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G8NYX7

- G8NYX7_GRAMM

UniProt

G8NYX7 - G8NYX7_GRAMM

Protein

Isocitrate dehydrogenase [NADP]

Gene

AciX8_1286

Organism
Granulicella mallensis (strain ATCC BAA-1857 / DSM 23137 / MP5ACTX8)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 12 (01 Oct 2014)
      Sequence version 1 (22 Feb 2012)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation
    Binds 1 magnesium or manganese ion per subunit By similarity.

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciGMAL682795:GHBV-1303-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Ordered Locus Names:AciX8_1286Imported
    OrganismiGranulicella mallensis (strain ATCC BAA-1857 / DSM 23137 / MP5ACTX8)Imported
    Taxonomic identifieri682795 [NCBI]
    Taxonomic lineageiBacteriaAcidobacteriaAcidobacterialesAcidobacteriaceaeGranulicella
    ProteomesiUP000007113: Chromosome

    Structurei

    3D structure databases

    ProteinModelPortaliG8NYX7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    KOiK00031.

    Family and domain databases

    Gene3Di3.40.718.10. 2 hits.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G8NYX7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQTSYNDIPV PSDGQAIEYA NGKYTVPDHP IIPFIEGDGT GRDIWKASQR    50
    VFDAAVEKAY GGKRSVKWFE VLAGEKSYRK TQNWLPDDTV KATVDFRVSI 100
    KGPLTTPVGG GIRSLNVALR QLMDLYQCVR PVKYYSGVPS PVKSPEKLDV 150
    VIFRENTEDI YAGIEFREGT PEAAKFIAFV NDEMLKGTKK KVRLDSGVGV 200
    KPISITGSKR LVRAAIQYAI DHQRKTVTLV HKGNIQKFTE GAFREWGYEV 250
    ATQEFRAHTV TERESWILGN LEQNPKLTPE ENAALVEPGI EFASKEFGES 300
    IVQEVRDVVA SIGATHGNGQ WKNKILVNDR IADSIFQQII IRPSDYSVLA 350
    TTNLNGDYIS DAAAAQVGGL GIAPGANIGD GYAVFEATHG TAPKYADKDV 400
    INPGSVMLSG VMMFDFLGWS EAARLIESSM EKTIQQKFVT YDFERQMQGA 450
    TKAKTSEFAS RMIENMG 467
    Length:467
    Mass (Da):51,555
    Last modified:February 22, 2012 - v1
    Checksum:i1639DD4FA8D86935
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003130 Genomic DNA. Translation: AEU35629.1.
    RefSeqiYP_005056659.1. NC_016631.1.

    Genome annotation databases

    EnsemblBacteriaiAEU35629; AEU35629; AciX8_1286.
    GeneIDi11571735.
    KEGGigma:AciX8_1286.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003130 Genomic DNA. Translation: AEU35629.1 .
    RefSeqi YP_005056659.1. NC_016631.1.

    3D structure databases

    ProteinModelPortali G8NYX7.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEU35629 ; AEU35629 ; AciX8_1286 .
    GeneIDi 11571735.
    KEGGi gma:AciX8_1286.

    Phylogenomic databases

    KOi K00031.

    Enzyme and pathway databases

    BioCyci GMAL682795:GHBV-1303-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 2 hits.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Granulicella mallensis MP5ACTX8."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Lu M., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Mikhailova N., Pagani I., Rawat S.
      , Mannisto M., Haggblom M., Woyke T.
      Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-1857 / DSM 23137 / MP5ACTX8Imported.

    Entry informationi

    Entry nameiG8NYX7_GRAMM
    AccessioniPrimary (citable) accession number: G8NYX7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 22, 2012
    Last sequence update: February 22, 2012
    Last modified: October 1, 2014
    This is version 12 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3