Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Alanine racemase

Gene

Oweho_1954

Organism
Owenweeksia hongkongensis (strain DSM 17368 / CIP 108786 / JCM 12287 / NRRL B-23963 / UST20020801)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (Oweho_2301), Alanine racemase (Oweho_1954)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei490Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei589SubstrateUniRule annotation1
Active sitei717Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei766Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotation
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Oweho_1954Imported
OrganismiOwenweeksia hongkongensis (strain DSM 17368 / CIP 108786 / JCM 12287 / NRRL B-23963 / UST20020801)Imported
Taxonomic identifieri926562 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesCryomorphaceaeOwenweeksia
Proteomesi
  • UP000005631 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei490N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi926562.Oweho_1954.

Structurei

3D structure databases

ProteinModelPortaliG8R2E3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini695 – 820Ala_racemase_CInterPro annotationAdd BLAST126

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ4. Bacteria.
COG0770. LUCA.
COG0787. LUCA.
KOiK01775.
OMAiMVKAFAY.
OrthoDBiPOG091H022F.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
3.40.1190.10. 1 hit.
HAMAPiMF_01201. Ala_racemase. 1 hit.
InterProiView protein in InterPro
IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR029066. PLP-binding_barrel.
IPR005863. UDP-N-AcMur_synth.
PfamiView protein in Pfam
PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
PF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
PRINTSiPR00992. ALARACEMASE.
SMARTiView protein in SMART
SM01005. Ala_racemase_C. 1 hit.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
SSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
SSF63418. SSF63418. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
TIGR01143. murF. 1 hit.

Sequencei

Sequence statusi: Complete.

G8R2E3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQLAISKIA ELLNAEFSAL YPSEIVTRIL LDSRQFSSAE GVLFFALRGK
60 70 80 90 100
NHDGHKYIED LVKKGVSHFV VEQMPTQTFD ANFVVVPDSL KALQDLAKHI
110 120 130 140 150
REQSSAAVIA VTGSNGKTVV KEWMGQILQK QFSTCRSPKS YNSQIGVPLS
160 170 180 190 200
VWELEAKNEF AVFESGISEP DEMEKLEKIL QPEIGIFTNI GSAHDANFES
210 220 230 240 250
NSEKIAEKLK LFKHSKQLVY EANGSNLAKQ IEVFTEERGI QLLSWTRENG
260 270 280 290 300
PADLRIEVKI EEAQTVLIGT MDERTHTLQI PFTDAASIQN AIHCWRLGLE
310 320 330 340 350
LSLDEEEMKK SFAKLNPVEM RLQMKAGSNG NIIINDAYNS DMESLRVALH
360 370 380 390 400
YLENQAGNRK KVLIISELQQ SGLASEELFS RMAEVINRFE LDEIIAIGKD
410 420 430 440 450
LKNGAFALNS TAIFYPSTKH FLKNIYSHSF KQSAILLKGA RSFHFEEISS
460 470 480 490 500
ALEEKSHQTV LNIYMNRMVY NLNYFRSKLN GGTRIMAMVK AFSYGSGTYE
510 520 530 540 550
IANLLQFHKV DYLGVAYTDE GVALRKAGIS LPILVLNAEP SSFHDLVEYN
560 570 580 590 600
LEPEVYSFHQ LEMLENALKN YNLSEAFKVH LKVETGMHRL GFVEDQLKDL
610 620 630 640 650
AEKLKSHRHI KVASVFSHLA ASDDPEQRDF TLGQVAKLKQ MTDKLKSDLG
660 670 680 690 700
YSFLRHISNS SGISQYPEAH FDMVRLGVGL YGIGSNVEDK KHLNVVSDLM
710 720 730 740 750
ASVSQVKQLK VGDSVGYGRT FVAEKPTTIA VVSIGYADGF RRSLSNGVGE
760 770 780 790 800
VVISGKRYQV VGRVCMDMVM VDVTGSDVAE GDEVEVFGPT ISVYELAQKM
810 820
DTIPYEVLTG ISSRVKRVYF ME
Length:822
Mass (Da):91,953
Last modified:February 22, 2012 - v1
Checksum:i3EFF30795E369B47
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003156 Genomic DNA. Translation: AEV32933.1.
RefSeqiWP_014202287.1. NC_016599.1.

Genome annotation databases

EnsemblBacteriaiAEV32933; AEV32933; Oweho_1954.
KEGGioho:Oweho_1954.
PATRICifig|926562.3.peg.1961.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiG8R2E3_OWEHD
AccessioniPrimary (citable) accession number: G8R2E3
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: June 7, 2017
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported