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G7WP10 (G7WP10_METH6) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 17. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
DNA ligase RuleBase RU000617 HAMAP-Rule MF_00407

EC=6.5.1.1 RuleBase RU000617 HAMAP-Rule MF_00407
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP] HAMAP-Rule MF_00407
Gene names
Name:lig HAMAP-Rule MF_00407
Ordered Locus Names:Mhar_1487 EMBL AET64851.1
OrganismMethanosaeta harundinacea (strain 6Ac) [Complete proteome] [HAMAP] EMBL AET64851.1
Taxonomic identifier1110509 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosaetaceaeMethanosaeta

Protein attributes

Sequence length560 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP-Rule MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). HAMAP-Rule MF_00407

Cofactor

Divalent metal cations By similarity. HAMAP-Rule MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family. RuleBase RU004196 HAMAP-Rule MF_00407

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site2501N6-AMP-lysine intermediate By similarity HAMAP-Rule MF_00407
Binding site2481ATP By similarity HAMAP-Rule MF_00407
Binding site2551ATP By similarity HAMAP-Rule MF_00407
Binding site2701ATP By similarity HAMAP-Rule MF_00407
Binding site3001ATP By similarity HAMAP-Rule MF_00407
Binding site3401ATP By similarity HAMAP-Rule MF_00407
Binding site4121ATP By similarity HAMAP-Rule MF_00407
Binding site4181ATP By similarity HAMAP-Rule MF_00407

Sequences

Sequence LengthMass (Da)Tools
G7WP10 [UniParc].

Last modified January 25, 2012. Version 1.
Checksum: B700E11D4E8A4EB4

FASTA56061,779
        10         20         30         40         50         60 
MTSFESFAEL CARIEEIGGS IEKADLLASF LRDLEEEELS VVPSFVMGSP FPASSDLLLG 

        70         80         90        100        110        120 
VGPSTLYDAL SKAFGAAPSE VQELLRRTGD VGAVAAELAK KGRSSTLSTF LEGERLTILE 

       130        140        150        160        170        180 
VHSRFLLIAR ASGRRSQTAK MKHLRYLFSE AGATEARYMA RLALEDMRIG VGEGIVRDAV 

       190        200        210        220        230        240 
AKAFGISPEE VERGYNFTSD LGLVARQAKE GRLQELTIEI GRPIKMMLAQ LGSGIAGSVA 

       250        260        270        280        290        300 
EMGTAAVEVK YDGSRVQIHK RGEEVEIFSR RLERVTRSLP EIVSFVKEGV RAEAAILDGE 

       310        320        330        340        350        360 
AVARGEDGRP LPFQEILKRF RRKYRVEGAA KRIPLELMLF DLIYLNGRVL IDEPLRERRR 

       370        380        390        400        410        420 
LLESVADEKI LAGQKVTDDP EEVAGIYEEA IAEGHEGVML KSPESPYAPG KRGKNWLKIK 

       430        440        450        460        470        480 
PVMETLDLVV IGARWGEGRR ATFFGSYRLA SPDPETGRLE DVGWVATGIT DEMLAELTEL 

       490        500        510        520        530        540 
FRDLVLVAGE GMEVEVKPEV VFEVAFEEIQ KSKSYSSGYA LRFPRLVRIR DDKAVEEADT 

       550        560 
LDRVAGLYAT QRGRNGRSSG 

« Hide

References

[1]"The Genome Characteristics and Predicted Function of Methyl-Group Oxidation Pathway in the Obligate Aceticlastic Methanogens, Methanosaeta spp."
Zhu J., Zheng H., Ai G., Zhang G., Liu D., Liu X., Dong X.
PLoS ONE 7:E36756-E36756(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 6Ac EMBL AET64851.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP003117 Genomic DNA. Translation: AET64851.1.
RefSeqYP_005920474.1. NC_017527.1.

3D structure databases

ProteinModelPortalG7WP10.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAET64851; AET64851; Mhar_1487.
GeneID12510656.
KEGGmhi:Mhar_1487.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK10747.
OMAGRPRPFQ.

Enzyme and pathway databases

BioCycMHAR1110509:GLGF-1487-MONOMER.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPMF_00407. DNA_ligase.
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG7WP10_METH6
AccessionPrimary (citable) accession number: G7WP10
Entry history
Integrated into UniProtKB/TrEMBL: January 25, 2012
Last sequence update: January 25, 2012
Last modified: April 16, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)