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G8NCT6

- G8NCT6_9DEIN

UniProt

G8NCT6 - G8NCT6_9DEIN

Protein

Thymidine kinase

Gene

tdk

Organism
Thermus sp. CCB_US3_UF1
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 17 (01 Oct 2014)
      Sequence version 1 (22 Feb 2012)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei86 – 861Proton acceptorUniRule annotation
    Metal bindingi142 – 1421ZincUniRule annotation
    Metal bindingi145 – 1451ZincUniRule annotation
    Metal bindingi180 – 1801ZincUniRule annotation
    Metal bindingi183 – 1831ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi12 – 198ATPUniRule annotation
    Nucleotide bindingi85 – 884ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. thymidine kinase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    KinaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    DNA synthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciTSP1111069:GLMD-1062-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
    Gene namesi
    Name:tdkUniRule annotation
    ORF Names:TCCBUS3UF1_10540Imported
    OrganismiThermus sp. CCB_US3_UF1Imported
    Taxonomic identifieri1111069 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
    ProteomesiUP000005635: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotationSAAS annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine kinase family.UniRule annotation

    Phylogenomic databases

    KOiK00857.

    Family and domain databases

    HAMAPiMF_00124. Thymidine_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view]
    PANTHERiPTHR11441. PTHR11441. 1 hit.
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF035805. TK_cell. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G8NCT6-1 [UniParc]FASTAAdd to Basket

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    MHRQGWIEVI AGPMFSGKSE ELIRRVKRAL IARQRVLVFK PRLDNRYGEG    50
    HVVSHDGERV EAIPIARAEE MEAYLKPLPQ VVAVDEVQFL DRALLPLVER 100
    LAQEGVRVIL AGLDLDFRGE PFGLMPELLA RAEFVEKLTA ICPRCGAPAT 150
    RTQRLVDGKP ARYTDPIILV GAQEHYEPRC RACHQVAY 188
    Length:188
    Mass (Da):21,230
    Last modified:February 22, 2012 - v1
    Checksum:i3DAA9E80BA3F28D1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003126 Genomic DNA. Translation: AEV16099.1.
    RefSeqiWP_014515458.1. NC_017278.1.
    YP_005654173.1. NC_017278.1.

    Genome annotation databases

    EnsemblBacteriaiAEV16099; AEV16099; TCCBUS3UF1_10540.
    GeneIDi12253041.
    KEGGithc:TCCBUS3UF1_10540.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003126 Genomic DNA. Translation: AEV16099.1 .
    RefSeqi WP_014515458.1. NC_017278.1.
    YP_005654173.1. NC_017278.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEV16099 ; AEV16099 ; TCCBUS3UF1_10540 .
    GeneIDi 12253041.
    KEGGi thc:TCCBUS3UF1_10540.

    Phylogenomic databases

    KOi K00857.

    Enzyme and pathway databases

    BioCyci TSP1111069:GLMD-1062-MONOMER.

    Family and domain databases

    HAMAPi MF_00124. Thymidine_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view ]
    PANTHERi PTHR11441. PTHR11441. 1 hit.
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF035805. TK_cell. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of thermophilic Thermus sp. CCB_US3_UF1."
      Teh B.S., Abdul Rahman A.Y., Saito J.A., Hou S., Alam M.
      Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: CCB_US3_UF1Imported.

    Entry informationi

    Entry nameiG8NCT6_9DEIN
    AccessioniPrimary (citable) accession number: G8NCT6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 22, 2012
    Last sequence update: February 22, 2012
    Last modified: October 1, 2014
    This is version 17 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3