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G8UXN8

- G8UXN8_LEGPN

UniProt

G8UXN8 - G8UXN8_LEGPN

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Protein

Isocitrate dehydrogenase [NADP]

Gene
icd, lp12_0833
Organism
Legionella pneumophila subsp. pneumophila ATCC 43290
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciLPNE933093:GH6R-822-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:icdImported
ORF Names:lp12_0833Imported
OrganismiLegionella pneumophila subsp. pneumophila ATCC 43290Imported
Taxonomic identifieri933093 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella
ProteomesiUP000007851: Chromosome

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G8UXN8-1 [UniParc]FASTAAdd to Basket

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MESSMTYDKI KVPAQGEAIT VAADHSLHVP DNPIIPFIEG DGIGVDVTPP    50
MIRVVDAAVQ KAYGNKRKIS WMEVYAGEKA TKVYGSDQWL PKETLDAMKK 100
YVVSIKGPLT TPVGGGIRSL NVAIRQDMDL YVCLRPIRYF NGVPSPVREP 150
WKTDMVIFRE NSEDIYAGIE WQADTPEAKK VIQFLTKEMG VKKIRFPEHC 200
GIGVKPVSRE GTTRLVKAAI QYAIDNDRST VTLVHKGNIM KFTEGAFKDW 250
GYQVARDSFG AKEYQGGPWM EFKNPKTGKQ IIINDVIADA FLQQILLRPE 300
DYSVIATLNL NGDYISDALA AQVGGIGIAP GANISDQMAV FEATHGTAPK 350
YAGQNKVNPG SIILSAEMML RHMGWYEAAD LIIRGMEGAI EAKTVTYDFE 400
RGMQGATLVS SSGFADAMIK HM 422
Length:422
Mass (Da):46,447
Last modified:February 22, 2012 - v1
Checksum:i47B477E11B2796CF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003192 Genomic DNA. Translation: AEW51103.1.
RefSeqiYP_005185202.1. NC_016811.1.

Genome annotation databases

EnsemblBacteriaiAEW51103; AEW51103; lp12_0833.
GeneIDi11802011.
KEGGilpe:lp12_0833.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003192 Genomic DNA. Translation: AEW51103.1 .
RefSeqi YP_005185202.1. NC_016811.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEW51103 ; AEW51103 ; lp12_0833 .
GeneIDi 11802011.
KEGGi lpe:lp12_0833.

Phylogenomic databases

KOi K00031.

Enzyme and pathway databases

BioCyci LPNE933093:GH6R-822-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Whole-Genome Sequence of the Human Pathogen Legionella pneumophila Serogroup 12 Strain 570-CO-H."
    Amaro F., Gilbert J.A., Owens S., Trimble W., Shuman H.A.
    J. Bacteriol. 194:1613-1614(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43290Imported.

Entry informationi

Entry nameiG8UXN8_LEGPN
AccessioniPrimary (citable) accession number: G8UXN8
Entry historyi
Integrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: September 3, 2014
This is version 13 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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