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G8QQM9 (G8QQM9_SPHPG) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 16. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:SpiGrapes_3214 EMBL AEV30959.1
OrganismSphaerochaeta pleomorpha (strain ATCC BAA-1885 / DSM 22778 / Grapes) [Complete proteome] [HAMAP] EMBL AEV30959.1
Taxonomic identifier158190 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeSphaerochaeta

Protein attributes

Sequence length384 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain127 – 365239ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding184 – 24158ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding3201Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3321Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3321Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3341Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
G8QQM9 [UniParc].

Last modified February 22, 2012. Version 1.
Checksum: 816779E2EAE6FF93

FASTA38441,340
        10         20         30         40         50         60 
MHVALLYGGR SSEHNVSIKS AQNIYTILKK LGHAVLPIGI SLSGTFHLQE DKPIQETIDQ 

        70         80         90        100        110        120 
RQNVTVLPGL GFSCNNNLLP IEVAFPVTHG MGGEDGNLQG LCFLAQIPLC GCDTVSSALG 

       130        140        150        160        170        180 
MHKELAQQLF ASAGIPTVPT LSLNANAIAW LKEVEGASLP AFLGEHFFCS TCTTRIEIAL 

       190        200        210        220        230        240 
PRILKQLGPS LLVKPENSGS SVGVTALKTP TGETLLSAIA YAAKFSECVL LQRLIEPMVE 

       250        260        270        280        290        300 
IECAVLTTQD KGLLVAGPGL VIDPAKQNAG FLTYAHKYGQ IDTAHMQIPS TLDGETEKTI 

       310        320        330        340        350        360 
RDYAKKAFLS IKGDGYARVD FFFSDGLLYI NEINTLPGMT ATSHYPVLMQ SCGYSLEQVV 

       370        380 
QTLLDHTILR AQEEKGRTYV PPGI 

« Hide

References

[1]"Complete sequence of Spirochaeta sp. grapes."
US DOE Joint Genome Institute
Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Ovchinnikova G., Munk A.C., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Ritalahtilisa K., Loeffler F., Woyke T.
Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-1885 / DSM 22778 / Grapes.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP003155 Genomic DNA. Translation: AEV30959.1.
RefSeqYP_005063969.1. NC_016633.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEV30959; AEV30959; SpiGrapes_3214.
GeneID11577809.
KEGGsgp:SpiGrapes_3214.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.
OMAIPYVGCD.

Enzyme and pathway databases

BioCycSPLE158190:GHFO-3215-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG8QQM9_SPHPG
AccessionPrimary (citable) accession number: G8QQM9
Entry history
Integrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: February 19, 2014
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)