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G8NCT6

- G8NCT6_9DEIN

UniProt

G8NCT6 - G8NCT6_9DEIN

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Protein

Thymidine kinase

Gene

tdk

Organism
Thermus sp. CCB_US3_UF1
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei86 – 861Proton acceptorUniRule annotation
Metal bindingi142 – 1421ZincUniRule annotation
Metal bindingi145 – 1451ZincUniRule annotation
Metal bindingi180 – 1801ZincUniRule annotation
Metal bindingi183 – 1831ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 198ATPUniRule annotation
Nucleotide bindingi85 – 884ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciTSP1111069:GLMD-1062-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
ORF Names:TCCBUS3UF1_10540Imported
OrganismiThermus sp. CCB_US3_UF1Imported
Taxonomic identifieri1111069 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
ProteomesiUP000005635: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

KOiK00857.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G8NCT6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHRQGWIEVI AGPMFSGKSE ELIRRVKRAL IARQRVLVFK PRLDNRYGEG
60 70 80 90 100
HVVSHDGERV EAIPIARAEE MEAYLKPLPQ VVAVDEVQFL DRALLPLVER
110 120 130 140 150
LAQEGVRVIL AGLDLDFRGE PFGLMPELLA RAEFVEKLTA ICPRCGAPAT
160 170 180
RTQRLVDGKP ARYTDPIILV GAQEHYEPRC RACHQVAY
Length:188
Mass (Da):21,230
Last modified:February 22, 2012 - v1
Checksum:i3DAA9E80BA3F28D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003126 Genomic DNA. Translation: AEV16099.1.
RefSeqiWP_014515458.1. NC_017278.1.
YP_005654173.1. NC_017278.1.

Genome annotation databases

EnsemblBacteriaiAEV16099; AEV16099; TCCBUS3UF1_10540.
GeneIDi12253041.
KEGGithc:TCCBUS3UF1_10540.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003126 Genomic DNA. Translation: AEV16099.1 .
RefSeqi WP_014515458.1. NC_017278.1.
YP_005654173.1. NC_017278.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEV16099 ; AEV16099 ; TCCBUS3UF1_10540 .
GeneIDi 12253041.
KEGGi thc:TCCBUS3UF1_10540.

Phylogenomic databases

KOi K00857.

Enzyme and pathway databases

BioCyci TSP1111069:GLMD-1062-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of thermophilic Thermus sp. CCB_US3_UF1."
    Teh B.S., Abdul Rahman A.Y., Saito J.A., Hou S., Alam M.
    Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: CCB_US3_UF1Imported.

Entry informationi

Entry nameiG8NCT6_9DEIN
AccessioniPrimary (citable) accession number: G8NCT6
Entry historyi
Integrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: November 26, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3