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Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Legionella pneumophila subsp. pneumophila ATCC 43290
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Note: Binds 1 magnesium or manganese ion per subunit.
  • Mg2+UniRule annotation, Mn2+UniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciLPNE933093:GH6R-822-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:icdImported
ORF Names:lp12_0833Imported
OrganismiLegionella pneumophila subsp. pneumophila ATCC 43290Imported
Taxonomic identifieri933093 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella
ProteomesiUP000007851 Componenti: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G8UXN8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESSMTYDKI KVPAQGEAIT VAADHSLHVP DNPIIPFIEG DGIGVDVTPP
60 70 80 90 100
MIRVVDAAVQ KAYGNKRKIS WMEVYAGEKA TKVYGSDQWL PKETLDAMKK
110 120 130 140 150
YVVSIKGPLT TPVGGGIRSL NVAIRQDMDL YVCLRPIRYF NGVPSPVREP
160 170 180 190 200
WKTDMVIFRE NSEDIYAGIE WQADTPEAKK VIQFLTKEMG VKKIRFPEHC
210 220 230 240 250
GIGVKPVSRE GTTRLVKAAI QYAIDNDRST VTLVHKGNIM KFTEGAFKDW
260 270 280 290 300
GYQVARDSFG AKEYQGGPWM EFKNPKTGKQ IIINDVIADA FLQQILLRPE
310 320 330 340 350
DYSVIATLNL NGDYISDALA AQVGGIGIAP GANISDQMAV FEATHGTAPK
360 370 380 390 400
YAGQNKVNPG SIILSAEMML RHMGWYEAAD LIIRGMEGAI EAKTVTYDFE
410 420
RGMQGATLVS SSGFADAMIK HM
Length:422
Mass (Da):46,447
Last modified:February 22, 2012 - v1
Checksum:i47B477E11B2796CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003192 Genomic DNA. Translation: AEW51103.1.
RefSeqiYP_005185202.1. NC_016811.1.

Genome annotation databases

EnsemblBacteriaiAEW51103; AEW51103; lp12_0833.
KEGGilpe:lp12_0833.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003192 Genomic DNA. Translation: AEW51103.1.
RefSeqiYP_005185202.1. NC_016811.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEW51103; AEW51103; lp12_0833.
KEGGilpe:lp12_0833.

Phylogenomic databases

KOiK00031.

Enzyme and pathway databases

BioCyciLPNE933093:GH6R-822-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Whole-Genome Sequence of the Human Pathogen Legionella pneumophila Serogroup 12 Strain 570-CO-H."
    Amaro F., Gilbert J.A., Owens S., Trimble W., Shuman H.A.
    J. Bacteriol. 194:1613-1614(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43290Imported.

Entry informationi

Entry nameiG8UXN8_LEGPN
AccessioniPrimary (citable) accession number: G8UXN8
Entry historyi
Integrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: April 29, 2015
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.