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G8QQM9

- G8QQM9_SPHPG

UniProt

G8QQM9 - G8QQM9_SPHPG

Protein

D-alanine--D-alanine ligase

Gene

ddl

Organism
Sphaerochaeta pleomorpha (strain ATCC BAA-1885 / DSM 22778 / Grapes)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 19 (01 Oct 2014)
      Sequence version 1 (22 Feb 2012)
      Previous versions | rss
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    Functioni

    Cell wall formation.UniRule annotationSAAS annotation

    Catalytic activityi

    ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi320 – 3201Magnesium or manganese 1UniRule annotation
    Metal bindingi332 – 3321Magnesium or manganese 1UniRule annotation
    Metal bindingi332 – 3321Magnesium or manganese 2UniRule annotation
    Metal bindingi334 – 3341Magnesium or manganese 2UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi184 – 24158ATPUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. D-alanine-D-alanine ligase activity Source: UniProtKB-HAMAP
    3. magnesium ion binding Source: UniProtKB-HAMAP
    4. manganese ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
    2. regulation of cell shape Source: UniProtKB-KW

    Keywords - Molecular functioni

    LigaseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, ManganeseUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSPLE158190:GHFO-3215-MONOMER.
    UniPathwayiUPA00219.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    D-alanine--D-alanine ligaseUniRule annotation (EC:6.3.2.4UniRule annotation)
    Alternative name(s):
    D-Ala-D-Ala ligaseUniRule annotation
    D-alanylalanine synthetaseUniRule annotation
    Gene namesi
    Name:ddlUniRule annotation
    Ordered Locus Names:SpiGrapes_3214Imported
    OrganismiSphaerochaeta pleomorpha (strain ATCC BAA-1885 / DSM 22778 / Grapes)Imported
    Taxonomic identifieri158190 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeSphaerochaeta
    ProteomesiUP000005632: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini127 – 365239ATP-graspUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the D-alanine--D-alanine ligase family.UniRule annotation
    Contains 1 ATP-grasp domain.UniRule annotation
    Contains ATP-grasp domain.SAAS annotation

    Phylogenomic databases

    KOiK01921.
    OMAiGIATPRF.

    Family and domain databases

    Gene3Di3.30.1490.20. 1 hit.
    3.30.470.20. 2 hits.
    3.40.50.20. 1 hit.
    HAMAPiMF_00047. Dala_Dala_lig.
    InterProiIPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR000291. D-Ala_lig_Van_CS.
    IPR005905. D_ala_D_ala.
    IPR011095. Dala_Dala_lig_C.
    IPR011127. Dala_Dala_lig_N.
    IPR016185. PreATP-grasp_dom.
    [Graphical view]
    PANTHERiPTHR23132. PTHR23132. 1 hit.
    PfamiPF07478. Dala_Dala_lig_C. 1 hit.
    PF01820. Dala_Dala_lig_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF52440. SSF52440. 1 hit.
    PROSITEiPS50975. ATP_GRASP. 1 hit.
    PS00843. DALA_DALA_LIGASE_1. 1 hit.
    PS00844. DALA_DALA_LIGASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G8QQM9-1 [UniParc]FASTAAdd to Basket

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    MHVALLYGGR SSEHNVSIKS AQNIYTILKK LGHAVLPIGI SLSGTFHLQE    50
    DKPIQETIDQ RQNVTVLPGL GFSCNNNLLP IEVAFPVTHG MGGEDGNLQG 100
    LCFLAQIPLC GCDTVSSALG MHKELAQQLF ASAGIPTVPT LSLNANAIAW 150
    LKEVEGASLP AFLGEHFFCS TCTTRIEIAL PRILKQLGPS LLVKPENSGS 200
    SVGVTALKTP TGETLLSAIA YAAKFSECVL LQRLIEPMVE IECAVLTTQD 250
    KGLLVAGPGL VIDPAKQNAG FLTYAHKYGQ IDTAHMQIPS TLDGETEKTI 300
    RDYAKKAFLS IKGDGYARVD FFFSDGLLYI NEINTLPGMT ATSHYPVLMQ 350
    SCGYSLEQVV QTLLDHTILR AQEEKGRTYV PPGI 384
    Length:384
    Mass (Da):41,340
    Last modified:February 22, 2012 - v1
    Checksum:i816779E2EAE6FF93
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003155 Genomic DNA. Translation: AEV30959.1.
    RefSeqiYP_005063969.1. NC_016633.1.

    Genome annotation databases

    EnsemblBacteriaiAEV30959; AEV30959; SpiGrapes_3214.
    GeneIDi11577809.
    KEGGisgp:SpiGrapes_3214.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003155 Genomic DNA. Translation: AEV30959.1 .
    RefSeqi YP_005063969.1. NC_016633.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEV30959 ; AEV30959 ; SpiGrapes_3214 .
    GeneIDi 11577809.
    KEGGi sgp:SpiGrapes_3214.

    Phylogenomic databases

    KOi K01921.
    OMAi GIATPRF.

    Enzyme and pathway databases

    UniPathwayi UPA00219 .
    BioCyci SPLE158190:GHFO-3215-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1490.20. 1 hit.
    3.30.470.20. 2 hits.
    3.40.50.20. 1 hit.
    HAMAPi MF_00047. Dala_Dala_lig.
    InterProi IPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR000291. D-Ala_lig_Van_CS.
    IPR005905. D_ala_D_ala.
    IPR011095. Dala_Dala_lig_C.
    IPR011127. Dala_Dala_lig_N.
    IPR016185. PreATP-grasp_dom.
    [Graphical view ]
    PANTHERi PTHR23132. PTHR23132. 1 hit.
    Pfami PF07478. Dala_Dala_lig_C. 1 hit.
    PF01820. Dala_Dala_lig_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52440. SSF52440. 1 hit.
    PROSITEi PS50975. ATP_GRASP. 1 hit.
    PS00843. DALA_DALA_LIGASE_1. 1 hit.
    PS00844. DALA_DALA_LIGASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-1885 / DSM 22778 / GrapesImported.

    Entry informationi

    Entry nameiG8QQM9_SPHPG
    AccessioniPrimary (citable) accession number: G8QQM9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 22, 2012
    Last sequence update: February 22, 2012
    Last modified: October 1, 2014
    This is version 19 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3