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Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Pseudomonas fluorescens F113
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciPFLU1114970:GJXA-2189-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:icdImported
ORF Names:PSF113_2169Imported
OrganismiPseudomonas fluorescens F113Imported
Taxonomic identifieri1114970 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000005437: Chromosome

PTM / Processingi

Proteomic databases

PRIDEiG8Q8P2.

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G8Q8P2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGYQKIQVPA VGDKITVNAD HSLNVPDNPI IPFIEGDGIG VDISPVMIKV
60 70 80 90 100
VDAAVQKAYG GKRKISWMEV YAGEKATQVY DQDTWLPQET LDAVKDYVVS
110 120 130 140 150
IKGPLTTPVG GGIRSLNVAL RQQLDLYVCL RPVRWFEGVP SPVKKPGDVD
160 170 180 190 200
MTIFRENSED IYAGIEWKAG SAEATKVIKF LKEEMGVTKI RFDEDCGIGI
210 220 230 240 250
KPVSKQGTQR LARKALQYVV DNDRESLTIV HKGNIMKFTE GAFKEWAYEV
260 270 280 290 300
AAEEFGATLL DGGPWMQFKN PKTGKNVVVK DAIADAMLQQ ILLRPAEYDV
310 320 330 340 350
IATLNLNGDY LSDALAAEVG GIGIAPGANL SDTVAMFEAT HGTAPKYAGK
360 370 380 390 400
DQVNPGSLIL SAEMMLRHMG WTEAADLIIK GTNGAISAKT VTYDFERLME
410
GAKLVSSSGF GDALISHM
Length:418
Mass (Da):45,404
Last modified:February 22, 2012 - v1
Checksum:i39EA8672D4FFA9CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003150 Genomic DNA. Translation: AEV62180.1.
RefSeqiYP_005207575.1. NC_016830.1.

Genome annotation databases

EnsemblBacteriaiAEV62180; AEV62180; PSF113_2169.
GeneIDi11830262.
KEGGipfe:PSF113_2169.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003150 Genomic DNA. Translation: AEV62180.1.
RefSeqiYP_005207575.1. NC_016830.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiG8Q8P2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEV62180; AEV62180; PSF113_2169.
GeneIDi11830262.
KEGGipfe:PSF113_2169.

Phylogenomic databases

KOiK00031.

Enzyme and pathway databases

BioCyciPFLU1114970:GJXA-2189-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: F113Imported.

Entry informationi

Entry nameiG8Q8P2_PSEFL
AccessioniPrimary (citable) accession number: G8Q8P2
Entry historyi
Integrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: February 4, 2015
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.