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G8SIJ9

- G8SIJ9_ACTS5

UniProt

G8SIJ9 - G8SIJ9_ACTS5

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Protein

Isocitrate dehydrogenase [NADP]

Gene
icdA, ACPL_900
Organism
Actinoplanes sp. (strain ATCC 31044 / CBS 674.73 / SE50/110)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei77 – 771Substrate By similarityUniRule annotation
Binding sitei82 – 821NADP By similarity
Binding sitei109 – 1091Substrate By similarityUniRule annotation
Binding sitei132 – 1321Substrate By similarityUniRule annotation
Sitei139 – 1391Critical for catalysis By similarityUniRule annotation
Sitei211 – 2111Critical for catalysis By similarityUniRule annotation
Metal bindingi251 – 2511Magnesium or manganese By similarityUniRule annotation
Binding sitei259 – 2591NADP By similarity
Metal bindingi274 – 2741Magnesium or manganese By similarityUniRule annotation
Binding sitei327 – 3271NADP; via amide nitrogen and carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi75 – 773NADP By similarity
Nucleotide bindingi309 – 3146NADP By similarity

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciASP134676:GL7H-806-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:icdAImported
Ordered Locus Names:ACPL_900Imported
OrganismiActinoplanes sp. (strain ATCC 31044 / CBS 674.73 / SE50/110)Imported
Taxonomic identifieri134676 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicromonosporineaeMicromonosporaceaeActinoplanes
ProteomesiUP000005440: Chromosome

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni94 – 1007Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

KOiK00031.
OMAiKNTIMKV.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G8SIJ9-1 [UniParc]FASTAAdd to Basket

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MAKIKVKNPV VEIDGDEMTR IIWKQIREQL IQPYLDVNLE YYDLGIQYRD    50
ETDDQVTIDA ANAIKRHGVG VKCATITPDE ARVQEFGLKK MWRSPNGTIR 100
NILGGVVFRE PIIMKNVPRL VPGWTKPIVI GRHAHGDQYK ASDFVAPSKG 150
KMTVTFTPED GSAPIEMHVA DFPAGGVGMA MYNFDESIRD FARASLRYGL 200
ARNYPVYLST KNTILKAYDG RFKDLFAEIF ETEFADQFKE AGITYEHRLI 250
DDMVAAALKW EGGYVWACKN YDGDVQSDTV AQGFGSLGLM TSVLMTPDGQ 300
TVEAEAAHGT VTRHYRQWQK GEKTSTNPIA SIFAWTGGLK HRGKLDGTPE 350
VTQFAEALEQ VCIETVEGGQ MTKDLALLIS KDAPWLSTDE FMNALDENLA 400
RKLA 404
Length:404
Mass (Da):45,116
Last modified:February 22, 2012 - v1
Checksum:i59E08A6AD06C89AE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003170 Genomic DNA. Translation: AEV81797.1.
RefSeqiWP_014687870.1. NC_017803.1.
YP_006263865.1. NC_017803.1.

Genome annotation databases

EnsemblBacteriaiAEV81797; AEV81797; ACPL_900.
GeneIDi12821715.
KEGGiase:ACPL_900.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003170 Genomic DNA. Translation: AEV81797.1 .
RefSeqi WP_014687870.1. NC_017803.1.
YP_006263865.1. NC_017803.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEV81797 ; AEV81797 ; ACPL_900 .
GeneIDi 12821715.
KEGGi ase:ACPL_900.

Phylogenomic databases

KOi K00031.
OMAi KNTIMKV.

Enzyme and pathway databases

BioCyci ASP134676:GL7H-806-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of the acarbose producer Actinoplanes sp. SE50/110."
    Schwientek P., Szczepanowski R., Kalinowski J., Klein A., Selber K., Wehmeier U.F., Stoye J., Puehler A.
    Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 31044 / CBS 674.73 / SE50/110.

Entry informationi

Entry nameiG8SIJ9_ACTS5
AccessioniPrimary (citable) accession number: G8SIJ9
Entry historyi
Integrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: September 3, 2014
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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