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G8NCT6

- G8NCT6_9DEIN

UniProt

G8NCT6 - G8NCT6_9DEIN

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Protein

Thymidine kinase

Gene
tdk, TCCBUS3UF1_10540
Organism
Thermus sp. CCB_US3_UF1
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei86 – 861Proton acceptor By similarityUniRule annotation
Metal bindingi142 – 1421Zinc By similarityUniRule annotation
Metal bindingi145 – 1451Zinc By similarityUniRule annotation
Metal bindingi180 – 1801Zinc By similarityUniRule annotation
Metal bindingi183 – 1831Zinc By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 198ATP By similarityUniRule annotation
Nucleotide bindingi85 – 884ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding, ZincUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciTSP1111069:GLMD-1062-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
ORF Names:TCCBUS3UF1_10540Imported
OrganismiThermus sp. CCB_US3_UF1Imported
Taxonomic identifieri1111069 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
ProteomesiUP000005635: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotationSAAS annotations

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

KOiK00857.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G8NCT6-1 [UniParc]FASTAAdd to Basket

« Hide

MHRQGWIEVI AGPMFSGKSE ELIRRVKRAL IARQRVLVFK PRLDNRYGEG    50
HVVSHDGERV EAIPIARAEE MEAYLKPLPQ VVAVDEVQFL DRALLPLVER 100
LAQEGVRVIL AGLDLDFRGE PFGLMPELLA RAEFVEKLTA ICPRCGAPAT 150
RTQRLVDGKP ARYTDPIILV GAQEHYEPRC RACHQVAY 188
Length:188
Mass (Da):21,230
Last modified:February 22, 2012 - v1
Checksum:i3DAA9E80BA3F28D1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003126 Genomic DNA. Translation: AEV16099.1.
RefSeqiWP_014515458.1. NC_017278.1.
YP_005654173.1. NC_017278.1.

Genome annotation databases

EnsemblBacteriaiAEV16099; AEV16099; TCCBUS3UF1_10540.
GeneIDi12253041.
KEGGithc:TCCBUS3UF1_10540.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003126 Genomic DNA. Translation: AEV16099.1 .
RefSeqi WP_014515458.1. NC_017278.1.
YP_005654173.1. NC_017278.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEV16099 ; AEV16099 ; TCCBUS3UF1_10540 .
GeneIDi 12253041.
KEGGi thc:TCCBUS3UF1_10540.

Phylogenomic databases

KOi K00857.

Enzyme and pathway databases

BioCyci TSP1111069:GLMD-1062-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of thermophilic Thermus sp. CCB_US3_UF1."
    Teh B.S., Abdul Rahman A.Y., Saito J.A., Hou S., Alam M.
    Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: CCB_US3_UF1Imported.

Entry informationi

Entry nameiG8NCT6_9DEIN
AccessioniPrimary (citable) accession number: G8NCT6
Entry historyi
Integrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: September 3, 2014
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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