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G8UIG9

- G8UIG9_TANFA

UniProt

G8UIG9 - G8UIG9_TANFA

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Protein
ATP-dependent 6-phosphofructokinase
Gene
pfkA, BFO_1157
Organism
Tannerella forsythia (strain ATCC 43037 / JCM 10827 / FDC 338) (Bacteroides forsythus)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis By similarity.UniRule annotationSAAS annotations

Catalytic activityi

ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate.UniRule annotationSAAS annotations

Cofactori

Magnesium By similarity.UniRule annotationSAAS annotations

Enzyme regulationi

Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei24 – 241ATP; via amide nitrogen By similarityUniRule annotation
Metal bindingi116 – 1161Magnesium; catalytic By similarityUniRule annotation
Active sitei141 – 1411Proton acceptor By similarityUniRule annotation
Binding sitei168 – 1681Allosteric activator ADP By similarityUniRule annotation
Binding sitei176 – 1761Substrate; shared with dimeric partner By similarityUniRule annotation
Binding sitei225 – 2251Allosteric activator ADP By similarityUniRule annotation
Binding sitei236 – 2361Substrate By similarityUniRule annotation
Binding sitei260 – 2601Substrate; shared with dimeric partner By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi85 – 862ATP By similarityUniRule annotation
Nucleotide bindingi115 – 1184ATP By similarityUniRule annotation

GO - Molecular functioni

  1. 6-phosphofructokinase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. fructose 6-phosphate metabolic process Source: InterPro
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

GlycolysisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, MagnesiumUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding

Enzyme and pathway databases

BioCyciTFOR203275:GHRQ-1155-MONOMER.
UniPathwayiUPA00109; UER00182.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent 6-phosphofructokinaseUniRule annotation (EC:2.7.1.11UniRule annotation)
Short name:
ATP-PFKUniRule annotation
Short name:
PhosphofructokinaseUniRule annotation
Alternative name(s):
Phosphohexokinase
Gene namesi
Name:pfkAUniRule annotationImported
Ordered Locus Names:BFO_1157Imported
OrganismiTannerella forsythia (strain ATCC 43037 / JCM 10827 / FDC 338) (Bacteroides forsythus)Imported
Taxonomic identifieri203275 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaeTannerella
ProteomesiUP000005436: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. 6-phosphofructokinase complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotationSAAS annotations

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni34 – 385Allosteric activator ADP binding; shared with dimeric partner By similarityUniRule annotation
Regioni139 – 1413Substrate binding By similarityUniRule annotation
Regioni183 – 1853Substrate binding By similarityUniRule annotation
Regioni199 – 2013Allosteric activator ADP binding By similarityUniRule annotation
Regioni227 – 2293Allosteric activator ADP binding By similarityUniRule annotation
Regioni266 – 2694Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

KOiK00850.

Family and domain databases

HAMAPiMF_00339. Phosphofructokinase.
InterProiIPR012003. ATP_PFK_prok.
IPR012828. PFKA_ATP.
IPR022953. Phosphofructokinase.
IPR015912. Phosphofructokinase_CS.
IPR000023. Phosphofructokinase_dom.
[Graphical view]
PfamiPF00365. PFK. 1 hit.
[Graphical view]
PIRSFiPIRSF000532. ATP_PFK_prok. 1 hit.
PRINTSiPR00476. PHFRCTKINASE.
SUPFAMiSSF53784. SSF53784. 1 hit.
TIGRFAMsiTIGR02482. PFKA_ATP. 1 hit.
PROSITEiPS00433. PHOSPHOFRUCTOKINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G8UIG9-1 [UniParc]FASTAAdd to Basket

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MGFKLIRSNM STKIKCIGLL TSGGDAPGMN AAIRAVTRTA IYNGMAVKGI    50
YRGYKGLITN EIEDFKTQSV SNIIQRGGTI LKTARCAEFQ TSEGRKLAYD 100
VILQHGINAM IVIGGDGSLR GARDFAQEYD FPIIGLPGTI DNDLNGTDTT 150
IGYDTALNTI MECVDKIRDT ASSHERLFFV EVMGRDAGFL ALNGAIASGA 200
EAAIIPEISL KKDQLAEMIE MGFRKSKNSS IVLVAESEVT GGAMGVAERV 250
KKQYPGFDVR VSILGHLQRG GSPTAQDRIL STRMGVAAVD ALIEGQRNAM 300
VGIQNEELTL VPFVKAIKKD KPINRDLLNV LRIVST 336
Length:336
Mass (Da):36,204
Last modified:February 22, 2012 - v1
Checksum:iD005340F009D9E0B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003191 Genomic DNA. Translation: AEW22384.1.
RefSeqiYP_005014063.1. NC_016610.1.

Genome annotation databases

EnsemblBacteriaiAEW22384; AEW22384; BFO_1157.
GeneIDi11658166.
KEGGitfo:BFO_1157.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003191 Genomic DNA. Translation: AEW22384.1 .
RefSeqi YP_005014063.1. NC_016610.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEW22384 ; AEW22384 ; BFO_1157 .
GeneIDi 11658166.
KEGGi tfo:BFO_1157.

Phylogenomic databases

KOi K00850.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00182 .
BioCyci TFOR203275:GHRQ-1155-MONOMER.

Family and domain databases

HAMAPi MF_00339. Phosphofructokinase.
InterProi IPR012003. ATP_PFK_prok.
IPR012828. PFKA_ATP.
IPR022953. Phosphofructokinase.
IPR015912. Phosphofructokinase_CS.
IPR000023. Phosphofructokinase_dom.
[Graphical view ]
Pfami PF00365. PFK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000532. ATP_PFK_prok. 1 hit.
PRINTSi PR00476. PHFRCTKINASE.
SUPFAMi SSF53784. SSF53784. 1 hit.
TIGRFAMsi TIGR02482. PFKA_ATP. 1 hit.
PROSITEi PS00433. PHOSPHOFRUCTOKINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Tannerella forsythia ATCC 43037."
    Dewhirst F., Tanner A., Izard J., Brinkac L., Durkin A.S., Hostetler J., Shetty J., Torralba M., Gill S., Nelson K.
    Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43037 / JCM 10827 / FDC 338.

Entry informationi

Entry nameiG8UIG9_TANFA
AccessioniPrimary (citable) accession number: G8UIG9
Entry historyi
Integrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: July 9, 2014
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Allosteric enzymeUniRule annotation, Complete proteome

External Data

Dasty 3

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