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Protein

Structural maintenance of chromosomes protein

Gene

SMC1A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Structural maintenance of chromosomes proteinUniRule annotation
Gene namesi
Name:SMC1AImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:11111. SMC1A.

Subcellular locationi

  • Nucleus UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

PTM / Processingi

Proteomic databases

PaxDbiG8JLG1.
PeptideAtlasiG8JLG1.

Expressioni

Gene expression databases

BgeeiENSG00000072501.
ExpressionAtlasiG8JLG1. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000323421.

Structurei

3D structure databases

ProteinModelPortaliG8JLG1.
SMRiG8JLG1. Positions 477-653.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini491 – 607117SMC_hingeInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili167 – 20034Sequence analysisAdd
BLAST
Coiled coili210 – 27162Sequence analysisAdd
BLAST
Coiled coili280 – 33859Sequence analysisAdd
BLAST
Coiled coili343 – 37735Sequence analysisAdd
BLAST
Coiled coili385 – 46884Sequence analysisAdd
BLAST
Coiled coili642 – 68948Sequence analysisAdd
BLAST
Coiled coili726 – 75328Sequence analysisAdd
BLAST
Coiled coili767 – 79226Sequence analysisAdd
BLAST
Coiled coili806 – 90398Sequence analysisAdd
BLAST
Coiled coili970 – 99425Sequence analysisAdd
BLAST
Coiled coili1002 – 104342Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the SMC family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0018. Eukaryota.
COG1196. LUCA.
GeneTreeiENSGT00580000081569.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR027417. P-loop_NTPase.
IPR003395. RecF/RecN/SMC_N.
IPR024704. SMC.
IPR029683. SMC1A_metazoan.
IPR010935. SMC_hinge.
[Graphical view]
PANTHERiPTHR18937:SF170. PTHR18937:SF170. 3 hits.
PfamiPF06470. SMC_hinge. 1 hit.
PF02463. SMC_N. 1 hit.
[Graphical view]
PIRSFiPIRSF005719. SMC. 1 hit.
SMARTiSM00968. SMC_hinge. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
SSF75553. SSF75553. 1 hit.

Sequencei

Sequence statusi: Complete.

