Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Toll-like receptor

Gene

EGM_19695

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Biological processi

Keywordsi

Molecular functionReceptorUniRule annotationSAAS annotation
Biological processImmunity, Inflammatory responseUniRule annotation, Innate immunityUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Toll-like receptorUniRule annotation
Gene namesi
ORF Names:EGM_19695Imported
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)Imported
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000009130 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei588 – 609HelicalUniRule annotationAdd BLAST22

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20UniRule annotationAdd BLAST20
ChainiPRO_501102023621 – 784Toll-like receptorUniRule annotationAdd BLAST764

Structurei

3D structure databases

ProteinModelPortaliG8F2Z9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini639 – 784TIRInterPro annotationAdd BLAST146

Sequence similaritiesi

Belongs to the Toll-like receptor family.UniRule annotationSAAS annotation

Keywords - Domaini

Leucine-rich repeatSAAS annotation, RepeatSAAS annotation, SignalUniRule annotation, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
3.80.10.10. 3 hits.
InterProiView protein in InterPro
IPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR032675. LRR_dom_sf.
IPR000157. TIR_dom.
IPR027185. TLR2.
IPR035897. Toll_tir_struct_dom_sf.
PANTHERiPTHR24365:SF17. PTHR24365:SF17. 1 hit.
PfamiView protein in Pfam
PF13855. LRR_8. 2 hits.
PF01463. LRRCT. 1 hit.
PF01582. TIR. 1 hit.
SMARTiView protein in SMART
SM00369. LRR_TYP. 7 hits.
SM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
SUPFAMiSSF52058. SSF52058. 2 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiView protein in PROSITE
PS51450. LRR. 11 hits.
PS50104. TIR. 1 hit.

Sequencei

Sequence statusi: Complete.

G8F2Z9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPHTLWMVWV LGVIISLSKE ESSNQASLSC DHNGICKGSS GSLNSIPSVL
60 70 80 90 100
TEAVKCLDLS NNRITYISNS DLQRYVNLQA LVLTSNGINT IEEDSFSSLG
110 120 130 140 150
RLEHLDLSYN YLSNLSSSWF KPLSSLKFLN LLGNPYKTLG ETSLFSHLTK
160 170 180 190 200
LRILRVGNMD TFTKIQRKDF AGLTFLEELE IDASDLQSYE PKSLKSIQNV
210 220 230 240 250
SHLILHMKQH ILLLEIFVDL TSSVECLELR DTDLNTFHFS ELSTGETNSL
260 270 280 290 300
IKKFTFRNVK ITDESLFQVM KLLSQISGLL ELEFDDCTLN GVGDFRGSDN
310 320 330 340 350
DRVIDPGKVE TLTIRRLHIP QFYSFNDLST LYPLTERVKR ITVENSKVFL
360 370 380 390 400
VPCLLSRHLK SLEYLDLSEN LMVEEYLKNS ACEDAWPSLQ TLILRQNHLA
410 420 430 440 450
SLGKTGETLL TLKNLTNLDI SKNTFHYMPE TCQWPEKMKY LNLSSTRIHS
460 470 480 490 500
VTGCIPKTLE ILDISNNNLN LFSLNLPQLK ELYISRNKLM TLPDASLLPM
510 520 530 540 550
LLVLKISRNT ITTFSKEQLD SFHTLKTLEA GGNNFICSCE FLSFTQEQQA
560 570 580 590 600
LAKVLADWPA NYLCDSPSHV RGQRVQDVRL SVSECHRAAL VSGMCCALFL
610 620 630 640 650
LILLMGVLCH RFHGLWYMKM MWAWLQAKRK PRKAPNRDIC YDAFVSYSER
660 670 680 690 700
DAYWVENLMV QELENFNPPF KLCLHKRDFI PGKWIIDNII DSIEKSHKTV
710 720 730 740 750
FVLSENFVKS EWCKYELDFS HFRLFDENND AAILVLLEPI EKKAIPQRFC
760 770 780
KLRKIMNTKT YLEWPMDEAR QEGFWVNLRA AIKS
Length:784
Mass (Da):90,031
Last modified:January 25, 2012 - v1
Checksum:i4169BFDEFEE1BB8E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JH330209 Genomic DNA. Translation: EHH61663.1.

Similar proteinsi

Entry informationi

Entry nameiG8F2Z9_MACFA
AccessioniPrimary (citable) accession number: G8F2Z9
Entry historyiIntegrated into UniProtKB/TrEMBL: January 25, 2012
Last sequence update: January 25, 2012
Last modified: November 22, 2017
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported