ID   G8UIQ1_TANFA            Unreviewed;       539 AA.
AC   G8UIQ1;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   27-MAR-2024, entry version 52.
DE   SubName: Full=BNR/Asp-box repeat protein {ECO:0000313|EMBL:AEW22573.1};
GN   OrderedLocusNames=BFO_2207 {ECO:0000313|EMBL:AEW22573.1};
OS   Tannerella forsythia (strain ATCC 43037 / JCM 10827 / CCUG 21028 A /
OS   KCTC 5666 / FDC 338) (Bacteroides forsythus).
OC   Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Tannerellaceae;
OC   Tannerella.
OX   NCBI_TaxID=203275 {ECO:0000313|EMBL:AEW22573.1, ECO:0000313|Proteomes:UP000005436};
RN   [1] {ECO:0000313|Proteomes:UP000005436}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43037 / JCM 10827 / CCUG 33226 / KCTC 5666 / FDC 338
RC   {ECO:0000313|Proteomes:UP000005436};
RA   Dewhirst F., Tanner A., Izard J., Brinkac L., Durkin A.S., Hostetler J.,
RA   Shetty J., Torralba M., Gill S., Nelson K.;
RT   "Complete sequence of Tannerella forsythia ATCC 43037.";
RL   Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0007829|PDB:7QXO, ECO:0007829|PDB:7QY8}
RP   X-RAY CRYSTALLOGRAPHY (1.66 ANGSTROMS) OF 21-539.
RX   PubMed=35916484; DOI=10.1042/bcj20220244;
RA   Satur M.J., Urbanowicz P.A., Spencer D.I.R., Rafferty J., Stafford G.P.;
RT   "Structural and functional characterisation of a stable, broad-specificity
RT   multimeric sialidase from the oral pathogen Tannerella forsythia.";
RL   Biochem. J. 479:1785-1806(2022).
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DR   EMBL; CP003191; AEW22573.1; -; Genomic_DNA.
DR   RefSeq; WP_014225510.1; NC_016610.1.
DR   PDB; 7QXO; X-ray; 1.90 A; A/B=21-539.
DR   PDB; 7QY8; X-ray; 2.06 A; A/B=21-539.
DR   PDB; 7QY9; X-ray; 1.92 A; A/B=21-539.
DR   PDB; 7QYJ; X-ray; 2.11 A; A/B=21-539.
DR   PDB; 7QYP; X-ray; 1.66 A; A/B=21-539.
DR   PDB; 7QZ3; X-ray; 1.97 A; A/B=21-539.
DR   AlphaFoldDB; G8UIQ1; -.
DR   SMR; G8UIQ1; -.
DR   STRING; 203275.BFO_2207; -.
DR   GeneID; 34759268; -.
DR   KEGG; tfo:BFO_2207; -.
DR   PATRIC; fig|203275.8.peg.2003; -.
DR   eggNOG; COG4409; Bacteria.
DR   HOGENOM; CLU_024620_0_0_10; -.
DR   Proteomes; UP000005436; Chromosome.
DR   GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   Gene3D; 2.60.40.1290; -; 1.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR029456; Sialidase_N.
DR   InterPro; IPR036278; Sialidase_sf.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF19; SIALIDASE; 1.
DR   Pfam; PF13859; BNR_3; 1.
DR   Pfam; PF14873; BNR_assoc_N; 1.
DR   SUPFAM; SSF50939; Sialidases; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:7QXO, ECO:0007829|PDB:7QY8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005436}.
FT   DOMAIN          20..169
FT                   /note="Sialidase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF14873"
FT   DOMAIN          200..478
FT                   /note="Sialidase"
FT                   /evidence="ECO:0000259|Pfam:PF13859"
SQ   SEQUENCE   539 AA;  59687 MW;  7442B2CB9D8853DB CRC64;
     MKKFFWIIGL FASMQMTRAA DSVYVQNPQI PILVDRTDNV LFRIRIPDAT KGDVLNRLTI
     RFGNEDKLSE VKAVRLFYAG TEAATKGRSR FAPVTYVSSH NIRNTRSANP SYSIRQDEVT
     TVANTLTLKT RQPMVKGINY FWVSVEMDRN TSLLSKLTST VTEVVINDKP AVIAGEQAAV
     RRMGIGVRHA GDDGSASFRI PGLVTTNKGT LLGVYDVRYN NSVDLQEHID VGLSRSTDKG
     QTWEPMRIAM SFGETDGLPS GQNGVGDPSI LVDERTNTVW VVAAWTHGMG NARAWTNSMP
     GMTPDETAQL MMVKSTDDGR TWSESTNITS QVKDPSWCFL LQGPGRGITM RDGTLVFPIQ
     FIDSLRVPHA GIMYSKDRGE TWHIHQPART NTTEAQVAEV EPGVLMLNMR DNRGGSRAVS
     ITRDLGKSWT EHSSNRSALP ESICMASLIS VKAKDNIIGK DLLLFSNPNT TEGRHHITIK
     ASLDGGVTWL PAHQVLLDEE DGWGYSCLSM IDRETVGIFY ESSVAHMTFQ AVKIKDLIR
//