G8JLG1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLEVSIPTPH RYVRGKSNLM DAISFVLGEK TSNLRVKTLR DLIHGAPVGK
60 70 80 90 100
PAANRAFVSM VYSEEGAEDR TFARVIVGGS SEYKINNKVV QLHEYSEELE
110 120 130 140 150
KLGILIKARN FLVFQGAVES IAMKNPKERT ALFEEISRSG ELAQEYDKRK
160 170 180 190 200
KEMVKAEEDT QFNYHRKKNI AAERKEAKQE KEEADRYQRL KDEVVRAQVQ
210 220 230 240 250
LQLFKLYHNE VEIEKLNKEL ASKNKEIEKD KKRMDKVEDE LKEKKKELGK
260 270 280 290 300
MMREQQQIEK EIKEKDSELN QKRPQYIKAK ENTSHKIKKL EAAKKSLQNA
310 320 330 340 350
QKHYKKRKGD MDELEKEMLS VEKARQEFEE RMEEESQSQG RDLTLEENQV
360 370 380 390 400
KKYHRLKEEA SKRAATLAQE LEKFNRDQKA DQDRLDLEER KKVETEAKIK
410 420 430 440 450
QKLREIEENQ KRIEKLEEYI TTSKQSLEEQ KKLEGELTEE VEMAKRRIDE
460 470 480 490 500
INKELNQVME QLGDARIDRQ ESSRQQRKAE IMESIKRLYP GSVYGRLIDL
510 520 530 540 550
CQPTQKKYQI AVTKVLGKNM DAIIVDSEKT GRDCIQYIKE QRGEPETFLP
560 570 580 590 600
LDYLEVKPTD EKLRELKGAK LVIDVIRYEP PHIKKALQYA CGNALVCDNV
610 620 630 640 650
EDARRIAFGG HQRHKTVALD GTLFQKSGVI SGGASDLKAK ARRWDEKAVD
660 670 680 690 700
KLKEKKERLT EELKEQMKAK RKEAELRQVQ SQAHGLQMRL KYSQSDLEQT
710 720 730 740 750
KTRHLALNLQ EKSKLESELA NFGPRINDIK RIIQSREREM KDLKEKMNQV
760 770 780 790 800
EDEVFEEFCR EIGVRNIREF EEEKVKRQNE IAKKRLEFEN QKTRLGIQLD
810 820 830 840 850
FEKNQLKEDQ DKVHMWEQTV KKDENEIEKL KKEEQRHMKI IDETMAQLQD
860 870 880 890 900
LKNQHLAKKS EVNDKNHEME EIRKKLGGAN KEMTHLQKEV TAIETKLEQK
910 920 930 940 950
RSDRHNLLQA CKMQDIKLPL SKGTMDDISQ EEGSSQGEDS VSGSQRISSI
960 970 980 990 1000
YAREALIEID YGDLCEDLKD AQAEEEIKQE MNTLQQKLNE QQSVLQRIAA
1010 1020 1030 1040 1050
PNMKAMEKLE SVRDKFQETS DEFEAARKRA KKAKQAFEQI KKERFDRFNA
1060 1070 1080 1090 1100
CFESVATNID EIYKALSRNS SAQAFLGPEN PEEPYLDGIN YNCVAPGKRF
1110 1120 1130 1140 1150
RPMDNLSGGE KTVAALALLF AIHSYKPAPF FVLDEIDAAL DNTNIGKVAN
1160 1170 1180 1190 1200
YIKEQSTCNF QAIVISLKEE FYTKAESLIG VYPEQGDCVI SKVLTFDLTK
1210
YPDANPNPNE Q
Length:1,211
Mass (Da):140,859
Last modified:October 29, 2014 - v2
Checksum:i9E837EFEA36AD4D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC233728 Genomic DNA. No translation available.
RefSeqiNP_001268392.1. NM_001281463.1.
UniGeneiHs.211602.

Genome annotation databases

EnsembliENST00000375340; ENSP00000364489; ENSG00000072501.
GeneIDi8243.
UCSCiuc011moe.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC233728 Genomic DNA. No translation available.
RefSeqiNP_001268392.1. NM_001281463.1.
UniGeneiHs.211602.

3D structure databases

ProteinModelPortaliG8JLG1.
SMRiG8JLG1. Positions 477-653.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000323421.

Proteomic databases

PaxDbiG8JLG1.
PeptideAtlasiG8JLG1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375340; ENSP00000364489; ENSG00000072501.
GeneIDi8243.
UCSCiuc011moe.3. human.

Organism-specific databases

CTDi8243.
HGNCiHGNC:11111. SMC1A.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0018. Eukaryota.
COG1196. LUCA.
GeneTreeiENSGT00580000081569.

Miscellaneous databases

ChiTaRSiSMC1A. human.
GenomeRNAii8243.

Gene expression databases

BgeeiENSG00000072501.
ExpressionAtlasiG8JLG1. baseline and differential.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR027417. P-loop_NTPase.
IPR003395. RecF/RecN/SMC_N.
IPR024704. SMC.
IPR029683. SMC1A_metazoan.
IPR010935. SMC_hinge.
[Graphical view]
PANTHERiPTHR18937:SF170. PTHR18937:SF170. 3 hits.
PfamiPF06470. SMC_hinge. 1 hit.
PF02463. SMC_N. 1 hit.
[Graphical view]
PIRSFiPIRSF005719. SMC. 1 hit.
SMARTiSM00968. SMC_hinge. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
SSF75553. SSF75553. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiG8JLG1_HUMAN
AccessioniPrimary (citable) accession number: G8JLG1
Entry historyi
Integrated into UniProtKB/TrEMBL: January 25, 2012
Last sequence update: October 29, 2014
Last modified: September 7, 2016
This is version 38 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.