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G8LRG0 (G8LRG0_9FLAO) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 17. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047 EMBL AEU09183.1
ORF Names:BLBCPU_117 EMBL AEU09183.1
OrganismBlattabacterium sp. (Cryptocercus punctulatus) str. Cpu [Complete proteome] EMBL AEU09183.1
Taxonomic identifier1075399 [NCBI]
Taxonomic lineageBacteriaBacteroidetesFlavobacteriiaFlavobacterialesBlattabacteriaceaeBlattabacterium

Protein attributes

Sequence length324 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain120 – 319200ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding148 – 20356ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2741Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2861Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2861Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2881Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
G8LRG0 [UniParc].

Last modified February 22, 2012. Version 1.
Checksum: 13382105DD8C9827

FASTA32436,932
        10         20         30         40         50         60 
MKKIAIIMGG YTEESIISLK SGKIVYENLN REEFDPYQIY IFKDKWVLIG EKKEYSINKQ 

        70         80         90        100        110        120 
DFTILLKSNQ ILKFDCVFNA IHGTPGEDGI LPAYFHLLKI PYTGCNFHQA NVTFNKKYCL 

       130        140        150        160        170        180 
TLLKEFGINT AISFFLNQNQ PFCEKKIIKK IGLPCFVKPN RSGSSLGISK VYKKEELFPA 

       190        200        210        220        230        240 
IKKAFKKDDE IIIESFLKGI EISVGVISFN HEITVLPITE IISKNDFFDF ESKYDEGSQE 

       250        260        270        280        290        300 
ITPARLLPNM ENKIQKLVKK ICKILNLSGI SRSEFILVNG EPFFLEINTV PGLSKKSIFP 

       310        320 
KQLNVAGISI SNLLKKLIDF SIKN 

« Hide

References

[1]"Genome economization in the endosymbiont of the wood roach Cryptocercus punctulatus due to drastic loss of amino acid synthesis capabilities."
Neef A., Latorre A., Pereto J., Silva F.J., Pignatelli M., Moya A.
Genome Biol. Evol. 3:1437-1448(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Cpu EMBL AEU09183.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP003015 Genomic DNA. Translation: AEU09183.1.
RefSeqYP_005037256.1. NC_016621.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEU09183; AEU09183; BLBCPU_117.
GeneID11552366.
KEGGbcp:BLBCPU_117.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.

Enzyme and pathway databases

BioCycBPUN1075399:GJY7-117-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG8LRG0_9FLAO
AccessionPrimary (citable) accession number: G8LRG0
Entry history
Integrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: February 19, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)