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Protein

Isocitrate dehydrogenase [NADP]

Gene

AciX8_1286

Organism
Granulicella mallensis (strain ATCC BAA-1857 / DSM 23137 / MP5ACTX8)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciGMAL682795:GHBV-1303-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:AciX8_1286Imported
OrganismiGranulicella mallensis (strain ATCC BAA-1857 / DSM 23137 / MP5ACTX8)Imported
Taxonomic identifieri682795 [NCBI]
Taxonomic lineageiBacteriaAcidobacteriaAcidobacterialesAcidobacteriaceaeGranulicella
ProteomesiUP000007113 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi682795.AciX8_1286.

Structurei

3D structure databases

ProteinModelPortaliG8NYX7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 2 hits.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G8NYX7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTSYNDIPV PSDGQAIEYA NGKYTVPDHP IIPFIEGDGT GRDIWKASQR
60 70 80 90 100
VFDAAVEKAY GGKRSVKWFE VLAGEKSYRK TQNWLPDDTV KATVDFRVSI
110 120 130 140 150
KGPLTTPVGG GIRSLNVALR QLMDLYQCVR PVKYYSGVPS PVKSPEKLDV
160 170 180 190 200
VIFRENTEDI YAGIEFREGT PEAAKFIAFV NDEMLKGTKK KVRLDSGVGV
210 220 230 240 250
KPISITGSKR LVRAAIQYAI DHQRKTVTLV HKGNIQKFTE GAFREWGYEV
260 270 280 290 300
ATQEFRAHTV TERESWILGN LEQNPKLTPE ENAALVEPGI EFASKEFGES
310 320 330 340 350
IVQEVRDVVA SIGATHGNGQ WKNKILVNDR IADSIFQQII IRPSDYSVLA
360 370 380 390 400
TTNLNGDYIS DAAAAQVGGL GIAPGANIGD GYAVFEATHG TAPKYADKDV
410 420 430 440 450
INPGSVMLSG VMMFDFLGWS EAARLIESSM EKTIQQKFVT YDFERQMQGA
460
TKAKTSEFAS RMIENMG
Length:467
Mass (Da):51,555
Last modified:February 22, 2012 - v1
Checksum:i1639DD4FA8D86935
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003130 Genomic DNA. Translation: AEU35629.1.
RefSeqiWP_014264509.1. NC_016631.1.

Genome annotation databases

EnsemblBacteriaiAEU35629; AEU35629; AciX8_1286.
KEGGigma:AciX8_1286.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003130 Genomic DNA. Translation: AEU35629.1.
RefSeqiWP_014264509.1. NC_016631.1.

3D structure databases

ProteinModelPortaliG8NYX7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi682795.AciX8_1286.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEU35629; AEU35629; AciX8_1286.
KEGGigma:AciX8_1286.

Phylogenomic databases

KOiK00031.

Enzyme and pathway databases

BioCyciGMAL682795:GHBV-1303-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 2 hits.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of Granulicella mallensis MP5ACTX8."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Lu M., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Mikhailova N., Pagani I., Rawat S.
    , Mannisto M., Haggblom M., Woyke T.
    Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1857 / DSM 23137 / MP5ACTX8Imported.

Entry informationi

Entry nameiG8NYX7_GRAMM
AccessioniPrimary (citable) accession number: G8NYX7
Entry historyi
Integrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: July 22, 2015
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.