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Protein

Alanine racemase

Gene

MycrhN_0591

Organism
Mycobacterium rhodesiae (strain NBB3)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathway: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (MycrhN_0591)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei49 – 491Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei147 – 1471SubstrateUniRule annotation
Active sitei278 – 2781Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei326 – 3261Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciMRHO710685:GI37-590-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:MycrhN_0591Imported
OrganismiMycobacterium rhodesiae (strain NBB3)Imported
Taxonomic identifieri710685 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
ProteomesiUP000005442 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei49 – 491N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi710685.MycrhN_0591.

Structurei

3D structure databases

ProteinModelPortaliG8RN97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G8RN97-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMQSTRATT PATAAPPSPE AVVDLDAVAH NVRLLRERAG LAQVMAVVKA
60 70 80 90 100
DGYGHGATQT GRAALAAGAA ELGVATVDEA IRLRRDGITA PVLAWLHPPG
110 120 130 140 150
TDFAPALEAD VQIAVSSVRQ IGELRDAAER TGRTAKVTVK VDTGLNRNGA
160 170 180 190 200
SRAEYTAMLP ELKRALAEEA FTLRGLMSHL VHGDLPDDPL NDLQAQRLRE
210 220 230 240 250
MHGQARDQGL RYEVVHLSNS PSLLTRPDLG FDMVRPGIAV YGQTPIPERG
260 270 280 290 300
DMGLKPAMTL KCPVALVRPV QAGEGVSYGH TWISDRDTTL ALLPIGYADG
310 320 330 340 350
VFRNLSGRID VLINGRLRPA VGRVCMDQLV VDVGSDGDVR EGDDAILFGP
360 370 380
GTDGEPTAQD WAELLGTITY EVVTSPRGRV VRTYRGTPH
Length:389
Mass (Da):41,558
Last modified:February 22, 2012 - v1
Checksum:i0E304CA38F238B81
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003169 Genomic DNA. Translation: AEV71229.1.
RefSeqiWP_014209049.1. NC_016604.1.
YP_004998444.1. NC_016604.1.

Genome annotation databases

EnsemblBacteriaiAEV71229; AEV71229; MycrhN_0591.
KEGGimrh:MycrhN_0591.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003169 Genomic DNA. Translation: AEV71229.1.
RefSeqiWP_014209049.1. NC_016604.1.
YP_004998444.1. NC_016604.1.

3D structure databases

ProteinModelPortaliG8RN97.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi710685.MycrhN_0591.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEV71229; AEV71229; MycrhN_0591.
KEGGimrh:MycrhN_0591.

Phylogenomic databases

KOiK01775.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciMRHO710685:GI37-590-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NBB3Imported.

Entry informationi

Entry nameiG8RN97_MYCRN
AccessioniPrimary (citable) accession number: G8RN97
Entry historyi
Integrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: June 24, 2015
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.