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G7WP10

- G7WP10_METH6

UniProt

G7WP10 - G7WP10_METH6

Protein

DNA ligase

Gene

lig

Organism
Methanosaeta harundinacea (strain 6Ac)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 21 (01 Oct 2014)
      Sequence version 1 (25 Jan 2012)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei248 – 2481ATPUniRule annotation
    Active sitei250 – 2501N6-AMP-lysine intermediateUniRule annotation
    Binding sitei255 – 2551ATPUniRule annotation
    Binding sitei270 – 2701ATPUniRule annotation
    Binding sitei300 – 3001ATPUniRule annotation
    Binding sitei340 – 3401ATPUniRule annotation
    Binding sitei412 – 4121ATPUniRule annotation
    Binding sitei418 – 4181ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMHAR1110509:GLGF-1487-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]UniRule annotation
    Gene namesi
    Name:ligUniRule annotation
    Ordered Locus Names:Mhar_1487Imported
    OrganismiMethanosaeta harundinacea (strain 6Ac)Imported
    Taxonomic identifieri1110509 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosaetaceaeMethanosaeta
    ProteomesiUP000005877: Chromosome

    Structurei

    3D structure databases

    ProteinModelPortaliG7WP10.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    KOiK10747.
    OMAiARVQVHK.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G7WP10-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSFESFAEL CARIEEIGGS IEKADLLASF LRDLEEEELS VVPSFVMGSP    50
    FPASSDLLLG VGPSTLYDAL SKAFGAAPSE VQELLRRTGD VGAVAAELAK 100
    KGRSSTLSTF LEGERLTILE VHSRFLLIAR ASGRRSQTAK MKHLRYLFSE 150
    AGATEARYMA RLALEDMRIG VGEGIVRDAV AKAFGISPEE VERGYNFTSD 200
    LGLVARQAKE GRLQELTIEI GRPIKMMLAQ LGSGIAGSVA EMGTAAVEVK 250
    YDGSRVQIHK RGEEVEIFSR RLERVTRSLP EIVSFVKEGV RAEAAILDGE 300
    AVARGEDGRP LPFQEILKRF RRKYRVEGAA KRIPLELMLF DLIYLNGRVL 350
    IDEPLRERRR LLESVADEKI LAGQKVTDDP EEVAGIYEEA IAEGHEGVML 400
    KSPESPYAPG KRGKNWLKIK PVMETLDLVV IGARWGEGRR ATFFGSYRLA 450
    SPDPETGRLE DVGWVATGIT DEMLAELTEL FRDLVLVAGE GMEVEVKPEV 500
    VFEVAFEEIQ KSKSYSSGYA LRFPRLVRIR DDKAVEEADT LDRVAGLYAT 550
    QRGRNGRSSG 560
    Length:560
    Mass (Da):61,779
    Last modified:January 25, 2012 - v1
    Checksum:iB700E11D4E8A4EB4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003117 Genomic DNA. Translation: AET64851.1.
    RefSeqiWP_014587035.1. NC_017527.1.
    YP_005920474.1. NC_017527.1.

    Genome annotation databases

    EnsemblBacteriaiAET64851; AET64851; Mhar_1487.
    GeneIDi12510656.
    KEGGimhi:Mhar_1487.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003117 Genomic DNA. Translation: AET64851.1 .
    RefSeqi WP_014587035.1. NC_017527.1.
    YP_005920474.1. NC_017527.1.

    3D structure databases

    ProteinModelPortali G7WP10.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AET64851 ; AET64851 ; Mhar_1487 .
    GeneIDi 12510656.
    KEGGi mhi:Mhar_1487.

    Phylogenomic databases

    KOi K10747.
    OMAi ARVQVHK.

    Enzyme and pathway databases

    BioCyci MHAR1110509:GLGF-1487-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome characteristics and predicted function of methyl-group oxidation pathway in the obligate aceticlastic methanogens, Methanosaeta spp."
      Zhu J., Zheng H., Ai G., Zhang G., Liu D., Liu X., Dong X.
      PLoS ONE 7:E36756-E36756(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 6AcImported.

    Entry informationi

    Entry nameiG7WP10_METH6
    AccessioniPrimary (citable) accession number: G7WP10
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 25, 2012
    Last sequence update: January 25, 2012
    Last modified: October 1, 2014
    This is version 21 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3