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Protein

Signal transducer and activator of transcription

Gene

STAT3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivatorUniRule annotation, DNA-bindingUniRule annotation
Biological processTranscription, Transcription regulationUniRule annotation

Enzyme and pathway databases

SignaLinkiG8JLH9

Names & Taxonomyi

Protein namesi
Recommended name:
Signal transducer and activator of transcriptionUniRule annotation
Gene namesi
Name:STAT3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000168610.14
HGNCiHGNC:11364 STAT3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000168610

PTM / Processingi

Keywords - PTMi

PhosphoproteinUniRule annotation

Proteomic databases

MaxQBiG8JLH9
PeptideAtlasiG8JLH9
PRIDEiG8JLH9

Expressioni

Gene expression databases

BgeeiENSG00000168610
ExpressionAtlasiG8JLH9 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliG8JLH9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini482 – 572SH2InterPro annotationAdd BLAST91

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili43 – 70Sequence analysisAdd BLAST28
Coiled coili172 – 192Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the transcription factor STAT family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, SH2 domainPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3667 Eukaryota
ENOG410XPN8 LUCA
GeneTreeiENSGT00760000119236

Family and domain databases

CDDicd10374 SH2_STAT3, 1 hit
Gene3Di2.60.40.630, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR008967 p53-like_TF_DNA-bd
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR001217 STAT
IPR035855 STAT3_SH2
IPR013800 STAT_TF_alpha
IPR015988 STAT_TF_coiled-coil
IPR013801 STAT_TF_DNA-bd
IPR012345 STAT_TF_DNA-bd_N
PANTHERiPTHR11801 PTHR11801, 1 hit
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PF01017 STAT_alpha, 1 hit
PF02864 STAT_bind, 1 hit
SUPFAMiSSF47655 SSF47655, 1 hit
SSF49417 SSF49417, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit

Sequencei

Sequence statusi: Complete.

G8JLH9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIARIVARC LWEESRLLQT AATAAQQGGQ ANHPTAAVVT EKQQMLEQHL
60 70 80 90 100
QDVRKRVQDL EQKMKVVENL QDDFDFNYKT LKSQGDMQDL NGNNQSVTRQ
110 120 130 140 150
KMQQLEQMLT ALDQMRRSIV SELAGLLSAM EYVQKTLTDE ELADWKRRQQ
160 170 180 190 200
IACIGGPPNI CLDRLENWIT SLAESQLQTR QQIKKLEELQ QKVSYKGDPI
210 220 230 240 250
VQHRPMLEER IVELFRNLMK SAFVVERQPC MPMHPDRPLV IKTGVQFTTK
260 270 280 290 300
VRLLVKFPEL NYQLKIKVCI DKDSGDVAAL RGSRKFNILG TNTKVMNMEE
310 320 330 340 350
SNNGSLSAEF KHLTLREQRC GNGGRANCDA SLIVTEELHL ITFETEVYHQ
360 370 380 390 400
GLKIDLETHS LPVVVISNIC QMPNAWASIL WYNMLTNNPK NVNFFTKPPI
410 420 430 440 450
GTWDQVAEVL SWQFSSTTKR GLSIEQLTTL AEKLLGPGVN YSGCQITWAK
460 470 480 490 500
FCKENMAGKG FSFWVWLDNI IDLVKKYILA LWNEGYIMGF ISKERERAIL
510 520 530 540 550
STKPPGTFLL RFSESSKEGG VTFTWVEKDI SGKTQIQSVE PYTKQQLNNM
560 570 580 590 600
SFAEIIMGYK IMDATNILVS PLVYLYPDIP KEEAFGKYCR PESQEHPEAD
610 620 630 640 650
PGSAAPYLKT KFICVTPTTC SNTIDLPMSP RTLDSLMQFG NNGEGAEPSA
660 670
GGQFESLTFD MELTSECATS PM
Length:672
Mass (Da):76,138
Last modified:January 25, 2012 - v1
Checksum:i5C08B2086EE33D40
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC087691 Genomic DNA No translation available.
AC107993 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000389272; ENSP00000373923; ENSG00000168610
UCSCiuc010wgh.2 human

Entry informationi

Entry nameiG8JLH9_HUMAN
AccessioniPrimary (citable) accession number: G8JLH9
Entry historyiIntegrated into UniProtKB/TrEMBL: January 25, 2012
Last sequence update: January 25, 2012
Last modified: April 25, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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