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G8TVL4

- G8TVL4_SULAD

UniProt

G8TVL4 - G8TVL4_SULAD

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Protein
Kynureninase
Gene
kynU, Sulac_0080
Organism
Sulfobacillus acidophilus (strain ATCC 700253 / DSM 10332 / NAL)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively By similarity.UniRule annotation

Catalytic activityi

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei101 – 1011Pyridoxal phosphate; via amide nitrogen By similarityUniRule annotation
Binding sitei102 – 1021Pyridoxal phosphate By similarityUniRule annotation
Binding sitei210 – 2101Pyridoxal phosphate By similarityUniRule annotation
Binding sitei213 – 2131Pyridoxal phosphate By similarityUniRule annotation
Binding sitei235 – 2351Pyridoxal phosphate By similarityUniRule annotation
Binding sitei264 – 2641Pyridoxal phosphate By similarityUniRule annotation
Binding sitei292 – 2921Pyridoxal phosphate By similarityUniRule annotation

GO - Molecular functioni

  1. kynureninase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. L-kynurenine catabolic process Source: UniProtKB-UniPathway
  3. anthranilate metabolic process Source: UniProtKB-HAMAP
  4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  5. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationImported

Keywords - Biological processi

Pyridine nucleotide biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciSACI679936:GHYT-83-MONOMER.
UniPathwayiUPA00253; UER00329.
UPA00334; UER00455.

Names & Taxonomyi

Protein namesi
Recommended name:
KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
Alternative name(s):
L-kynurenine hydrolase
Gene namesi
Name:kynUUniRule annotation
Ordered Locus Names:Sulac_0080Imported
OrganismiSulfobacillus acidophilus (strain ATCC 700253 / DSM 10332 / NAL)Imported
Taxonomic identifieri679936 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiales Family XVII. Incertae SedisSulfobacillus
ProteomesiUP000005439: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei236 – 2361N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni129 – 1324Pyridoxal phosphate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

KOiK01556.
OMAiVWDLAHS.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01970. Kynureninase.
InterProiIPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01814. kynureninase. 1 hit.

Sequencei

Sequence statusi: Complete.

G8TVL4-1 [UniParc]FASTAAdd to Basket

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MSFTLSRQFA ETEDRNDPLA PYRRLFPPAA ERIYLAGNSL GLWSERAEQS    50
LMAVLESWRH HGVDGWSHGP YPWFDLSERL GRLMVPLVGA NPHEVIVTGS 100
TTVNLHQLLA TFYRPRGRRI KILTDSLAFP SDIYAIKSHI TLHGLTVEEA 150
LIEVASPDGL TLDENAVIQA MTDDVALVIL PSVLFVSGQR LDMATLTAAA 200
HDRGILIGFD LAHSVGIMPH QLSAWGVDFA FWCTYKYLNG GPGSVGALYV 250
ADRHLPKTPG LAGWFSSDKA VQFDMAHTLV PSSDAGAFQI GTPHILSLAP 300
LMGSLEMFRE IPIETIRDKS LRLTRYLMDL VNHRLADRGF RIVTPLQDAR 350
RGGHVALAHP DAIRISKALK ARQVIPDYRP PRIIRLAPSP LYTTYQDVWD 400
TVNHLWEIME YREYERYSPE REVVS 425
Length:425
Mass (Da):47,635
Last modified:February 22, 2012 - v1
Checksum:i2C3BA4380AAAF947
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003179 Genomic DNA. Translation: AEW03653.1.
RefSeqiWP_014344549.1. NC_016884.1.
YP_005255325.1. NC_016884.1.

Genome annotation databases

EnsemblBacteriaiAEW03653; AEW03653; Sulac_0080.
GeneIDi11856809.
KEGGisap:Sulac_0080.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003179 Genomic DNA. Translation: AEW03653.1 .
RefSeqi WP_014344549.1. NC_016884.1.
YP_005255325.1. NC_016884.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEW03653 ; AEW03653 ; Sulac_0080 .
GeneIDi 11856809.
KEGGi sap:Sulac_0080.

Phylogenomic databases

KOi K01556.
OMAi VWDLAHS.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00329 .
UPA00334 ; UER00455 .
BioCyci SACI679936:GHYT-83-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_01970. Kynureninase.
InterProi IPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR14084. PTHR14084. 1 hit.
Pfami PF00266. Aminotran_5. 1 hit.
[Graphical view ]
PIRSFi PIRSF038800. KYNU. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01814. kynureninase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700253 / DSM 10332 / NAL.

Entry informationi

Entry nameiG8TVL4_SULAD
AccessioniPrimary (citable) accession number: G8TVL4
Entry historyi
Integrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: September 3, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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