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G8V8X6 (G8V8X6_PROAA) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 14. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
6-phosphofructokinase HAMAP-Rule MF_00339

Short name=Phosphofructokinase HAMAP-Rule MF_00339
EC=2.7.1.11 HAMAP-Rule MF_00339
Alternative name(s):
Phosphohexokinase HAMAP-Rule MF_00339
Gene names
Name:pfkA HAMAP-Rule MF_00339
ORF Names:TIA2EST2_00440 EMBL AEW78201.1
OrganismPropionibacterium acnes TypeIA2 P.acn33 [Complete proteome] EMBL AEW78201.1
Taxonomic identifier1114966 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaePropionibacteriaceaePropionibacterium

Protein attributes

Sequence length410 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate. HAMAP-Rule MF_00339

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4. HAMAP-Rule MF_00339

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00339.

Sequence similarities

Belongs to the phosphofructokinase family. HAMAP-Rule MF_00339

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding59 – 635ATP By similarity HAMAP-Rule MF_00339
Nucleotide binding199 – 2035ATP By similarity HAMAP-Rule MF_00339
Nucleotide binding216 – 23217ATP By similarity HAMAP-Rule MF_00339

Sites

Active site1721Proton acceptor By similarity HAMAP-Rule MF_00339
Metal binding2301Magnesium; via carbonyl oxygen By similarity HAMAP-Rule MF_00339
Metal binding2321Magnesium By similarity HAMAP-Rule MF_00339
Binding site2071Substrate By similarity HAMAP-Rule MF_00339
Binding site3281Substrate By similarity HAMAP-Rule MF_00339
Binding site3341Substrate By similarity HAMAP-Rule MF_00339
Binding site3371Substrate By similarity HAMAP-Rule MF_00339

Sequences

Sequence LengthMass (Da)Tools
G8V8X6 [UniParc].

Last modified February 22, 2012. Version 1.
Checksum: 681893934F6CFBC8

FASTA41042,885
        10         20         30         40         50         60 
MAVVTVTHMI ATVDRSVVGA IHGRMGTTRH RSGVVMSKKK KVGILTAGGD CPGLNAAIRG 

        70         80         90        100        110        120 
FGKAAIRQHD MELIGIQDGF LGLAGNRTIS LDPRALSGIL TVGGTILGTS RDKVNHMIID 

       130        140        150        160        170        180 
GEERDMVPTI VENYEKLGLD ALVTLGGGGT AKNAYKLAKA GLNVLHLPKT IDNDIVGTDD 

       190        200        210        220        230        240 
SFGFSTALEI ATEAIDRLHS TAHSHHRIIL AEIMGHRAGW LALGSGIAGG ADVILLPEVP 

       250        260        270        280        290        300 
YKLDSIVQAV ENRQKQGLNF SVIAVAEGAR DEADSAAMAG AQALVDASKT SETKAAAKKA 

       310        320        330        340        350        360 
KKDLEHSMRD NTLKLATQLE EATGLESRVS ILGYVQRGGI PCAHDRLLAT RLGTVGAKLV 

       370        380        390        400        410 
DDGEFGIMVA AQGGDATTVP LKDVAGKVKY VPADHPWVKA ARQVGTGLGD 

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References

[1]"Complete Genome Sequences of Three Propionibacterium acnes Isolates from the Type IA2 Cluster."
Voros A., Horvath B., Hunyadkurti J., McDowell A., Barnard E., Patrick S., Nagy I.
J. Bacteriol. 194:1621-1622(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: P.acn33 EMBL AEW78201.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP003195 Genomic DNA. Translation: AEW78201.1.
RefSeqYP_004954564.1. NC_016516.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEW78201; AEW78201; TIA2EST2_00440.
GeneID11491808.
KEGGpaz:TIA2EST2_00440.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK00850.

Enzyme and pathway databases

BioCycPACN1114966:GJX4-85-MONOMER.
UniPathwayUPA00109; UER00182.

Family and domain databases

HAMAPMF_00339. Phosphofructokinase.
InterProIPR022953. Phosphofructokinase.
IPR000023. Phosphofructokinase_dom.
[Graphical view]
PfamPF00365. PFK. 2 hits.
[Graphical view]
PRINTSPR00476. PHFRCTKINASE.
SUPFAMSSF53784. SSF53784. 1 hit.
ProtoNetSearch...

Entry information

Entry nameG8V8X6_PROAA
AccessionPrimary (citable) accession number: G8V8X6
Entry history
Integrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: April 16, 2014
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)