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G8U432

- G8U432_BACCE

UniProt

G8U432 - G8U432_BACCE

Protein

Isocitrate dehydrogenase [NADP]

Gene

bcf_23005

Organism
Bacillus cereus F837/76
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 15 (01 Oct 2014)
      Sequence version 1 (22 Feb 2012)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation
    Binds 1 magnesium or manganese ion per subunit By similarity.

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciBCER347495:GHGC-4601-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    ORF Names:bcf_23005Imported
    OrganismiBacillus cereus F837/76Imported
    Taxonomic identifieri347495 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
    ProteomesiUP000007854: Chromosome

    Structurei

    3D structure databases

    ProteinModelPortaliG8U432.
    SMRiG8U432. Positions 1-423.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    KOiK00031.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G8U432-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTGEKITVT NGVMNVPNNP IIPFIEGDGI GPDIWAAASR VLEAAVEKAY    50
    DGEKKIVWKE VLAGEKAFNQ TGEWLPEETL NLIREYLIAI KGPLTTPVGG 100
    GIRSLNVALR QELDLYVCLR PVRYFEGVPS PVKRPEDTDM VIFRENTEDI 150
    YAGIEYAQGS PEAEKVLAFL KEAMGVNKIR FPETSGIGIK PISEEGTKRL 200
    VRAAIQYAIN EKRSSVTLVH KGNIMKFTEG AFKNWGYEVA EQEFGDKVFT 250
    WAEYDRIVEK DGKDAANKAM ADAEVAGKII VKDSIADIFL QQILTRPREF 300
    DVVATMNLNG DYISDALAAQ VGGIGIAPGA NINYVTGHAI FEATHGTAPK 350
    YAGLDKVNPS SVLLSGVLLL EHLGWNEAAK LVTASVEKTI ASKVVTYDFA 400
    RLMEGATEVK CSEFANELIK NMDVAIIKNA 430
    Length:430
    Mass (Da):46,973
    Last modified:February 22, 2012 - v1
    Checksum:i2238E99660A705F3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003187 Genomic DNA. Translation: AEW57720.1.
    RefSeqiYP_005121233.1. NC_016779.1.

    Genome annotation databases

    EnsemblBacteriaiAEW57720; AEW57720; bcf_23005.
    GeneIDi11678188.
    KEGGibcf:bcf_23005.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003187 Genomic DNA. Translation: AEW57720.1 .
    RefSeqi YP_005121233.1. NC_016779.1.

    3D structure databases

    ProteinModelPortali G8U432.
    SMRi G8U432. Positions 1-423.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEW57720 ; AEW57720 ; bcf_23005 .
    GeneIDi 11678188.
    KEGGi bcf:bcf_23005.

    Phylogenomic databases

    KOi K00031.

    Enzyme and pathway databases

    BioCyci BCER347495:GHGC-4601-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete Genome Sequence of the Highly Hemolytic Strain Bacillus cereus F837/76."
      Auger S., Galleron N., Segurens B., Dossat C., Bolotin A., Wincker P., Sorokin A.
      J. Bacteriol. 194:1630-1630(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: F837/76Imported.

    Entry informationi

    Entry nameiG8U432_BACCE
    AccessioniPrimary (citable) accession number: G8U432
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 22, 2012
    Last sequence update: February 22, 2012
    Last modified: October 1, 2014
    This is version 15 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3