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Protein

Thymidine kinase

Gene

tdk

Organism
Enterobacter cloacae EcWSU1
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei95Proton acceptorUniRule annotation1
Metal bindingi152ZincUniRule annotation1
Metal bindingi154ZincUniRule annotation1
Metal bindingi189ZincUniRule annotation1
Metal bindingi192ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi16 – 23ATPUniRule annotation8
Nucleotide bindingi94 – 97ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processDNA synthesisUniRule annotation
LigandATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
ORF Names:EcWSU1_02589Imported
OrganismiEnterobacter cloacae EcWSU1Imported
Taxonomic identifieri1045856 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEnterobacterEnterobacter cloacae complex
Proteomesi
  • UP000007838 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi1045856.EcWSU1_02589.

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107104. Bacteria.
COG1435. LUCA.
KOiK00857.
OrthoDBiPOG091H0659.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase. 1 hit.
InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiView protein in Pfam
PF00265. TK. 1 hit.
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00603. TK_CELLULAR_TYPE. 1 hit.

Sequencei

Sequence statusi: Complete.

G8LEG5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRVLRPMAQ LYFYYSAMNA GKSTALLQSS YNYQERGMRT VVYTAEIDDR
60 70 80 90 100
FGAGKVSSRI GLSSPARLFN PQTDLLEDIR TAHASQPIHC VLVDESQFLT
110 120 130 140 150
REQVHALSEV VDELDIPVLC YGLRTDFRGE LFAGSQYLLA WSDKLVELKT
160 170 180 190 200
ICFCGRKASM VLRLDQAGKP YADGEQVVIG GNERYVSVCR KHYKEALIVG
210
SLTALQPDNR K
Length:211
Mass (Da):23,722
Last modified:February 22, 2012 - v1
Checksum:iFFAB73B0A18EBEE9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002886 Genomic DNA. Translation: AEW74023.1.

Genome annotation databases

EnsemblBacteriaiAEW74023; AEW74023; EcWSU1_02589.
KEGGieec:EcWSU1_02589.

Similar proteinsi

Entry informationi

Entry nameiG8LEG5_ENTCL
AccessioniPrimary (citable) accession number: G8LEG5
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: September 27, 2017
This is version 32 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported