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Protein

Elongation factor Tu

Gene

tuf

Organism
Granulicella mallensis (strain ATCC BAA-1857 / DSM 23137 / MP5ACTX8)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi19 – 268GTPUniRule annotation
Nucleotide bindingi82 – 865GTPUniRule annotation
Nucleotide bindingi137 – 1404GTPUniRule annotation

GO - Molecular functioni

  1. GTPase activity Source: InterPro
  2. GTP binding Source: UniProtKB-HAMAP
  3. translation elongation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Elongation factorUniRule annotation

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciGMAL682795:GHBV-574-MONOMER.
GMAL682795:GHBV-776-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor TuUniRule annotation
Short name:
EF-TuUniRule annotation
Gene namesi
Name:tufUniRule annotation
Ordered Locus Names:AciX8_0571Imported, AciX8_0764Imported
OrganismiGranulicella mallensis (strain ATCC BAA-1857 / DSM 23137 / MP5ACTX8)Imported
Taxonomic identifieri682795 [NCBI]
Taxonomic lineageiBacteriaAcidobacteriaAcidobacterialesAcidobacteriaceaeGranulicella
ProteomesiUP000007113: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliG8NSL4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.UniRule annotation

Phylogenomic databases

KOiK02358.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00118_B. EF_Tu_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004541. Transl_elong_EFTu/EF1A_bac/org.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00485. EF-Tu. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. EFACTOR_GTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G8NSL4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKEKFDRSK PHVNIGTIGH IDHGKTTLTA AITKVLSKHN PKNSFRSFDT
60 70 80 90 100
IDNAPEERER GITISTSHVE YETPNRHYAH VDCPGHADYI KNMITGAAQM
110 120 130 140 150
DGAILVVAAT DGPMPQTKEH VLLARQVGVP YIVVFLNKCD AVEDEELIEL
160 170 180 190 200
VEMEVRELLS KYEYPGDETP IIRGSALGAL NGEAQWEAKI DELMAAVDKY
210 220 230 240 250
IPQPDRLVDL PFLMPIEDIF SISGRGTVVT GRIERGKVKV GEAAEIVGFR
260 270 280 290 300
DTQNTVVTGV EMFKKQLDEG LAGDNAGLLL RGIAKEDVER GMVLAKPGSI
310 320 330 340 350
KPHTQFKGEI YVLSKEEGGR HTPFFNGYRP QFYFRTTDVT GSAKLPEGTE
360 370 380 390
MVMPGDNISL EITLHTPVAM EKGLRFAIRE GGRTVGAGTI SEIIK
Length:395
Mass (Da):43,439
Last modified:February 22, 2012 - v1
Checksum:i6168E3DB17944AAD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003130 Genomic DNA. Translation: AEU34921.1.
CP003130 Genomic DNA. Translation: AEU35113.1.
RefSeqiYP_005055951.1. NC_016631.1.
YP_005056143.1. NC_016631.1.

Genome annotation databases

EnsemblBacteriaiAEU34921; AEU34921; AciX8_0571.
AEU35113; AEU35113; AciX8_0764.
GeneIDi11575318.
11575520.
KEGGigma:AciX8_0571.
gma:AciX8_0764.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003130 Genomic DNA. Translation: AEU34921.1.
CP003130 Genomic DNA. Translation: AEU35113.1.
RefSeqiYP_005055951.1. NC_016631.1.
YP_005056143.1. NC_016631.1.

3D structure databases

ProteinModelPortaliG8NSL4.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEU34921; AEU34921; AciX8_0571.
AEU35113; AEU35113; AciX8_0764.
GeneIDi11575318.
11575520.
KEGGigma:AciX8_0571.
gma:AciX8_0764.

Phylogenomic databases

KOiK02358.

Enzyme and pathway databases

BioCyciGMAL682795:GHBV-574-MONOMER.
GMAL682795:GHBV-776-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00118_B. EF_Tu_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004541. Transl_elong_EFTu/EF1A_bac/org.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00485. EF-Tu. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. EFACTOR_GTP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of Granulicella mallensis MP5ACTX8."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Lu M., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Mikhailova N., Pagani I., Rawat S.
    , Mannisto M., Haggblom M., Woyke T.
    Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1857 / DSM 23137 / MP5ACTX8Imported and MP5ACTX8Imported.

Entry informationi

Entry nameiG8NSL4_GRAMM
AccessioniPrimary (citable) accession number: G8NSL4
Entry historyi
Integrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: November 26, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.