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G8SIJ9

- G8SIJ9_ACTS5

UniProt

G8SIJ9 - G8SIJ9_ACTS5

Protein

Isocitrate dehydrogenase [NADP]

Gene

icdA

Organism
Actinoplanes sp. (strain ATCC 31044 / CBS 674.73 / SE50/110)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 16 (01 Oct 2014)
      Sequence version 1 (22 Feb 2012)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei77 – 771SubstrateUniRule annotation
    Binding sitei82 – 821NADPUniRule annotation
    Binding sitei109 – 1091SubstrateUniRule annotation
    Binding sitei132 – 1321SubstrateUniRule annotation
    Sitei139 – 1391Critical for catalysisUniRule annotation
    Sitei211 – 2111Critical for catalysis
    Metal bindingi251 – 2511Magnesium or manganeseUniRule annotation
    Binding sitei259 – 2591NADPUniRule annotation
    Metal bindingi274 – 2741Magnesium or manganeseUniRule annotation
    Binding sitei327 – 3271NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi75 – 773NADPUniRule annotation
    Nucleotide bindingi309 – 3146NADPUniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. isocitrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciASP134676:GL7H-806-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Name:icdAImported
    Ordered Locus Names:ACPL_900Imported
    OrganismiActinoplanes sp. (strain ATCC 31044 / CBS 674.73 / SE50/110)Imported
    Taxonomic identifieri134676 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicromonosporineaeMicromonosporaceaeActinoplanes
    ProteomesiUP000005440: Chromosome

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni94 – 1007Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    KOiK00031.
    OMAiKNTIMKV.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11822. PTHR11822. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G8SIJ9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKIKVKNPV VEIDGDEMTR IIWKQIREQL IQPYLDVNLE YYDLGIQYRD    50
    ETDDQVTIDA ANAIKRHGVG VKCATITPDE ARVQEFGLKK MWRSPNGTIR 100
    NILGGVVFRE PIIMKNVPRL VPGWTKPIVI GRHAHGDQYK ASDFVAPSKG 150
    KMTVTFTPED GSAPIEMHVA DFPAGGVGMA MYNFDESIRD FARASLRYGL 200
    ARNYPVYLST KNTILKAYDG RFKDLFAEIF ETEFADQFKE AGITYEHRLI 250
    DDMVAAALKW EGGYVWACKN YDGDVQSDTV AQGFGSLGLM TSVLMTPDGQ 300
    TVEAEAAHGT VTRHYRQWQK GEKTSTNPIA SIFAWTGGLK HRGKLDGTPE 350
    VTQFAEALEQ VCIETVEGGQ MTKDLALLIS KDAPWLSTDE FMNALDENLA 400
    RKLA 404
    Length:404
    Mass (Da):45,116
    Last modified:February 22, 2012 - v1
    Checksum:i59E08A6AD06C89AE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003170 Genomic DNA. Translation: AEV81797.1.
    RefSeqiWP_014687870.1. NC_017803.1.
    YP_006263865.1. NC_017803.1.

    Genome annotation databases

    EnsemblBacteriaiAEV81797; AEV81797; ACPL_900.
    GeneIDi12821715.
    KEGGiase:ACPL_900.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003170 Genomic DNA. Translation: AEV81797.1 .
    RefSeqi WP_014687870.1. NC_017803.1.
    YP_006263865.1. NC_017803.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEV81797 ; AEV81797 ; ACPL_900 .
    GeneIDi 12821715.
    KEGGi ase:ACPL_900.

    Phylogenomic databases

    KOi K00031.
    OMAi KNTIMKV.

    Enzyme and pathway databases

    BioCyci ASP134676:GL7H-806-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11822. PTHR11822. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of the acarbose producer Actinoplanes sp. SE50/110."
      Schwientek P., Szczepanowski R., Kalinowski J., Klein A., Selber K., Wehmeier U.F., Stoye J., Puehler A.
      Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 31044 / CBS 674.73 / SE50/110Imported.

    Entry informationi

    Entry nameiG8SIJ9_ACTS5
    AccessioniPrimary (citable) accession number: G8SIJ9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 22, 2012
    Last sequence update: February 22, 2012
    Last modified: October 1, 2014
    This is version 16 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3