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Protein

Alanine racemase

Gene

dadB

Organism
Pseudovibrio sp. (strain FO-BEG1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei51 – 511Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei149 – 1491SubstrateUniRule annotation
Active sitei271 – 2711Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei325 – 3251Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciPSP911045:GJTQ-2740-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:dadBImported
Ordered Locus Names:PSE_2712Imported
OrganismiPseudovibrio sp. (strain FO-BEG1)Imported
Taxonomic identifieri911045 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaePseudovibrio
ProteomesiUP000005634 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei51 – 511N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliG8PQX4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.
OMAiDAGTISY.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.

Sequencei

Sequence statusi: Complete.

G8PQX4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHSAAPTSD RPAVSAGGAA KLTIDLTALR SNWCYLNGKV GDGCTCAVVL
60 70 80 90 100
KANGYGTGAA EVGKTLYHAG ARVFFVALPE EGIELRKELP HAEIYVLNGL
110 120 130 140 150
FRDREKFYYD FDLKPVLNSL EEVAEWSSFA QSLQEELPAA LHFDTGMHRL
160 170 180 190 200
GMSIGDALQI GESAHLLKGI RIDLVMSHLA CADTPGHGLN EKQLNRFQRV
210 220 230 240 250
CELFPEARKS LSNSAGIFLG DDYHFDMVRP GIALYGGNPV PDETNPMLPV
260 270 280 290 300
AHVQAEIISL REVPHGDPVG YGASRVTPRK SRIATINAGY ADGLHRLVGS
310 320 330 340 350
SDDQPNGARV YIGGHFAPIF GRVSMDMIAV DVTDIPEEHL SRGAPVEIMG
360 370 380
AHVNVDELAE FAQTIPYELL CSLGARYTRH YKR
Length:383
Mass (Da):41,680
Last modified:February 22, 2012 - v1
Checksum:i6F91441482FBBAE2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003147 Genomic DNA. Translation: AEV37220.1.
RefSeqiWP_014285320.1. NC_016642.1.
YP_005081242.1. NC_016642.1.

Genome annotation databases

EnsemblBacteriaiAEV37220; AEV37220; PSE_2712.
KEGGipsf:PSE_2712.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003147 Genomic DNA. Translation: AEV37220.1.
RefSeqiWP_014285320.1. NC_016642.1.
YP_005081242.1. NC_016642.1.

3D structure databases

ProteinModelPortaliG8PQX4.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEV37220; AEV37220; PSE_2712.
KEGGipsf:PSE_2712.

Phylogenomic databases

KOiK01775.
OMAiDAGTISY.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciPSP911045:GJTQ-2740-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The genus Pseudovibrio contains metabolically versatile and symbiotically interacting bacteria."
    Bondarev V., Richter M., Piel J., Schwedt A., Schulz-Vogt H.N.
    Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FO-BEG1Imported.

Entry informationi

Entry nameiG8PQX4_PSEUV
AccessioniPrimary (citable) accession number: G8PQX4
Entry historyi
Integrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: April 1, 2015
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.