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G8LUL4 (G8LUL4_CLOCD) Unreviewed, UniProtKB/TrEMBL

Last modified May 29, 2013. Version 11. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Acetolactate synthase RuleBase RU003591
EC=2.2.1.6 RuleBase RU003591
Gene names
Ordered Locus Names:Clocl_0647 EMBL AEV67354.1
OrganismClostridium clariflavum (strain DSM 19732 / NBRC 101661 / EBR45) [Complete proteome] [HAMAP] EMBL AEV67354.1
Taxonomic identifier720554 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium ›

Protein attributes

Sequence length555 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2 pyruvate = 2-acetolactate + CO2.

Cofactor

Binds 1 magnesium ion per subunit By similarity.

Binds 1 thiamine pyrophosphate per subunit By similarity.

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.

Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.

Sequence similarities

Belongs to the TPP enzyme family. RuleBase RU003702

Sequences

Sequence LengthMass (Da)Tools
G8LUL4 [UniParc].

Last modified February 22, 2012. Version 1.
Checksum: 1D571B99951DF3F9

FASTA55560,236
        10         20         30         40         50         60 
MKLTGAQILI ECLKEQGVDT IFGFPGGAVL NIYDALFKAK DDIRHILTSH EQGAAHAADG 

        70         80         90        100        110        120 
YARATGKVGV CIATSGPGAT NLVTGIATAY MDSVPMVAIT GQVPTTLLGK DSFQEVDITG 

       130        140        150        160        170        180 
ITMPITKHNY IVKDVERLAD IVREAFIIAK EGRPGPVLID ICKDVTAAVT EYVPKVPKKP 

       190        200        210        220        230        240 
EEASLGVTED EIDAAADAIN KAKRPIILSG GGVSIAGANE EVFELANKAL IPVTTTLMGI 

       250        260        270        280        290        300 
GSFPGTHELF TGMVGMHGTK TTNMAVSESD LFIAIGARFS DRVISDVNRF APNAKIMHID 

       310        320        330        340        350        360 
IDPAEVGKNV AVDYPLVGNI KKILKRLIAK VEKKEQSDWK NKIDEWKRLY PLKYPKDDVL 

       370        380        390        400        410        420 
RPNYIVERLY ELTKGDAIIT TEVGQHQIWA AQFYKFKSPR QFLSSGGLGT MGYGLGASIG 

       430        440        450        460        470        480 
AKLGRPDKKV INIAGDGSFR MNCNELATAV EYKLPIIIAI FNNHVLGMVR QWQNLFYDGR 

       490        500        510        520        530        540 
YSSTNIDRGT NFVALAEAYG AIGIDVRKPE EVDEAWKKAL ASKDTPVVIN FEIDKDDKVF 

       550 
PIVPPGAAIS DLIEE

« Hide

References

[1]"Complete sequence of Clostridium clariflavum DSM 19732."
US DOE Joint Genome Institute
Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Teshima H., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Kitzmiller T., Lynd L., Izquierdo J., Woyke T.
Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 19732 / NBRC 101661 / EBR45.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP003065 Genomic DNA. Translation: AEV67354.1.
RefSeqYP_005045278.1. NC_016627.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEV67354; AEV67354; Clocl_0647.
GeneID11561017.
KEGGccl:Clocl_0647.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01652.

Enzyme and pathway databases

BioCycCCLA720554:GI2T-646-MONOMER.
UniPathwayUPA00047; UER00055.
UPA00049; UER00059.

Family and domain databases

InterProIPR012846. Acetolactate_synth_lsu.
IPR012000. Thiamin_PyroP_enz_cen_dom.
IPR012001. Thiamin_PyroP_enz_TPP-bd_dom.
IPR000399. TPP-bd_CS.
IPR011766. TPP_enzyme-bd_C.
[Graphical view]
PANTHERPTHR18968:SF13. PTHR18968:SF13. 1 hit.
PfamPF02775. TPP_enzyme_C. 1 hit.
PF00205. TPP_enzyme_M. 1 hit.
PF02776. TPP_enzyme_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR00118. acolac_lg. 1 hit.
PROSITEPS00187. TPP_ENZYMES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG8LUL4_CLOCD
AccessionPrimary (citable) accession number: G8LUL4
Entry history
Integrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: May 29, 2013
This is version 11 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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