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Protein

Thymidine kinase

Gene

tdk

Organism
Niastella koreensis (strain DSM 17620 / KACC 11465 / GR20-10)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei93Proton acceptorUniRule annotation1
Metal bindingi149ZincUniRule annotation1
Metal bindingi152ZincUniRule annotation1
Metal bindingi181ZincUniRule annotation1
Metal bindingi184ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi20 – 27ATPUniRule annotation8
Nucleotide bindingi92 – 95ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processDNA synthesisUniRule annotation
LigandATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Enzyme and pathway databases

BioCyciNKOR700598:G1H35-4977-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:Niako_5031Imported
OrganismiNiastella koreensis (strain DSM 17620 / KACC 11465 / GR20-10)Imported
Taxonomic identifieri700598 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesChitinophagiaChitinophagalesChitinophagaceaeNiastella
Proteomesi
  • UP000005438 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi700598.Niako_5031

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107T8J Bacteria
COG1435 LUCA
KOiK00857
OMAiKEQFGWI
OrthoDBiPOG091H0659

Family and domain databases

HAMAPiMF_00124 Thymidine_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR001267 Thymidine_kinase
IPR020633 Thymidine_kinase_CS
PANTHERiPTHR11441 PTHR11441, 2 hits
PfamiView protein in Pfam
PF00265 TK, 1 hit
PIRSFiPIRSF035805 TK_cell, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00603 TK_CELLULAR_TYPE, 1 hit

Sequencei

Sequence statusi: Complete.

G8T9S6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFIEPNISGE RRGSIEVICG SMFSGKTEEL IRRLKRAKIA NLRVEIFKPK
60 70 80 90 100
IDVRYDVHNI VSHDENAILS TPIDNSQTIL LLHNEADVIG IDEAQFFDDQ
110 120 130 140 150
LPDVCDQLAL RGHRVIVAGL DMDYTGKPFG QIPFLLSKAD YITKLHAICV
160 170 180 190
KCGHIANYSF RKKADKTQVL LGEKDVYEPR CRKCYYEGAV ENG
Length:193
Mass (Da):21,842
Last modified:February 22, 2012 - v1
Checksum:iB48AF196D0EAD18B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003178 Genomic DNA Translation: AEW01270.1
RefSeqiWP_014221181.1, NC_016609.1

Genome annotation databases

EnsemblBacteriaiAEW01270; AEW01270; Niako_5031
KEGGinko:Niako_5031
PATRICifig|700598.3.peg.5142

Similar proteinsi

Entry informationi

Entry nameiG8T9S6_NIAKG
AccessioniPrimary (citable) accession number: G8T9S6
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: March 28, 2018
This is version 36 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health