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G8QQM9

- G8QQM9_SPHPG

UniProt

G8QQM9 - G8QQM9_SPHPG

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Protein
D-alanine--D-alanine ligase
Gene
ddl, SpiGrapes_3214
Organism
Sphaerochaeta pleomorpha (strain ATCC BAA-1885 / DSM 22778 / Grapes)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cell wall formation By similarity.UniRule annotationSAAS annotations

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotationSAAS annotations

Cofactori

Binds 2 magnesium or manganese ions per subunit By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi320 – 3201Magnesium or manganese 1 By similarityUniRule annotation
Metal bindingi332 – 3321Magnesium or manganese 1 By similarityUniRule annotation
Metal bindingi332 – 3321Magnesium or manganese 2 By similarityUniRule annotation
Metal bindingi334 – 3341Magnesium or manganese 2 By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi184 – 24158ATP By similarityUniRule annotation
Add
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. D-alanine-D-alanine ligase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. manganese ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  2. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotations, Peptidoglycan synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, MagnesiumUniRule annotationSAAS annotations, ManganeseUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding

Enzyme and pathway databases

BioCyciSPLE158190:GHFO-3215-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotation (EC:6.3.2.4UniRule annotation)
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene namesi
Name:ddlUniRule annotation
Ordered Locus Names:SpiGrapes_3214Imported
OrganismiSphaerochaeta pleomorpha (strain ATCC BAA-1885 / DSM 22778 / Grapes)Imported
Taxonomic identifieri158190 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeSphaerochaeta
ProteomesiUP000005632: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini127 – 365239ATP-grasp By similarityUniRule annotation
Add
BLAST

Sequence similaritiesi

Contains 1 ATP-grasp domain.UniRule annotation
Contains ATP-grasp domain.SAAS annotations

Phylogenomic databases

KOiK01921.
OMAiGIATPRF.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPiMF_00047. Dala_Dala_lig.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G8QQM9-1 [UniParc]FASTAAdd to Basket

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MHVALLYGGR SSEHNVSIKS AQNIYTILKK LGHAVLPIGI SLSGTFHLQE    50
DKPIQETIDQ RQNVTVLPGL GFSCNNNLLP IEVAFPVTHG MGGEDGNLQG 100
LCFLAQIPLC GCDTVSSALG MHKELAQQLF ASAGIPTVPT LSLNANAIAW 150
LKEVEGASLP AFLGEHFFCS TCTTRIEIAL PRILKQLGPS LLVKPENSGS 200
SVGVTALKTP TGETLLSAIA YAAKFSECVL LQRLIEPMVE IECAVLTTQD 250
KGLLVAGPGL VIDPAKQNAG FLTYAHKYGQ IDTAHMQIPS TLDGETEKTI 300
RDYAKKAFLS IKGDGYARVD FFFSDGLLYI NEINTLPGMT ATSHYPVLMQ 350
SCGYSLEQVV QTLLDHTILR AQEEKGRTYV PPGI 384
Length:384
Mass (Da):41,340
Last modified:February 22, 2012 - v1
Checksum:i816779E2EAE6FF93
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003155 Genomic DNA. Translation: AEV30959.1.
RefSeqiYP_005063969.1. NC_016633.1.

Genome annotation databases

EnsemblBacteriaiAEV30959; AEV30959; SpiGrapes_3214.
GeneIDi11577809.
KEGGisgp:SpiGrapes_3214.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003155 Genomic DNA. Translation: AEV30959.1 .
RefSeqi YP_005063969.1. NC_016633.1.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEV30959 ; AEV30959 ; SpiGrapes_3214 .
GeneIDi 11577809.
KEGGi sgp:SpiGrapes_3214.

Phylogenomic databases

KOi K01921.
OMAi GIATPRF.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci SPLE158190:GHFO-3215-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPi MF_00047. Dala_Dala_lig.
InterProi IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view ]
PANTHERi PTHR23132. PTHR23132. 1 hit.
Pfami PF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view ]
SUPFAMi SSF52440. SSF52440. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1885 / DSM 22778 / Grapes.

Entry informationi

Entry nameiG8QQM9_SPHPG
AccessioniPrimary (citable) accession number: G8QQM9
Entry historyi
Integrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: June 11, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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