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G8NSU7

- G8NSU7_GRAMM

UniProt

G8NSU7 - G8NSU7_GRAMM

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Protein

Acetylornithine aminotransferase

Gene

argD

Organism
Granulicella mallensis (strain ATCC BAA-1857 / DSM 23137 / MP5ACTX8)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

N(2)-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate.UniRule annotation

Cofactori

Note: Binds 1 pyridoxal phosphate per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei171 – 1711Pyridoxal phosphate; via carbonyl oxygenUniRule annotation
Binding sitei174 – 1741N2-acetyl-L-ornithineUniRule annotation
Binding sitei337 – 3371N2-acetyl-L-ornithineUniRule annotation
Binding sitei338 – 3381Pyridoxal phosphateUniRule annotation

GO - Molecular functioni

  1. N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

AminotransferaseUniRule annotationSAAS annotation, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciGMAL682795:GHBV-1986-MONOMER.
UniPathwayiUPA00068; UER00109.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylornithine aminotransferaseUniRule annotation (EC:2.6.1.11UniRule annotation)
Short name:
ACOATUniRule annotation
Gene namesi
Name:argDUniRule annotation
Ordered Locus Names:AciX8_1960Imported
OrganismiGranulicella mallensis (strain ATCC BAA-1857 / DSM 23137 / MP5ACTX8)Imported
Taxonomic identifieri682795 [NCBI]
Taxonomic lineageiBacteriaAcidobacteriaAcidobacterialesAcidobacteriaceaeGranulicella
ProteomesiUP000007113: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei310 – 3101N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliG8NSU7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni281 – 2844Pyridoxal phosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.UniRule annotation

Phylogenomic databases

KOiK00823.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01107. ArgD_aminotrans_3.
InterProiIPR004636. AcOrn/SuccOrn_fam.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G8NSU7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSILLEDRLT NQFQTVCDEE MARFGPKLKT VLPGPKAKAV IEADERFMSP
60 70 80 90 100
SYTRGYPLVA KRGRGTRMED VDGNEFLDFS AGIAVTSTGH CHPKVVKAIQ
110 120 130 140 150
EQAAELIHMS GTDFYYEGMP ALAQRLSAVA PMKGPHKFYY GNSGAEAVEC
160 170 180 190 200
ALKLARYHTG RQNIISFLGS FHGRTMGALS LTASKPQQKR RFAPLVPGVT
210 220 230 240 250
HVPYPYAYRG AGTGQSEDEY ALACARYIED RLFKTMLPPE EVAAIFVEPI
260 270 280 290 300
QGEGGYVVAP TVFLQELRNI CDRHGILLVV DEVQSGAGRT GKWWAVQHTG
310 320 330 340 350
VEPDMVCMAK GIASGMPLSV CMTRAEIMDW KPGSHASTFG GNPVAIAAAL
360 370 380 390 400
ATMDVLEEEA ISNAAAVGAE IKARAETWLS KYEIVGDIRG RGLMIGIEIV
410 420 430 440 450
KDKKSKQPHS AVRDAIVDRA FEHGLLFLGC GETSIRLSPP LTISREEAAI
460
AMDVLEQCIA EQC
Length:463
Mass (Da):50,369
Last modified:February 22, 2012 - v1
Checksum:i6B7B6A0434528647
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003130 Genomic DNA. Translation: AEU36290.1.
RefSeqiYP_005057320.1. NC_016631.1.

Genome annotation databases

EnsemblBacteriaiAEU36290; AEU36290; AciX8_1960.
GeneIDi11573066.
KEGGigma:AciX8_1960.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003130 Genomic DNA. Translation: AEU36290.1 .
RefSeqi YP_005057320.1. NC_016631.1.

3D structure databases

ProteinModelPortali G8NSU7.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEU36290 ; AEU36290 ; AciX8_1960 .
GeneIDi 11573066.
KEGGi gma:AciX8_1960.

Phylogenomic databases

KOi K00823.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00109 .
BioCyci GMAL682795:GHBV-1986-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_01107. ArgD_aminotrans_3.
InterProi IPR004636. AcOrn/SuccOrn_fam.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Granulicella mallensis MP5ACTX8."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Lu M., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Mikhailova N., Pagani I., Rawat S.
    , Mannisto M., Haggblom M., Woyke T.
    Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1857 / DSM 23137 / MP5ACTX8Imported.

Entry informationi

Entry nameiG8NSU7_GRAMM
AccessioniPrimary (citable) accession number: G8NSU7
Entry historyi
Integrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: November 26, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3