Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

G8RRH7

- G8RRH7_MYCRN

UniProt

G8RRH7 - G8RRH7_MYCRN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Probable DNA ligase

Gene

lig

Organism
Mycobacterium rhodesiae (strain NBB3)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Note: Divalent metal cations.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei213 – 2131ATPUniRule annotation
Active sitei215 – 2151N6-AMP-lysine intermediateUniRule annotation
Binding sitei220 – 2201ATPUniRule annotation
Binding sitei235 – 2351ATPUniRule annotation
Binding sitei264 – 2641ATPUniRule annotation
Binding sitei304 – 3041ATPUniRule annotation
Binding sitei376 – 3761ATPUniRule annotation
Binding sitei382 – 3821ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA biosynthetic process Source: InterPro
  4. DNA ligation involved in DNA repair Source: InterPro
  5. DNA recombination Source: UniProtKB-HAMAP
  6. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciMRHO710685:GI37-6011-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:MycrhN_6018Imported
OrganismiMycobacterium rhodesiae (strain NBB3)Imported
Taxonomic identifieri710685 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000005442: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

KOiK01971.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 2 hits.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G8RRH7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQLLDVAAAS AEVGASSARL KKIARIADLL RRAGEEDDAK LVAVVVSWLS
60 70 80 90 100
GELPQRQIGV GWATLRSLPA AAAQASMTVL DVDARLSEIG AVAGKGSQAR
110 120 130 140 150
RADLVTELFG AATAVEQMFL RRLLSGELRQ GALIGVMADA VAKAADVPAA
160 170 180 190 200
AVRRAAMLGG ALPSVAAAAL TAGEAALEQF TLTVGRPVGP MLAQTATGVA
210 220 230 240 250
DALERLGGTG AFEAKLDGAR VQIHRSGDAV SIYTRSLDDV TARLPEIVEA
260 270 280 290 300
TLALPVTDLI ADAEAIALRP DNRPHRFQVT ASRFGRSVDI AAARSAQPLS
310 320 330 340 350
MFVFDLLHLD GTDLLDLPTS ERVAALDEVV PKVHRVDRLI TDDVDAATGF
360 370 380 390 400
LDATLAAGHE GVMAKSLTAP YEAGRRGAGW LKVKPVHTLD LVVLAVEWGS
410 420 430 440 450
GRRTGKLSNI HLGARDPESG EFIMLGKTFK GMTDAMLDWQ TARFTELADG
460 470 480 490 500
PTDGYVVKVR PEQVVEIALD GVQTSSRYPG GMALRFARVL RYRDDKSPAE
510
VDTIDTVRAL HQRGD
Length:515
Mass (Da):54,464
Last modified:February 22, 2012 - v1
Checksum:i5646D39EF2AB4048
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003169 Genomic DNA. Translation: AEV76480.1.
RefSeqiYP_005003695.1. NC_016604.1.

Genome annotation databases

EnsemblBacteriaiAEV76480; AEV76480; MycrhN_6018.
GeneIDi11644927.
KEGGimrh:MycrhN_6018.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003169 Genomic DNA. Translation: AEV76480.1 .
RefSeqi YP_005003695.1. NC_016604.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEV76480 ; AEV76480 ; MycrhN_6018 .
GeneIDi 11644927.
KEGGi mrh:MycrhN_6018.

Phylogenomic databases

KOi K01971.

Enzyme and pathway databases

BioCyci MRHO710685:GI37-6011-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 2 hits.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NBB3Imported.

Entry informationi

Entry nameiG8RRH7_MYCRN
AccessioniPrimary (citable) accession number: G8RRH7
Entry historyi
Integrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: November 26, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3