Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

G8RRH7 (G8RRH7_MYCRN) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 15. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Probable DNA ligase HAMAP-Rule MF_00407

EC=6.5.1.1 HAMAP-Rule MF_00407
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP] HAMAP-Rule MF_00407
Gene names
Name:lig HAMAP-Rule MF_00407
Ordered Locus Names:MycrhN_6018 EMBL AEV76480.1
OrganismMycobacterium rhodesiae (strain NBB3) [Complete proteome] [HAMAP] EMBL AEV76480.1
Taxonomic identifier710685 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

Protein attributes

Sequence length515 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP-Rule MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). HAMAP-Rule MF_00407 RuleBase RU000617

Cofactor

Divalent metal cations By similarity. HAMAP-Rule MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family. HAMAP-Rule MF_00407

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site2151N6-AMP-lysine intermediate By similarity HAMAP-Rule MF_00407
Binding site2131ATP By similarity HAMAP-Rule MF_00407
Binding site2201ATP By similarity HAMAP-Rule MF_00407
Binding site2351ATP By similarity HAMAP-Rule MF_00407
Binding site2641ATP By similarity HAMAP-Rule MF_00407
Binding site3041ATP By similarity HAMAP-Rule MF_00407
Binding site3761ATP By similarity HAMAP-Rule MF_00407
Binding site3821ATP By similarity HAMAP-Rule MF_00407

Sequences

Sequence LengthMass (Da)Tools
G8RRH7 [UniParc].

Last modified February 22, 2012. Version 1.
Checksum: 5646D39EF2AB4048

FASTA51554,464
        10         20         30         40         50         60 
MQLLDVAAAS AEVGASSARL KKIARIADLL RRAGEEDDAK LVAVVVSWLS GELPQRQIGV 

        70         80         90        100        110        120 
GWATLRSLPA AAAQASMTVL DVDARLSEIG AVAGKGSQAR RADLVTELFG AATAVEQMFL 

       130        140        150        160        170        180 
RRLLSGELRQ GALIGVMADA VAKAADVPAA AVRRAAMLGG ALPSVAAAAL TAGEAALEQF 

       190        200        210        220        230        240 
TLTVGRPVGP MLAQTATGVA DALERLGGTG AFEAKLDGAR VQIHRSGDAV SIYTRSLDDV 

       250        260        270        280        290        300 
TARLPEIVEA TLALPVTDLI ADAEAIALRP DNRPHRFQVT ASRFGRSVDI AAARSAQPLS 

       310        320        330        340        350        360 
MFVFDLLHLD GTDLLDLPTS ERVAALDEVV PKVHRVDRLI TDDVDAATGF LDATLAAGHE 

       370        380        390        400        410        420 
GVMAKSLTAP YEAGRRGAGW LKVKPVHTLD LVVLAVEWGS GRRTGKLSNI HLGARDPESG 

       430        440        450        460        470        480 
EFIMLGKTFK GMTDAMLDWQ TARFTELADG PTDGYVVKVR PEQVVEIALD GVQTSSRYPG 

       490        500        510 
GMALRFARVL RYRDDKSPAE VDTIDTVRAL HQRGD 

« Hide

References

[1]"Complete sequence of Mycobacterium rhodesiae NBB3."
US DOE Joint Genome Institute
Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Mikhailova N., Gu W., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Mattes T. expand/collapse author list , Holmes A., Rutledge P., Paulsen I., Coleman N., Woyke T.
Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NBB3 EMBL AEV76480.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP003169 Genomic DNA. Translation: AEV76480.1.
RefSeqYP_005003695.1. NC_016604.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEV76480; AEV76480; MycrhN_6018.
GeneID11644927.
KEGGmrh:MycrhN_6018.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01971.

Enzyme and pathway databases

BioCycMRHO710685:GI37-6011-MONOMER.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPMF_00407. DNA_ligase.
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 2 hits.
[Graphical view]
SUPFAMSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG8RRH7_MYCRN
AccessionPrimary (citable) accession number: G8RRH7
Entry history
Integrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: June 11, 2014
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)