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G8NAZ3 (G8NAZ3_9DEIN) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 17. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
ORF Names:TCCBUS3UF1_7140 EMBL AEV15762.1
OrganismThermus sp. CCB_US3_UF1 [Complete proteome] EMBL AEV15762.1
Taxonomic identifier1111069 [NCBI]
Taxonomic lineageBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus

Protein attributes

Sequence length322 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS011095

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS011095

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS011095.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011095

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain123 – 318196ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding150 – 20152ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2731Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2851Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2851Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2871Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
G8NAZ3 [UniParc].

Last modified February 22, 2012. Version 1.
Checksum: C32760AB893D2416

FASTA32235,056
        10         20         30         40         50         60 
MALPRVLLIA GGRSPEHEVS LLSARGVLEH MPFPTELAVI AKDGGWLLGE RALGALGAGQ 

        70         80         90        100        110        120 
ALQGEHPFPP DLDWNRYDVV FPLLHGRWGE DGTLQGFLEL LGRPYVGAGV AASALCMDKD 

       130        140        150        160        170        180 
LSKRVLAQAG VPVVPWVALY PGERPFLPFE PPYFVKPANT GSSVGIRRVE SHAGLEEALE 

       190        200        210        220        230        240 
EAFRHDGKAV VEKALLGVRE LEVGVLGNVF AEASPVGEVR YQAPFYDYET KYTPGRAELL 

       250        260        270        280        290        300 
IPAPLDPGTQ ETIQEMALKA YRLLGIRGMA RVDFFLVEGE VYLNEINTIP GFTPTSMYPK 

       310        320 
LFQAAGVSYP ELLKRLVELA LA 

« Hide

References

[1]"Complete genome sequence of thermophilic Thermus sp. CCB_US3_UF1."
Teh B.S., Abdul Rahman A.Y., Saito J.A., Hou S., Alam M.
Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: CCB_US3_UF1 EMBL AEV15762.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP003126 Genomic DNA. Translation: AEV15762.1.
RefSeqYP_005653836.1. NC_017278.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEV15762; AEV15762; TCCBUS3UF1_7140.
GeneID12252701.
KEGGthc:TCCBUS3UF1_7140.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.

Enzyme and pathway databases

BioCycTSP1111069:GLMD-722-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG8NAZ3_9DEIN
AccessionPrimary (citable) accession number: G8NAZ3
Entry history
Integrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: June 11, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)