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Protein

Malate dehydrogenase

Gene

mdh

Organism
Pseudovibrio sp. (strain FO-BEG1)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotationSAAS annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei34NADUniRule annotation1
Binding sitei83SubstrateUniRule annotation1
Binding sitei89SubstrateUniRule annotation1
Binding sitei96NADUniRule annotation1
Binding sitei121SubstrateUniRule annotation1
Binding sitei152SubstrateUniRule annotation1
Active sitei176Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 15NADUniRule annotation6
Nucleotide bindingi119 – 121NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotationImported
Biological processTricarboxylic acid cycleUniRule annotationSAAS annotation
LigandNADUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotationImported
Ordered Locus Names:PSE_0614Imported
OrganismiPseudovibrio sp. (strain FO-BEG1)Imported
Taxonomic identifieri911045 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaePseudovibrio
Proteomesi
  • UP000005634 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi911045.PSE_0614

Structurei

3D structure databases

ProteinModelPortaliG8PMX1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 143Ldh_1_NInterPro annotationAdd BLAST139
Domaini147 – 305Ldh_1_CInterPro annotationAdd BLAST159

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C80 Bacteria
COG0039 LUCA
KOiK00024
OMAiMDLMQTA
OrthoDBiPOG091H02N6

Family and domain databases

CDDicd01339 LDH-like_MDH, 1 hit
Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00487 Malate_dehydrog_3, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR011275 Malate_DH_type3
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01763 MalateDH_bact, 1 hit

Sequencei

Sequence statusi: Complete.

G8PMX1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARNKIALIG SGQIGGTLAH LAGLKELGDI VLFDIAEGMP QGKALDLAES
60 70 80 90 100
SPVDGFDSGL SGTNTYEGIE GADVVIVTAG VPRKPGMSRD DLLEINLKVM
110 120 130 140 150
EQVGAGIKKY APDAFVICIT NPLDAMVWAL QKFSGLPANK VVGMAGVLDS
160 170 180 190 200
ARFRYFLAEE FNVSVEDVTA FVLGGHGDTM VPLTRYSTVA GVPLTDLVKM
210 220 230 240 250
GWLTAERLEE IVQRTRDGGA EIVGLLKTGS AFYAPAASAI QMAESYLKDK
260 270 280 290 300
KRVLPCAAHL DGQYGQKDMY VGVPTVIGAN GIERIIEIDL NSDEKAMFDK
310 320
SVASVNGLVD ACKKIQPALA
Length:320
Mass (Da):33,893
Last modified:February 22, 2012 - v1
Checksum:iCC3B2B5B88936B7A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003147 Genomic DNA Translation: AEV35126.1
RefSeqiWP_008548788.1, NC_016642.1

Genome annotation databases

EnsemblBacteriaiAEV35126; AEV35126; PSE_0614
KEGGipsf:PSE_0614

Similar proteinsi

Entry informationi

Entry nameiG8PMX1_PSEUV
AccessioniPrimary (citable) accession number: G8PMX1
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: March 28, 2018
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health