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G8UXN8 (G8UXN8_LEGPN) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 9. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NADP] RuleBase RU004446
EC=1.1.1.42 RuleBase RU004446
Gene names
Name:icd EMBL AEW51103.1
ORF Names:lp12_0833 EMBL AEW51103.1
OrganismLegionella pneumophila subsp. pneumophila ATCC 43290 EMBL AEW51103.1
Taxonomic identifier933093 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Legionellaceae › Legionella ›

Protein attributes

Sequence length422 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. RuleBase RU004446

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. RuleBase RU004446

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. RuleBase RU004443

Sequences

Sequence LengthMass (Da)Tools
G8UXN8 [UniParc].

Last modified February 22, 2012. Version 1.
Checksum: 47B477E11B2796CF

FASTA42246,447
        10         20         30         40         50         60 
MESSMTYDKI KVPAQGEAIT VAADHSLHVP DNPIIPFIEG DGIGVDVTPP MIRVVDAAVQ 

        70         80         90        100        110        120 
KAYGNKRKIS WMEVYAGEKA TKVYGSDQWL PKETLDAMKK YVVSIKGPLT TPVGGGIRSL 

       130        140        150        160        170        180 
NVAIRQDMDL YVCLRPIRYF NGVPSPVREP WKTDMVIFRE NSEDIYAGIE WQADTPEAKK 

       190        200        210        220        230        240 
VIQFLTKEMG VKKIRFPEHC GIGVKPVSRE GTTRLVKAAI QYAIDNDRST VTLVHKGNIM 

       250        260        270        280        290        300 
KFTEGAFKDW GYQVARDSFG AKEYQGGPWM EFKNPKTGKQ IIINDVIADA FLQQILLRPE 

       310        320        330        340        350        360 
DYSVIATLNL NGDYISDALA AQVGGIGIAP GANISDQMAV FEATHGTAPK YAGQNKVNPG 

       370        380        390        400        410        420 
SIILSAEMML RHMGWYEAAD LIIRGMEGAI EAKTVTYDFE RGMQGATLVS SSGFADAMIK 


HM

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References

[1]"Whole-Genome Sequence of the Human Pathogen Legionella pneumophila Serogroup 12 Strain 570-CO-H."
Amaro F., Gilbert J.A., Owens S., Trimble W., Shuman H.A.
J. Bacteriol. 194:1613-1614(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: ATCC 43290 EMBL AEW51103.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP003192 Genomic DNA. Translation: AEW51103.1.
RefSeqYP_005185202.1. NC_016811.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEW51103; AEW51103; lp12_0833.
GeneID11802011.
KEGGlpe:lp12_0833.

Phylogenomic databases

KOK00031.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11835. PTHR11835. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR00183. prok_nadp_idh. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG8UXN8_LEGPN
AccessionPrimary (citable) accession number: G8UXN8
Entry history
Integrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: April 3, 2013
This is version 9 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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