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G7WP10

- G7WP10_METH6

UniProt

G7WP10 - G7WP10_METH6

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Protein

DNA ligase

Gene
lig, Mhar_1487
Organism
Methanosaeta harundinacea (strain 6Ac)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei248 – 2481ATP By similarityUniRule annotation
Active sitei250 – 2501N6-AMP-lysine intermediate By similarityUniRule annotation
Binding sitei255 – 2551ATP By similarityUniRule annotation
Binding sitei270 – 2701ATP By similarityUniRule annotation
Binding sitei300 – 3001ATP By similarityUniRule annotation
Binding sitei340 – 3401ATP By similarityUniRule annotation
Binding sitei412 – 4121ATP By similarityUniRule annotation
Binding sitei418 – 4181ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA ligation involved in DNA repair Source: InterPro
  4. DNA recombination Source: UniProtKB-HAMAP
  5. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciMHAR1110509:GLGF-1487-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Mhar_1487Imported
OrganismiMethanosaeta harundinacea (strain 6Ac)Imported
Taxonomic identifieri1110509 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosaetaceaeMethanosaeta
ProteomesiUP000005877: Chromosome

Structurei

3D structure databases

ProteinModelPortaliG7WP10.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK10747.
OMAiARVQVHK.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G7WP10-1 [UniParc]FASTAAdd to Basket

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MTSFESFAEL CARIEEIGGS IEKADLLASF LRDLEEEELS VVPSFVMGSP    50
FPASSDLLLG VGPSTLYDAL SKAFGAAPSE VQELLRRTGD VGAVAAELAK 100
KGRSSTLSTF LEGERLTILE VHSRFLLIAR ASGRRSQTAK MKHLRYLFSE 150
AGATEARYMA RLALEDMRIG VGEGIVRDAV AKAFGISPEE VERGYNFTSD 200
LGLVARQAKE GRLQELTIEI GRPIKMMLAQ LGSGIAGSVA EMGTAAVEVK 250
YDGSRVQIHK RGEEVEIFSR RLERVTRSLP EIVSFVKEGV RAEAAILDGE 300
AVARGEDGRP LPFQEILKRF RRKYRVEGAA KRIPLELMLF DLIYLNGRVL 350
IDEPLRERRR LLESVADEKI LAGQKVTDDP EEVAGIYEEA IAEGHEGVML 400
KSPESPYAPG KRGKNWLKIK PVMETLDLVV IGARWGEGRR ATFFGSYRLA 450
SPDPETGRLE DVGWVATGIT DEMLAELTEL FRDLVLVAGE GMEVEVKPEV 500
VFEVAFEEIQ KSKSYSSGYA LRFPRLVRIR DDKAVEEADT LDRVAGLYAT 550
QRGRNGRSSG 560
Length:560
Mass (Da):61,779
Last modified:January 25, 2012 - v1
Checksum:iB700E11D4E8A4EB4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003117 Genomic DNA. Translation: AET64851.1.
RefSeqiWP_014587035.1. NC_017527.1.
YP_005920474.1. NC_017527.1.

Genome annotation databases

EnsemblBacteriaiAET64851; AET64851; Mhar_1487.
GeneIDi12510656.
KEGGimhi:Mhar_1487.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003117 Genomic DNA. Translation: AET64851.1 .
RefSeqi WP_014587035.1. NC_017527.1.
YP_005920474.1. NC_017527.1.

3D structure databases

ProteinModelPortali G7WP10.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AET64851 ; AET64851 ; Mhar_1487 .
GeneIDi 12510656.
KEGGi mhi:Mhar_1487.

Phylogenomic databases

KOi K10747.
OMAi ARVQVHK.

Enzyme and pathway databases

BioCyci MHAR1110509:GLGF-1487-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The Genome Characteristics and Predicted Function of Methyl-Group Oxidation Pathway in the Obligate Aceticlastic Methanogens, Methanosaeta spp."
    Zhu J., Zheng H., Ai G., Zhang G., Liu D., Liu X., Dong X.
    PLoS ONE 7:E36756-E36756(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 6AcImported.

Entry informationi

Entry nameiG7WP10_METH6
AccessioniPrimary (citable) accession number: G7WP10
Entry historyi
Integrated into UniProtKB/TrEMBL: January 25, 2012
Last sequence update: January 25, 2012
Last modified: September 3, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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