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G8V3M3 (G8V3M3_STAAU) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 17. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
2-oxoglutarate dehydrogenase E1 component HAMAP-Rule MF_01169

EC=1.2.4.2 HAMAP-Rule MF_01169
Alternative name(s):
Alpha-ketoglutarate dehydrogenase HAMAP-Rule MF_01169
Gene names
Name:sucA EMBL AEW65378.1
Synonyms:odhA HAMAP-Rule MF_01169
ORF Names:MS7_1369 EMBL AEW65378.1
OrganismStaphylococcus aureus subsp. aureus 11819-97 [Complete proteome] EMBL AEW65378.1
Taxonomic identifier1123523 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length932 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity. HAMAP-Rule MF_01169 SAAS SAAS023784

Catalytic activity

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2. HAMAP-Rule MF_01169 SAAS SAAS023784

Cofactor

Thiamine pyrophosphate By similarity. HAMAP-Rule MF_01169 SAAS SAAS023784

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01169 SAAS SAAS023784

Sequence similarities

Belongs to the alpha-ketoglutarate dehydrogenase family. HAMAP-Rule MF_01169

Sequences

Sequence LengthMass (Da)Tools
G8V3M3 [UniParc].

Last modified February 22, 2012. Version 1.
Checksum: F671CE1A65ADAF6D

FASTA932105,357
        10         20         30         40         50         60 
MTNERKEVSE APVNFGANLG LMLDLYDDFL QDPSSVPEDL QVLFSTIKND DSIVPALKST 

        70         80         90        100        110        120 
SSQNSDGTIK RVMRLIDNIR QYGHLKADIY PVNPPKRKHV PKLEIEDFDL DQQTLEGISA 

       130        140        150        160        170        180 
GIVSDHFADI YDNAYEAILR MEKRYKGPIA FEYTHINNNT ERGWLKRRIE TPYKVTLNNN 

       190        200        210        220        230        240 
EKRALFKQLA YVEGFEKYLH KNFVGAKRFS IEGVDALVPM LQRTITIAAK EGIKNIQIGM 

       250        260        270        280        290        300 
AHRGRLNVLT HVLEKPYEMM ISEFMHTDPM KFLPEDGSLQ LTAGWTGDVK YHLGGIKTTD 

       310        320        330        340        350        360 
SYGTMQRIAL ANNPSHLEIV APVVEGRTRA AQDDTQRAGA PTTDHHKAMP IIIHGDAAYP 

       370        380        390        400        410        420 
GQGINFETMN LGNLKGYSTG GSLHIITNNR IGFTTEPIDA RSTTYSTDVA KGYDVPIFHV 

       430        440        450        460        470        480 
NADDVEATIE AIDIAMEFRK EFHKDVVIDL VGYRRFGHNE MDEPSITNPV PYQNIRKHDS 

       490        500        510        520        530        540 
VEYVFGKKLV NEGVISEDEM HSFIEQVQKE LRQAHDKINK ADKMDNPDME KPAELALPLQ 

       550        560        570        580        590        600 
ADEQSFTFDH LKEINDALLT YPDGFNILKK LNKVLEKRHE PFNKEDGLVD WAQAEQLAFA 

       610        620        630        640        650        660 
TILQDGTPIR LTGQDSERGT FSHRHAVLHD EQTGETYTPL HHVPDQKATF DIHNSPLSEA 

       670        680        690        700        710        720 
AVVGFEYGYN VENKKSFNIW EAQYGDFANM SQMIFDNFLF SSRSKWGERS GLTLFLPHAY 

       730        740        750        760        770        780 
EGQGPEHSSA RLERFLQLAA ENNCTVVNLS SSSNYFHLLR AQAASLDSEQ MRPLVVMSPK 

       790        800        810        820        830        840 
SLLRNKTVAK PIDEFTSGGF EPILTESYQA DKVTKVILAT GKMFIDLKEA LAKNPDESVL 

       850        860        870        880        890        900 
LVAIERLYPF PEEEIEALLA QLPNLEEVSW VQEEPKNQGA WLYVYPYVKV LVADKYDLSY 

       910        920        930 
HGRIQRAAPA EGDGEIHKLV QNKIIENALK NN 

« Hide

References

[1]"Genome Sequence of Staphylococcus aureus Strain 11819-97, an ST80-IV European Community-Acquired Methicillin-Resistant Isolate."
Stegger M., Price L.B., Larsen A.R., Gillece J.D., Waters A.E., Skov R., Andersen P.S.
J. Bacteriol. 194:1625-1626(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: 11819-97 EMBL AEW65378.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP003194 Genomic DNA. Translation: AEW65378.1.
RefSeqYP_005757810.1. NC_017351.1.

3D structure databases

ProteinModelPortalG8V3M3.
SMRG8V3M3. Positions 71-929.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEG8V3M3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEW65378; AEW65378; MS7_1369.
GeneID12424157.
KEGGsuz:MS7_1369.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK00164.

Enzyme and pathway databases

BioCycSAUR1123523:GLKH-1366-MONOMER.

Family and domain databases

Gene3D3.40.50.970. 2 hits.
HAMAPMF_01169. SucA_OdhA.
InterProIPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERPTHR23152. PTHR23152. 1 hit.
PfamPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMSSF52518. SSF52518. 2 hits.
TIGRFAMsTIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetSearch...

Entry information

Entry nameG8V3M3_STAAU
AccessionPrimary (citable) accession number: G8V3M3
Entry history
Integrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: June 11, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)