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Protein

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Gene

TPHA0E02930

Organism
Tetrapisispora phaffii (strain ATCC 24235 / CBS 4417 / NBRC 1672 / NRRL Y-8282 / UCD 70-5) (Yeast) (Fabospora phaffii)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).UniRule annotation

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (TPHA0E02930), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (TPHA0F00210)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processElectron transportUniRule annotation, Transport, Tricarboxylic acid cycleUniRule annotation
LigandFADUniRule annotation, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialUniRule annotation (EC:1.3.5.1UniRule annotation)
Gene namesi
Name:TPHA0E02930Imported
Ordered Locus Names:TPHA_0E02930Imported
OrganismiTetrapisispora phaffii (strain ATCC 24235 / CBS 4417 / NBRC 1672 / NRRL Y-8282 / UCD 70-5) (Yeast) (Fabospora phaffii)Imported
Taxonomic identifieri1071381 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeTetrapisispora
Proteomesi
  • UP000005666 Componenti: Chromosome 5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

MembraneUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi1071381.XP_003685817.1

Structurei

3D structure databases

ProteinModelPortaliG8BU05
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 446FAD_binding_2InterPro annotationAdd BLAST397
Domaini501 – 637Succ_DH_flav_CInterPro annotationAdd BLAST137

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili28 – 48Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transit peptideUniRule annotation

Phylogenomic databases

eggNOGiKOG2403 Eukaryota
COG1053 LUCA
KOiK00234
OrthoDBiEOG092C17LB

Family and domain databases

Gene3Di3.50.50.60, 2 hits
3.90.700.10, 1 hit
InterProiView protein in InterPro
IPR003953 FAD-binding_2
IPR036188 FAD/NAD-bd_sf
IPR003952 FRD_SDH_FAD_BS
IPR037099 Fum_R/Succ_DH_flav-like_C_sf
IPR015939 Fum_Rdtase/Succ_DH_flav-like_C
IPR027477 Succ_DH/fumarate_Rdtase_cat_sf
IPR011281 Succ_DH_flav_su_fwd
IPR014006 Succ_Dhase_FrdA_Gneg
PfamiView protein in Pfam
PF00890 FAD_binding_2, 1 hit
PF02910 Succ_DH_flav_C, 1 hit
SUPFAMiSSF46977 SSF46977, 1 hit
SSF51905 SSF51905, 2 hits
SSF56425 SSF56425, 1 hit
TIGRFAMsiTIGR01816 sdhA_forward, 1 hit
TIGR01812 sdhA_frdA_Gneg, 1 hit
PROSITEiView protein in PROSITE
PS00504 FRD_SDH_FAD_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

G8BU05-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLHLKRNFIN KQRSISSSLY KYTTARGLAT AKNNIDDLTS KYNLIDHEYD
60 70 80 90 100
CVVVGAGGAG LRAAFGLAEA GFKTACVSKL FPTRSHTVAA QGGINAALGN
110 120 130 140 150
VHPDNWKWHM YDTVKGSDWL GDQDSIHYMT KEAPASIIEL EHYGMPFSRL
160 170 180 190 200
PDGKIYQRAF GGQSKDYGKK GQAYRTCAVA DRTGHAMLHT LYGQALNHDT
210 220 230 240 250
HFFIEYFAMD LLTHNGEVKG IIAYNQEDGT IHRFKAHKTI IATGGYGRAY
260 270 280 290 300
FSCTSAHTCT GDGNAMVSRA GFPLQDLEFV QFHPSGIYGS GCLITEGARG
310 320 330 340 350
EGGYLINSEG ERFMERYAPT AKDLASRDVV SRAITMEINA GRGVGKNKDH
360 370 380 390 400
MLLQLSHLPP EVLKERLPGI SETASIFAGV DVTKQPIPIL PTVHYNMGGI
410 420 430 440 450
PTKYTGEALT IDEETGEDKV IPGLFACGEA ACVSVHGANR LGANSLLDLV
460 470 480 490 500
VFGRAVSHTI ADQLQPGLPH KPLPQDIGKE SLQRLDRIRN SSGKIPTADI
510 520 530 540 550
RLKMQKAMQK NVSVFRIQDT LDKGVEEVTA IDKTYKDDVH VSDRSMIWNS
560 570 580 590 600
DLVETMELEN LLTCAMQTAT SAAARKESRG AHAREDYPTR DDDHWMKHTL
610 620 630
SWQKNTGDKV DLKYRKVIYK TLDEKECPSV PPAIRSY
Length:637
Mass (Da):70,261
Last modified:January 25, 2012 - v1
Checksum:i1F7BCE4BC8C5EDAD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE612860 Genomic DNA Translation: CCE63383.1
RefSeqiXP_003685817.1, XM_003685769.1

Genome annotation databases

EnsemblFungiiCCE63383; CCE63383; TPHA_0E02930
GeneIDi11531226
KEGGitpf:TPHA_0E02930

Similar proteinsi

Entry informationi

Entry nameiG8BU05_TETPH
AccessioniPrimary (citable) accession number: G8BU05
Entry historyiIntegrated into UniProtKB/TrEMBL: January 25, 2012
Last sequence update: January 25, 2012
Last modified: March 28, 2018
This is version 34 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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