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G8NSU7

- G8NSU7_GRAMM

UniProt

G8NSU7 - G8NSU7_GRAMM

Protein

Acetylornithine aminotransferase

Gene

argD

Organism
Granulicella mallensis (strain ATCC BAA-1857 / DSM 23137 / MP5ACTX8)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 18 (01 Oct 2014)
      Sequence version 1 (22 Feb 2012)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    N(2)-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate.UniRule annotation

    Cofactori

    Binds 1 pyridoxal phosphate per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei171 – 1711Pyridoxal phosphate; via carbonyl oxygenUniRule annotation
    Binding sitei174 – 1741N2-acetyl-L-ornithineUniRule annotation
    Binding sitei337 – 3371N2-acetyl-L-ornithineUniRule annotation
    Binding sitei338 – 3381Pyridoxal phosphateUniRule annotation

    GO - Molecular functioni

    1. N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    AminotransferaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesisUniRule annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciGMAL682795:GHBV-1986-MONOMER.
    UniPathwayiUPA00068; UER00109.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetylornithine aminotransferaseUniRule annotation (EC:2.6.1.11UniRule annotation)
    Short name:
    ACOATUniRule annotation
    Gene namesi
    Name:argDUniRule annotation
    Ordered Locus Names:AciX8_1960Imported
    OrganismiGranulicella mallensis (strain ATCC BAA-1857 / DSM 23137 / MP5ACTX8)Imported
    Taxonomic identifieri682795 [NCBI]
    Taxonomic lineageiBacteriaAcidobacteriaAcidobacterialesAcidobacteriaceaeGranulicella
    ProteomesiUP000007113: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei310 – 3101N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliG8NSU7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni281 – 2844Pyridoxal phosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.UniRule annotation

    Phylogenomic databases

    KOiK00823.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPiMF_01107. ArgD_aminotrans_3.
    InterProiIPR004636. AcOrn/SuccOrn_fam.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR11986. PTHR11986. 1 hit.
    PfamiPF00202. Aminotran_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G8NSU7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSILLEDRLT NQFQTVCDEE MARFGPKLKT VLPGPKAKAV IEADERFMSP    50
    SYTRGYPLVA KRGRGTRMED VDGNEFLDFS AGIAVTSTGH CHPKVVKAIQ 100
    EQAAELIHMS GTDFYYEGMP ALAQRLSAVA PMKGPHKFYY GNSGAEAVEC 150
    ALKLARYHTG RQNIISFLGS FHGRTMGALS LTASKPQQKR RFAPLVPGVT 200
    HVPYPYAYRG AGTGQSEDEY ALACARYIED RLFKTMLPPE EVAAIFVEPI 250
    QGEGGYVVAP TVFLQELRNI CDRHGILLVV DEVQSGAGRT GKWWAVQHTG 300
    VEPDMVCMAK GIASGMPLSV CMTRAEIMDW KPGSHASTFG GNPVAIAAAL 350
    ATMDVLEEEA ISNAAAVGAE IKARAETWLS KYEIVGDIRG RGLMIGIEIV 400
    KDKKSKQPHS AVRDAIVDRA FEHGLLFLGC GETSIRLSPP LTISREEAAI 450
    AMDVLEQCIA EQC 463
    Length:463
    Mass (Da):50,369
    Last modified:February 22, 2012 - v1
    Checksum:i6B7B6A0434528647
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003130 Genomic DNA. Translation: AEU36290.1.
    RefSeqiYP_005057320.1. NC_016631.1.

    Genome annotation databases

    EnsemblBacteriaiAEU36290; AEU36290; AciX8_1960.
    GeneIDi11573066.
    KEGGigma:AciX8_1960.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003130 Genomic DNA. Translation: AEU36290.1 .
    RefSeqi YP_005057320.1. NC_016631.1.

    3D structure databases

    ProteinModelPortali G8NSU7.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEU36290 ; AEU36290 ; AciX8_1960 .
    GeneIDi 11573066.
    KEGGi gma:AciX8_1960.

    Phylogenomic databases

    KOi K00823.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00109 .
    BioCyci GMAL682795:GHBV-1986-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPi MF_01107. ArgD_aminotrans_3.
    InterProi IPR004636. AcOrn/SuccOrn_fam.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR11986. PTHR11986. 1 hit.
    Pfami PF00202. Aminotran_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Granulicella mallensis MP5ACTX8."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Lu M., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Mikhailova N., Pagani I., Rawat S.
      , Mannisto M., Haggblom M., Woyke T.
      Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-1857 / DSM 23137 / MP5ACTX8Imported.

    Entry informationi

    Entry nameiG8NSU7_GRAMM
    AccessioniPrimary (citable) accession number: G8NSU7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 22, 2012
    Last sequence update: February 22, 2012
    Last modified: October 1, 2014
    This is version 18 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Miscellaneous

    May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3