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G8UA07 (G8UA07_BACCE) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 10. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Tyrosine--tRNA ligase HAMAP-Rule MF_02006
EC=6.1.1.1 HAMAP-Rule MF_02006
Alternative name(s):
Tyrosyl-tRNA synthetase HAMAP-Rule MF_02006
Gene names
Name:tyrS HAMAP-Rule MF_02006
ORF Names:bcf_25450 EMBL AEW58184.1
OrganismBacillus cereus F837/76 EMBL AEW58184.1
Taxonomic identifier347495 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group ›

Protein attributes

Sequence length419 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) By similarity. HAMAP-Rule MF_02006 SAAS SAAS002307

Catalytic activity

ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr). HAMAP-Rule MF_02006 SAAS SAAS002307

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_02006 SAAS SAAS002307

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_02006 SAAS SAAS002307.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. HAMAP-Rule MF_02006

Contains 1 S4 RNA-binding domain. HAMAP-Rule MF_02006 SAAS SAAS002307

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain352 – 41867S4 RNA-binding By similarity HAMAP-Rule MF_02006
Motif39 – 4810"HIGH" region By similarity HAMAP-Rule MF_02006
Motif230 – 2345"KMSKS" region By similarity HAMAP-Rule MF_02006

Sites

Binding site341Tyrosine By similarity HAMAP-Rule MF_02006
Binding site1681Tyrosine By similarity HAMAP-Rule MF_02006
Binding site1721Tyrosine By similarity HAMAP-Rule MF_02006
Binding site2331ATP By similarity HAMAP-Rule MF_02006

Sequences

Sequence LengthMass (Da)Tools
G8UA07 [UniParc].

Last modified February 22, 2012. Version 1.
Checksum: 24A058568CF747C3

FASTA41947,384
        10         20         30         40         50         60 
MNIIDELEWR GAVNQQTDEE GLRKLVEEKK ISLYCGVDPT GDSMHIGHLI PFMMMKRFQL 

        70         80         90        100        110        120 
AGHHPVILIG GATGTIGDPS GRQSERQLQT LEVVQHNVDA LTAQMKKLFD FGGNSEVKMV 

       130        140        150        160        170        180 
NNYDWTHEIN IIEFLRDYGK NFSINSMLAK DIVASRLDTG ISFTEFTYQI LQAMDFHHLY 

       190        200        210        220        230        240 
TKEDVQLQIG GSDQWGNITS GLDLIRKLEG HEAKVFGLTI PLLLKSDGTK FGKSAGGAVW 

       250        260        270        280        290        300 
LDPEKTTPFE FYQFWVNTDD RDVVKYLKYF TFLTKERIDE LAVKVETEPH KREAQKVLAE 

       310        320        330        340        350        360 
EMTKFVHGEE AFLQAVKITA ALFSGDIKSL TADEIEQGFK EMPTFQSSKE TKNIVEWLVD 

       370        380        390        400        410 
LGIEPSRRQA REDINNGAIS MNGEKVTDVG TDVTVENSFD GRFIIIRKGK KNYSLVKLG

« Hide

References

[1]"Complete Genome Sequence of the Highly Hemolytic Strain Bacillus cereus F837/76."
Auger S., Galleron N., Segurens B., Dossat C., Bolotin A., Wincker P., Sorokin A.
J. Bacteriol. 194:1630-1630(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: F837/76 EMBL AEW58184.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP003187 Genomic DNA. Translation: AEW58184.1.
RefSeqYP_005121697.1. NC_016779.1.

3D structure databases

ProteinModelPortalG8UA07.
SMRG8UA07. Positions 2-319.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEW58184; AEW58184; bcf_25450.
GeneID11680788.
KEGGbcf:bcf_25450.

Phylogenomic databases

KOK01866.

Family and domain databases

Gene3D3.10.290.10. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_02006. Tyr_tRNA_synth_type1.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002942. S4_RNA-bd.
IPR002307. Tyr-tRNA-ligase.
IPR024088. Tyr-tRNA-ligase_bac-type.
IPR024107. Tyr-tRNA-ligase_bac_1.
[Graphical view]
PANTHERPTHR11766. PTHR11766. 1 hit.
PfamPF01479. S4. 1 hit.
PF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSPR01040. TRNASYNTHTYR.
SMARTSM00363. S4. 1 hit.
[Graphical view]
TIGRFAMsTIGR00234. tyrS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
PS50889. S4. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG8UA07_BACCE
AccessionPrimary (citable) accession number: G8UA07
Entry history
Integrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: April 3, 2013
This is version 10 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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