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G8RRH7

- G8RRH7_MYCRN

UniProt

G8RRH7 - G8RRH7_MYCRN

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Protein
Probable DNA ligase
Gene
lig, MycrhN_6018
Organism
Mycobacterium rhodesiae (strain NBB3)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei213 – 2131ATP By similarityUniRule annotation
Active sitei215 – 2151N6-AMP-lysine intermediate By similarityUniRule annotation
Binding sitei220 – 2201ATP By similarityUniRule annotation
Binding sitei235 – 2351ATP By similarityUniRule annotation
Binding sitei264 – 2641ATP By similarityUniRule annotation
Binding sitei304 – 3041ATP By similarityUniRule annotation
Binding sitei376 – 3761ATP By similarityUniRule annotation
Binding sitei382 – 3821ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. DNA ligation involved in DNA repair Source: InterPro
  2. DNA recombination Source: UniProtKB-HAMAP
  3. DNA replication Source: UniProtKB-HAMAP
  4. cell cycle Source: UniProtKB-KW
  5. cell division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciMRHO710685:GI37-6011-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:MycrhN_6018Imported
OrganismiMycobacterium rhodesiae (strain NBB3)Imported
Taxonomic identifieri710685 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000005442: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

KOiK01971.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 2 hits.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G8RRH7-1 [UniParc]FASTAAdd to Basket

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MQLLDVAAAS AEVGASSARL KKIARIADLL RRAGEEDDAK LVAVVVSWLS    50
GELPQRQIGV GWATLRSLPA AAAQASMTVL DVDARLSEIG AVAGKGSQAR 100
RADLVTELFG AATAVEQMFL RRLLSGELRQ GALIGVMADA VAKAADVPAA 150
AVRRAAMLGG ALPSVAAAAL TAGEAALEQF TLTVGRPVGP MLAQTATGVA 200
DALERLGGTG AFEAKLDGAR VQIHRSGDAV SIYTRSLDDV TARLPEIVEA 250
TLALPVTDLI ADAEAIALRP DNRPHRFQVT ASRFGRSVDI AAARSAQPLS 300
MFVFDLLHLD GTDLLDLPTS ERVAALDEVV PKVHRVDRLI TDDVDAATGF 350
LDATLAAGHE GVMAKSLTAP YEAGRRGAGW LKVKPVHTLD LVVLAVEWGS 400
GRRTGKLSNI HLGARDPESG EFIMLGKTFK GMTDAMLDWQ TARFTELADG 450
PTDGYVVKVR PEQVVEIALD GVQTSSRYPG GMALRFARVL RYRDDKSPAE 500
VDTIDTVRAL HQRGD 515
Length:515
Mass (Da):54,464
Last modified:February 22, 2012 - v1
Checksum:i5646D39EF2AB4048
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003169 Genomic DNA. Translation: AEV76480.1.
RefSeqiYP_005003695.1. NC_016604.1.

Genome annotation databases

EnsemblBacteriaiAEV76480; AEV76480; MycrhN_6018.
GeneIDi11644927.
KEGGimrh:MycrhN_6018.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003169 Genomic DNA. Translation: AEV76480.1 .
RefSeqi YP_005003695.1. NC_016604.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEV76480 ; AEV76480 ; MycrhN_6018 .
GeneIDi 11644927.
KEGGi mrh:MycrhN_6018.

Phylogenomic databases

KOi K01971.

Enzyme and pathway databases

BioCyci MRHO710685:GI37-6011-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 2 hits.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NBB3Imported.

Entry informationi

Entry nameiG8RRH7_MYCRN
AccessioniPrimary (citable) accession number: G8RRH7
Entry historyi
Integrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: June 11, 2014
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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