ID   G8RQL9_MYCRN            Unreviewed;       546 AA.
AC   G8RQL9;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   27-MAR-2024, entry version 60.
DE   SubName: Full=HD-GYP domain-containing protein {ECO:0000313|EMBL:AEV71425.1};
GN   OrderedLocusNames=MycrhN_0794 {ECO:0000313|EMBL:AEV71425.1};
OS   Mycolicibacterium rhodesiae (strain NBB3) (Mycobacterium rhodesiae).
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycolicibacterium.
OX   NCBI_TaxID=710685 {ECO:0000313|EMBL:AEV71425.1, ECO:0000313|Proteomes:UP000005442};
RN   [1] {ECO:0000313|EMBL:AEV71425.1, ECO:0000313|Proteomes:UP000005442}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBB3 {ECO:0000313|EMBL:AEV71425.1,
RC   ECO:0000313|Proteomes:UP000005442};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA   Peters L., Mikhailova N., Gu W., Detter J.C., Han C., Tapia R., Land M.,
RA   Hauser L., Kyrpides N., Ivanova N., Pagani I., Mattes T., Holmes A.,
RA   Rutledge P., Paulsen I., Coleman N., Woyke T.;
RT   "Complete sequence of Mycobacterium rhodesiae NBB3.";
RL   Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CP003169; AEV71425.1; -; Genomic_DNA.
DR   AlphaFoldDB; G8RQL9; -.
DR   STRING; 710685.MycrhN_0794; -.
DR   KEGG; mrh:MycrhN_0794; -.
DR   PATRIC; fig|710685.3.peg.800; -.
DR   eggNOG; COG2197; Bacteria.
DR   eggNOG; COG2206; Bacteria.
DR   HOGENOM; CLU_040286_1_0_11; -.
DR   Proteomes; UP000005442; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   CDD; cd00077; HDc; 1.
DR   CDD; cd06170; LuxR_C_like; 1.
DR   Gene3D; 1.10.3210.10; Hypothetical protein af1432; 2.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR037522; HD_GYP_dom.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR45228; CYCLIC DI-GMP PHOSPHODIESTERASE TM_0186-RELATED; 1.
DR   Pfam; PF00196; GerE; 1.
DR   Pfam; PF13487; HD_5; 2.
DR   PRINTS; PR00038; HTHLUXR.
DR   SMART; SM00471; HDc; 1.
DR   SMART; SM00421; HTH_LUXR; 1.
DR   SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR   SUPFAM; SSF109604; HD-domain/PDEase-like; 2.
DR   PROSITE; PS51832; HD_GYP; 1.
DR   PROSITE; PS00622; HTH_LUXR_1; 1.
DR   PROSITE; PS50043; HTH_LUXR_2; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005442}.
FT   DOMAIN          285..481
FT                   /note="HD-GYP"
FT                   /evidence="ECO:0000259|PROSITE:PS51832"
FT   DOMAIN          476..541
FT                   /note="HTH luxR-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50043"
SQ   SEQUENCE   546 AA;  58720 MW;  815AF2F5E8965608 CRC64;
     MSPVTATATV LTYPADPTVT TAQNRQMSTR AAPPELPTRA EVLAALSVAI DLGLGQPAEH
     MLRSALIATR IADRLSLTAS QRDCIYYATL IMWIGCHADS HEYARWFGDD IAVRRGSYLV
     DWSGLPYQRF LLTNIGRGES LLSRLRTVAT LYANARGHIS ELIHSHCTSA ALLAERIGLS
     SDVQTALRST FERFDGGGLP AGASGEAIPI EMRVAQLADM VEVHQREFGT EGAVAMARSR
     RGGQFDPAVV DAFLADPSGV LAVPSAGDVW ATALQHAPDR ATRLDGQSLD TLLVALGDFV
     DLKCPFTLGH SRAVATLAAD AALIAGLDDD AVTVTRRAAY VHDIGRIGVS NQIWSKSGGL
     TMAEFERMRL HPYLSERILS RVPGLKDVAS VATNHHECLD GSGYPRGLAA RQLTMPDRIL
     ACAVSYQSAL EPRPYREALG PAGAARRLRE RVRDGELDPV AADAVLYASG QAPDRPKTRP
     HGLTAREVEV LRLVAQGASN KEIAAQLVLS EKTVRNHVER TYTKIGVSNR IGASMYALEH
     GLTAEG
//