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Protein

Xylose isomerase

Gene

xylA

Organism
Lactococcus lactis subsp. cremoris A76
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-xylopyranose = D-xylulose.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei101 – 1011UniRule annotation
Active sitei104 – 1041UniRule annotation
Metal bindingi232 – 2321Magnesium 1UniRule annotation
Metal bindingi268 – 2681Magnesium 1UniRule annotation
Metal bindingi268 – 2681Magnesium 2UniRule annotation
Metal bindingi271 – 2711Magnesium 2UniRule annotation
Metal bindingi296 – 2961Magnesium 1UniRule annotation
Metal bindingi307 – 3071Magnesium 2UniRule annotation
Metal bindingi309 – 3091Magnesium 2UniRule annotation
Metal bindingi339 – 3391Magnesium 1UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. xylose isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-xylose metabolic process Source: UniProtKB-HAMAP
  2. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotation

Keywords - Biological processi

Carbohydrate metabolism, Pentose shuntUniRule annotation, Xylose metabolismUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciLLAC1104322:GLFE-1032-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Xylose isomeraseUniRule annotation (EC:5.3.1.5UniRule annotation)
Gene namesi
Name:xylAUniRule annotation
ORF Names:llh_5060Imported
OrganismiLactococcus lactis subsp. cremoris A76Imported
Taxonomic identifieri1104322 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
ProteomesiUP000007114: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliG8P8X4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the xylose isomerase family.UniRule annotation

Phylogenomic databases

KOiK01805.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G8P8X4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYFNDIAPI KYEGTKTKNM FAFRHYNPEE VVAGKTMEEQ LHFALAFWHT
60 70 80 90 100
ITMDGADPFG SATMERPWDL EGGSELDRAH RRVDAFFEIA EKLGVKYYCF
110 120 130 140 150
HDIDIAPTGN SLKEFYANLD EITDHLLEKQ KETGIKLLWN TANMFSNPRY
160 170 180 190 200
MNGVSTSNRA EVFAYGAAQV KKGLELSKKL GGENYVFWGG REGYESLLNT
210 220 230 240 250
DMGLEMDHMA KFFHLAIDYA KSINHLPIFL IELKPKEPMT HQYDFDAATA
260 270 280 290 300
LAFLQKYDLD KYFKLNIETN HAWLAGHTFE HELNTARTFG ALGSIDANQG
310 320 330 340 350
NYLLGWDTDE FPTLVIDITL AMHQILLNGG LGKGGINFDA KVRRTSFKAE
360 370 380 390 400
DLILAHIAGM DTYARALKGA AAIIEDKFLS DIVEERYSSY KKTEVGQSIE
410 420 430
NGTATFESLA AYALEHGDDI ELDSNHLEYI KSVLNDYLV
Length:439
Mass (Da):49,626
Last modified:February 22, 2012 - v1
Checksum:iF686999CAA26EBF4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003132 Genomic DNA. Translation: AEU40188.1.
RefSeqiWP_014572399.1. NC_017492.1.
YP_005875611.1. NC_017492.1.

Genome annotation databases

EnsemblBacteriaiAEU40188; AEU40188; llh_5060.
GeneIDi12484588.
KEGGillr:llh_5060.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003132 Genomic DNA. Translation: AEU40188.1.
RefSeqiWP_014572399.1. NC_017492.1.
YP_005875611.1. NC_017492.1.

3D structure databases

ProteinModelPortaliG8P8X4.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEU40188; AEU40188; llh_5060.
GeneIDi12484588.
KEGGillr:llh_5060.

Phylogenomic databases

KOiK01805.

Enzyme and pathway databases

BioCyciLLAC1104322:GLFE-1032-MONOMER.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete Genome Sequence of Lactococcus lactis subsp. cremoris A76."
    Bolotin A., Quinquis B., Ehrlich S.D., Sorokin A.
    Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: A76Imported.

Entry informationi

Entry nameiG8P8X4_LACLC
AccessioniPrimary (citable) accession number: G8P8X4
Entry historyi
Integrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: March 4, 2015
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.