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Protein

2,3-bisphosphoglycerate-dependent phosphoglycerate mutase

Gene

gpmA

Organism
Sphaerochaeta pleomorpha (strain ATCC BAA-1885 / DSM 22778 / Grapes)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.UniRule annotation

Catalytic activityi

2-phospho-D-glycerate = 3-phospho-D-glycerate.UniRule annotationSAAS annotation

Pathwayi: glycolysis

This protein is involved in step 3 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk), Phosphoglycerate kinase (SpiGrapes_3133)
  3. Phosphoglycerate mutase (2,3-diphosphoglycerate-independent) (SpiGrapes_1901), 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA)
  4. Enolase (eno)
  5. Pyruvate kinase (SpiGrapes_2243)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei8Tele-phosphohistidine intermediateUniRule annotation1
Binding sitei59SubstrateUniRule annotation1
Active sitei86Proton donor/acceptorUniRule annotation1
Binding sitei97SubstrateUniRule annotation1
Sitei181Transition state stabilizerUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotation
Biological processGluconeogenesisUniRule annotation, GlycolysisUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00109; UER00186.

Names & Taxonomyi

Protein namesi
Recommended name:
2,3-bisphosphoglycerate-dependent phosphoglycerate mutaseUniRule annotation (EC:5.4.2.11UniRule annotation)
Short name:
BPG-dependent PGAMUniRule annotation
Short name:
PGAMUniRule annotation
Short name:
PhosphoglyceromutaseUniRule annotation
Short name:
dPGMUniRule annotation
Gene namesi
Name:gpmAUniRule annotation
Ordered Locus Names:SpiGrapes_2305Imported
OrganismiSphaerochaeta pleomorpha (strain ATCC BAA-1885 / DSM 22778 / Grapes)Imported
Taxonomic identifieri158190 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeSphaerochaeta
Proteomesi
  • UP000005632 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi158190.SpiGrapes_2305.

Structurei

3D structure databases

ProteinModelPortaliG8QSF1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni7 – 14Substrate bindingUniRule annotation8
Regioni20 – 21Substrate bindingUniRule annotation2
Regioni86 – 89Substrate bindingUniRule annotation4
Regioni113 – 114Substrate bindingUniRule annotation2
Regioni182 – 183Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105DKJ. Bacteria.
COG0588. LUCA.
KOiK01834.
OMAiRMLPYWY.
OrthoDBiPOG091H03E2.

Family and domain databases

CDDicd07067. HP_PGM_like. 1 hit.
Gene3Di3.40.50.1240. 1 hit.
HAMAPiMF_01039. PGAM_GpmA. 1 hit.
InterProiView protein in InterPro
IPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
IPR001345. PG/BPGM_mutase_AS.
IPR005952. Phosphogly_mut1.
PANTHERiPTHR11931. PTHR11931. 1 hit.
PfamiView protein in Pfam
PF00300. His_Phos_1. 2 hits.
SMARTiView protein in SMART
SM00855. PGAM. 1 hit.
SUPFAMiSSF53254. SSF53254. 1 hit.
TIGRFAMsiTIGR01258. pgm_1. 1 hit.
PROSITEiView protein in PROSITE
PS00175. PG_MUTASE. 1 hit.

Sequencei

Sequence statusi: Complete.

G8QSF1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLVLLRHGQ SLWNLENRFT GWTDVPLSEA GRLEASEAGR LLKEEGFDFD
60 70 80 90 100
CCYTSYLKRA IQTLDLVLEQ MDRQWLPVVK SWKLNERHYG ALQGLNKAET
110 120 130 140 150
AVKYGNEQVL LWRRSFSVQP PSLSINDERN PALQNQYRGI DKNVLPFTES
160 170 180 190 200
LKDTIARTIP YFEEEIKPRM LKGERILIVA HGNSLRALVM YFEHLSEDEI
210 220 230 240
MQVNIPTGIP LIYTFSKDFS VKKKYYLGDS GEIAEKMRQV SDQGKATKA
Length:249
Mass (Da):28,720
Last modified:February 22, 2012 - v1
Checksum:i180A3A5A5EDF27B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003155 Genomic DNA. Translation: AEV30081.1.
RefSeqiWP_014270922.1. NC_016633.1.

Genome annotation databases

EnsemblBacteriaiAEV30081; AEV30081; SpiGrapes_2305.
KEGGisgp:SpiGrapes_2305.

Similar proteinsi

Entry informationi

Entry nameiG8QSF1_SPHPG
AccessioniPrimary (citable) accession number: G8QSF1
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: September 27, 2017
This is version 40 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported