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Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

Dsui_1577

Organism
Dechlorosoma suillum (strain ATCC BAA-33 / DSM 13638 / PS) (Azospira oryzae)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

Catalytic activityi

Acetyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-acetyldihydrolipoyl)lysine.UniRule annotation

Cofactori

(R)-lipoateUniRule annotationNote: Binds 2 lipoyl cofactors covalently.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseUniRule annotation, Transferase
Biological processGlycolysisUniRule annotation
LigandPyruvateImported

Enzyme and pathway databases

BioCyciDSUI640081:G12WK-1564-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
Gene namesi
Ordered Locus Names:Dsui_1577Imported
OrganismiDechlorosoma suillum (strain ATCC BAA-33 / DSM 13638 / PS) (Azospira oryzae)Imported
Taxonomic identifieri640081 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeAzospira
Proteomesi
  • UP000005633 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Interactioni

Subunit structurei

Forms a 24-polypeptide structural core with octahedral symmetry.UniRule annotation

Protein-protein interaction databases

STRINGi640081.Dsui_1577.

Structurei

3D structure databases

ProteinModelPortaliG8QPQ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 78Lipoyl-bindingInterPro annotationAdd BLAST75
Domaini120 – 194Lipoyl-bindingInterPro annotationAdd BLAST75

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation

Keywords - Domaini

LipoylUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4107QSN. Bacteria.
COG0508. LUCA.
KOiK00627.
OMAiTMEFESF.
OrthoDBiPOG091H05OF.

Family and domain databases

Gene3Di4.10.320.10. 1 hit.
InterProiView protein in InterPro
IPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR006256. AcTrfase_Pyrv_DH_cplx.
IPR000089. Biotin_lipoyl.
IPR004167. E3-bd.
IPR011053. Single_hybrid_motif.
PANTHERiPTHR43178:SF4. PTHR43178:SF4. 1 hit.
PfamiView protein in Pfam
PF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 2 hits.
PF02817. E3_binding. 1 hit.
SUPFAMiSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 2 hits.
TIGRFAMsiTIGR01348. PDHac_trf_long. 1 hit.
PROSITEiView protein in PROSITE
PS50968. BIOTINYL_LIPOYL. 2 hits.
PS00189. LIPOYL. 2 hits.

Sequencei

Sequence statusi: Complete.

G8QPQ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQTIEVKVP DIGDFKDVPV IEIFVKPGDT VKVEDPLCSL ESDKATMDVP
60 70 80 90 100
SSAAGVVKEV KIKVGDKVAE GSVVVILESA ASGAAAAAPA PQAAAPAPVA
110 120 130 140 150
AAPAAPAPVA AAPAPAASGP VEVKVPDIGD FKDVPVIEVF VKVGDTVKQE
160 170 180 190 200
DALCSLESDK ATMDVPSSAA GVVKEVRVKV GDKVSEGSVV VVLEGAAGAV
210 220 230 240 250
AAVAAAPAAA APAPAAPAVI PPELDGPAPT KPFTPAPAAA PYGLALGGKV
260 270 280 290 300
HASPSVRAFA RELGVDLSKV TATGPKSRIQ AEDVKAYIKG VMSGQTVAPT
310 320 330 340 350
QVGGGGITGG GSLDLLPWPK VDFAKFGPIE AKPLSRIKKI SGANLARNWV
360 370 380 390 400
MIPAVTYHED ADITDLEAFR VQLNKENEKS GQKLTMLAFI IKACVKVLQQ
410 420 430 440 450
FPELNTSLDG DNLVYKKYYH IGFAADTPNG LVVPVLKDAD KKGVLEIAKE
460 470 480 490 500
TGELAKLARD GKLKPADMQG ATFTISSVGG IGGTAFSPIV NAPEVAILGV
510 520 530 540 550
SKSSMKPVWN GKEFVPRLIV PLSLSADHRV IDGALATRFN AELAKLLADF

RRVML
Length:555
Mass (Da):57,010
Last modified:February 22, 2012 - v1
Checksum:i37BFFFD535968CF9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003153 Genomic DNA. Translation: AEV25966.1.
RefSeqiWP_014236665.1. NC_016616.1.

Genome annotation databases

EnsemblBacteriaiAEV25966; AEV25966; Dsui_1577.
KEGGidsu:Dsui_1577.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiG8QPQ7_DECSP
AccessioniPrimary (citable) accession number: G8QPQ7
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: June 7, 2017
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported