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G8TGD7

- G8TGD7_NIAKG

UniProt

G8TGD7 - G8TGD7_NIAKG

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Protein
ATP-dependent 6-phosphofructokinase
Gene
pfkA, Niako_0981
Organism
Niastella koreensis (strain DSM 17620 / KACC 11465 / GR20-10)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis By similarity.UniRule annotationSAAS annotations

Catalytic activityi

ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate.UniRule annotationSAAS annotations

Cofactori

Magnesium By similarity.UniRule annotationSAAS annotations

Enzyme regulationi

Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei15 – 151ATP; via amide nitrogen By similarityUniRule annotation
Metal bindingi107 – 1071Magnesium; catalytic By similarityUniRule annotation
Active sitei132 – 1321Proton acceptor By similarityUniRule annotation
Binding sitei159 – 1591Allosteric activator ADP By similarityUniRule annotation
Binding sitei167 – 1671Substrate; shared with dimeric partner By similarityUniRule annotation
Binding sitei216 – 2161Allosteric activator ADP By similarityUniRule annotation
Binding sitei227 – 2271Substrate By similarityUniRule annotation
Binding sitei251 – 2511Substrate; shared with dimeric partner By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi76 – 772ATP By similarityUniRule annotation
Nucleotide bindingi106 – 1094ATP By similarityUniRule annotation

GO - Molecular functioni

  1. 6-phosphofructokinase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. fructose 6-phosphate metabolic process Source: InterPro
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

GlycolysisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, MagnesiumUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding

Enzyme and pathway databases

BioCyciNKOR700598:GHC3-996-MONOMER.
UniPathwayiUPA00109; UER00182.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent 6-phosphofructokinaseUniRule annotation (EC:2.7.1.11UniRule annotation)
Short name:
ATP-PFKUniRule annotation
Short name:
PhosphofructokinaseUniRule annotation
Alternative name(s):
Phosphohexokinase
Gene namesi
Name:pfkAUniRule annotation
Ordered Locus Names:Niako_0981Imported
OrganismiNiastella koreensis (strain DSM 17620 / KACC 11465 / GR20-10)Imported
Taxonomic identifieri700598 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesSphingobacteriiaSphingobacterialesChitinophagaceaeNiastella
ProteomesiUP000005438: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. 6-phosphofructokinase complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotationSAAS annotations

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni25 – 295Allosteric activator ADP binding; shared with dimeric partner By similarityUniRule annotation
Regioni130 – 1323Substrate binding By similarityUniRule annotation
Regioni174 – 1763Substrate binding By similarityUniRule annotation
Regioni190 – 1923Allosteric activator ADP binding By similarityUniRule annotation
Regioni218 – 2203Allosteric activator ADP binding By similarityUniRule annotation
Regioni257 – 2604Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

KOiK00850.
OMAiGFGGRCV.

Family and domain databases

HAMAPiMF_00339. Phosphofructokinase.
InterProiIPR012003. ATP_PFK_prok.
IPR012828. PFKA_ATP.
IPR022953. Phosphofructokinase.
IPR015912. Phosphofructokinase_CS.
IPR000023. Phosphofructokinase_dom.
[Graphical view]
PfamiPF00365. PFK. 1 hit.
[Graphical view]
PIRSFiPIRSF000532. ATP_PFK_prok. 1 hit.
PRINTSiPR00476. PHFRCTKINASE.
SUPFAMiSSF53784. SSF53784. 1 hit.
TIGRFAMsiTIGR02482. PFKA_ATP. 1 hit.
PROSITEiPS00433. PHOSPHOFRUCTOKINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G8TGD7-1 [UniParc]FASTAAdd to Basket

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MAKKVTKIGV LTSGGDSPGM NAAIRAVVRT GNYYGLEVFG IMRGYSGIID    50
NDIVPMHSRS VANIIQRGGT ILKTARCKEF FTPEGRLKAY NNLKKLGIDG 100
LVIIGGDGSF RGADIFSREF DIPCIGLPGT IDKDIAGTDF TIGFDTAVNT 150
AVEAIDKIRD TADAHDRLFI IEVMGRDAGY IALHSGIATG AEHILIPERK 200
TDIEELVASL QEKERRKKLV NMVVVAEGDE FGGANEVAKV VKERLPTTDT 250
RVCILGHIQR GGSPTCLDRL IASRMGYAAV ESLLEGRHNV MVGILNNRMH 300
YTLLERAVKS KQKISDEWIK IVKILAS 327
Length:327
Mass (Da):35,611
Last modified:February 22, 2012 - v1
Checksum:iB9021465E65CCEF7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003178 Genomic DNA. Translation: AEV97360.1.
RefSeqiWP_014217274.1. NC_016609.1.
YP_005006764.1. NC_016609.1.

Genome annotation databases

EnsemblBacteriaiAEV97360; AEV97360; Niako_0981.
GeneIDi11652727.
KEGGinko:Niako_0981.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003178 Genomic DNA. Translation: AEV97360.1 .
RefSeqi WP_014217274.1. NC_016609.1.
YP_005006764.1. NC_016609.1.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEV97360 ; AEV97360 ; Niako_0981 .
GeneIDi 11652727.
KEGGi nko:Niako_0981.

Phylogenomic databases

KOi K00850.
OMAi GFGGRCV.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00182 .
BioCyci NKOR700598:GHC3-996-MONOMER.

Family and domain databases

HAMAPi MF_00339. Phosphofructokinase.
InterProi IPR012003. ATP_PFK_prok.
IPR012828. PFKA_ATP.
IPR022953. Phosphofructokinase.
IPR015912. Phosphofructokinase_CS.
IPR000023. Phosphofructokinase_dom.
[Graphical view ]
Pfami PF00365. PFK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000532. ATP_PFK_prok. 1 hit.
PRINTSi PR00476. PHFRCTKINASE.
SUPFAMi SSF53784. SSF53784. 1 hit.
TIGRFAMsi TIGR02482. PFKA_ATP. 1 hit.
PROSITEi PS00433. PHOSPHOFRUCTOKINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 17620 / KACC 11465 / GR20-10.

Entry informationi

Entry nameiG8TGD7_NIAKG
AccessioniPrimary (citable) accession number: G8TGD7
Entry historyi
Integrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: September 3, 2014
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Allosteric enzymeUniRule annotation, Complete proteome

External Data

Dasty 3

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