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Protein
Submitted name:

2-oxoglutarate dehydrogenase E1 component

Gene

lp12_0537

Organism
Legionella pneumophila subsp. pneumophila ATCC 43290
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: InterPro
  2. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

BioCyciLPNE933093:GH6R-531-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
2-oxoglutarate dehydrogenase E1 componentImported
Gene namesi
ORF Names:lp12_0537Imported
OrganismiLegionella pneumophila subsp. pneumophila ATCC 43290Imported
Taxonomic identifieri933093 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella
ProteomesiUP000007851: Chromosome

Structurei

3D structure databases

ProteinModelPortaliG8USU1.
SMRiG8USU1. Positions 91-941.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

KOiK00164.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

G8USU1-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MNPLERMIMS SSDLQKEWAS SYLSGGSMAY VDSLYEDYLA DPDSVSEDWR
60 70 80 90 100
AVFSALPKVN GATKEVSHRD IREYFLQHAD KKLNKIIQIA DSQQYQVASL
110 120 130 140 150
INDFRSLGHL AAKLDPLEMT ERMPVPRLEL AYHNLADVDV NRTFFAGTSF
160 170 180 190 200
NGPEMTLGEI YNALRETYCR SIGIEYMHIS DTEVTEWLQN KMESVRGCPE
210 220 230 240 250
FSPQEKLNIL KDLIAADGLE RYLGTRYVGQ KRFSLEGGDS LIPMMKELIR
260 270 280 290 300
RSGINNVKEL VIGMAHRGRL NVLVNVLGKE PGLLFQEFEG KIKYERTGDV
310 320 330 340 350
KYHLGFSSDI KTESGAIVHL ALAFNPSHLE IIGPVVEGSV RSRLGRRNDL
360 370 380 390 400
AKKDKVVPIV IHGDAAFAGQ GVVMETFNFS QARGYCTGGT IHIVINNQIG
410 420 430 440 450
FTTSNPLDAR STLYCTDVAK MVQAPVIHVN GDDPEAVVFA TQVAFDFRMK
460 470 480 490 500
FKRDIVIDLV CYRRHGHNEA DEPSVTQPKM YKKIKSMPTL REKYGEQLVS
510 520 530 540 550
ANLLTKSEVD KLVDSYRETL DKGKAVVDLV HEDYEGKQSL DWTPYINAKW
560 570 580 590 600
TDKVDTTISK EELEKISSQL NKLPDGMKLH PVVERLLAER NKMTAGEIPM
610 620 630 640 650
NWGYAEIMAY ASLLHEGYGV RISGQDSGRG TFAHRHAVLH DIETGDTFIP
660 670 680 690 700
LEHISTSPKR YFTVIDSVLS EEAVLAFEYG FASSEPSFLV IWEAQFGDFA
710 720 730 740 750
NGAQVVIDQF ISSGEQKWGR LCGLVMLLPH GYEGQGPEHS SARLERYMQL
760 770 780 790 800
CAQHNIQVCT PTTPAQIFHL LRRQVIRNFR KPLIVMTPKS LLRHKLAVSP
810 820 830 840 850
LEALFKGKFH TVIPEIDALD AQKVTKVVLC CGKVYYDLLQ MRRDKNLNHV
860 870 880 890 900
AIVRIEQLYP FPKKALMAEL EKYQKANEVV WCQEEPQNQG VWFSSQHNMR
910 920 930 940
DCLRSDQTLQ YAGREFAAAP AVGSPGLHAE QQVALVEQAL LGKK
Length:944
Mass (Da):106,389
Last modified:February 22, 2012 - v1
Checksum:i1B82A26B37753D3E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003192 Genomic DNA. Translation: AEW50814.1.
RefSeqiWP_010946279.1. NC_016811.1.
YP_005184913.1. NC_016811.1.

Genome annotation databases

EnsemblBacteriaiAEW50814; AEW50814; lp12_0537.
GeneIDi11801720.
KEGGilpe:lp12_0537.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003192 Genomic DNA. Translation: AEW50814.1.
RefSeqiWP_010946279.1. NC_016811.1.
YP_005184913.1. NC_016811.1.

3D structure databases

ProteinModelPortaliG8USU1.
SMRiG8USU1. Positions 91-941.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEW50814; AEW50814; lp12_0537.
GeneIDi11801720.
KEGGilpe:lp12_0537.

Phylogenomic databases

KOiK00164.

Enzyme and pathway databases

BioCyciLPNE933093:GH6R-531-MONOMER.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Whole-Genome Sequence of the Human Pathogen Legionella pneumophila Serogroup 12 Strain 570-CO-H."
    Amaro F., Gilbert J.A., Owens S., Trimble W., Shuman H.A.
    J. Bacteriol. 194:1613-1614(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43290Imported.

Entry informationi

Entry nameiG8USU1_LEGPN
AccessioniPrimary (citable) accession number: G8USU1
Entry historyi
Integrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: January 7, 2015
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.