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G8RN97

- G8RN97_MYCRN

UniProt

G8RN97 - G8RN97_MYCRN

Protein

Alanine racemase

Gene

MycrhN_0591

Organism
Mycobacterium rhodesiae (strain NBB3)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 22 (01 Oct 2014)
      Sequence version 1 (22 Feb 2012)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei49 – 491Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei147 – 1471SubstrateUniRule annotation
    Active sitei278 – 2781Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei326 – 3261Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciMRHO710685:GI37-590-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Ordered Locus Names:MycrhN_0591Imported
    OrganismiMycobacterium rhodesiae (strain NBB3)Imported
    Taxonomic identifieri710685 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000005442: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei49 – 491N6-(pyridoxal phosphate)lysineUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliG8RN97.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    KOiK01775.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G8RN97-1 [UniParc]FASTAAdd to Basket

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    MTMQSTRATT PATAAPPSPE AVVDLDAVAH NVRLLRERAG LAQVMAVVKA    50
    DGYGHGATQT GRAALAAGAA ELGVATVDEA IRLRRDGITA PVLAWLHPPG 100
    TDFAPALEAD VQIAVSSVRQ IGELRDAAER TGRTAKVTVK VDTGLNRNGA 150
    SRAEYTAMLP ELKRALAEEA FTLRGLMSHL VHGDLPDDPL NDLQAQRLRE 200
    MHGQARDQGL RYEVVHLSNS PSLLTRPDLG FDMVRPGIAV YGQTPIPERG 250
    DMGLKPAMTL KCPVALVRPV QAGEGVSYGH TWISDRDTTL ALLPIGYADG 300
    VFRNLSGRID VLINGRLRPA VGRVCMDQLV VDVGSDGDVR EGDDAILFGP 350
    GTDGEPTAQD WAELLGTITY EVVTSPRGRV VRTYRGTPH 389
    Length:389
    Mass (Da):41,558
    Last modified:February 22, 2012 - v1
    Checksum:i0E304CA38F238B81
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003169 Genomic DNA. Translation: AEV71229.1.
    RefSeqiWP_014209049.1. NC_016604.1.
    YP_004998444.1. NC_016604.1.

    Genome annotation databases

    EnsemblBacteriaiAEV71229; AEV71229; MycrhN_0591.
    GeneIDi11641153.
    KEGGimrh:MycrhN_0591.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003169 Genomic DNA. Translation: AEV71229.1 .
    RefSeqi WP_014209049.1. NC_016604.1.
    YP_004998444.1. NC_016604.1.

    3D structure databases

    ProteinModelPortali G8RN97.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEV71229 ; AEV71229 ; MycrhN_0591 .
    GeneIDi 11641153.
    KEGGi mrh:MycrhN_0591.

    Phylogenomic databases

    KOi K01775.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci MRHO710685:GI37-590-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NBB3Imported.

    Entry informationi

    Entry nameiG8RN97_MYCRN
    AccessioniPrimary (citable) accession number: G8RN97
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 22, 2012
    Last sequence update: February 22, 2012
    Last modified: October 1, 2014
    This is version 22 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3