMsiTIGR01258. pgm_1. 1 hit.
PROSITEiPS00175. PG_MUTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G8VGF4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTAKLILLRH GESEWNSKNL FTGWVDVDLN EKGEGEARHA ADLLKQENLL
60 70 80 90 100
PDIVHTSLLR RAIHTAYLAL DGCDRHWIPV HRSWRLNERH YGALQGLNKA
110 120 130 140 150
ETKEKYGNDQ FMAWRRSYDV RPPDLDRDSE FSQFHDPRYA DIPASERPVA
160 170 180 190 200
ECLKDVVARM VPYFTSDIAA DLKDGKTVLV AAHGNSLRAL VKHLDEISDE
210 220 230 240
DIAGLNIPTG IPLFYELDDN LKPVTRGGRY LDPEAAAAGA KAVANQGNK
Length:249
Mass (Da):27,990
Last modified:February 22, 2012 - v1
Checksum:iE36BB2762B1D283D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003196 Genomic DNA. Translation: AEW80698.1.
RefSeqiYP_004945888.1. NC_016512.1.

Genome annotation databases

EnsemblBacteriaiAEW80698; AEW80698; TIA2EST22_01830.
GeneIDi11482743.
KEGGipav:TIA2EST22_01830.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003196 Genomic DNA. Translation: AEW80698.1.
RefSeqiYP_004945888.1. NC_016512.1.

3D structure databases

ProteinModelPortaliG8VGF4.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEW80698; AEW80698; TIA2EST22_01830.
GeneIDi11482743.
KEGGipav:TIA2EST22_01830.

Phylogenomic databases

KOiK01834.

Enzyme and pathway databases

BioCyciPACN1114967:GJTL-352-MONOMER.

Family and domain databases

Gene3Di3.40.50.1240. 1 hit.
HAMAPiMF_01039. PGAM_GpmA.
InterProiIPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
IPR001345. PG/BPGM_mutase_AS.
IPR005952. Phosphogly_mut1.
[Graphical view]
PANTHERiPTHR11931. PTHR11931. 1 hit.
PfamiPF00300. His_Phos_1. 1 hit.
[Graphical view]
SMARTiSM00855. PGAM. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.
TIGRFAMsiTIGR01258. pgm_1. 1 hit.
PROSITEiPS00175. PG_MUTASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete Genome Sequences of Three Propionibacterium acnes Isolates from the Type IA2 Cluster."
    Voros A., Horvath B., Hunyadkurti J., McDowell A., Barnard E., Patrick S., Nagy I.
    J. Bacteriol. 194:1621-1622(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: P.acn17Imported.

Entry informationi

Entry nameiG8VGF4_PROAA
AccessioniPrimary (citable) accession number: G8VGF4
Entry historyi
Integrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: February 4, 2015
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.