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Protein

DNA ligase

Gene

lig

Organism
Methanosaeta harundinacea (strain 6Ac)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei248ATPUniRule annotation1
Active sitei250N6-AMP-lysine intermediateUniRule annotation1
Binding sitei255ATPUniRule annotation1
Binding sitei270ATPUniRule annotation1
Binding sitei300ATPUniRule annotation1
Binding sitei340ATPUniRule annotation1
Binding sitei412ATPUniRule annotation1
Binding sitei418ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processCell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Mhar_1487Imported
OrganismiMethanosaeta harundinacea (strain 6Ac)Imported
Taxonomic identifieri1110509 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosaetaceaeMethanothrix
Proteomesi
  • UP000005877 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi1110509.Mhar_1487

Structurei

3D structure databases

ProteinModelPortaliG7WP10
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini328 – 453DNA_LIGASE_A3InterPro annotationAdd BLAST126

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01347 Archaea
COG1793 LUCA
KOiK10747
OMAiWLFEESY
OrthoDBiPOG093Z03L0

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
HAMAPiMF_00407 DNA_ligase, 1 hit
InterProiView protein in InterPro
IPR022865 DNA_ligae_ATP-dep_bac/arc
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

G7WP10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSFESFAEL CARIEEIGGS IEKADLLASF LRDLEEEELS VVPSFVMGSP
60 70 80 90 100
FPASSDLLLG VGPSTLYDAL SKAFGAAPSE VQELLRRTGD VGAVAAELAK
110 120 130 140 150
KGRSSTLSTF LEGERLTILE VHSRFLLIAR ASGRRSQTAK MKHLRYLFSE
160 170 180 190 200
AGATEARYMA RLALEDMRIG VGEGIVRDAV AKAFGISPEE VERGYNFTSD
210 220 230 240 250
LGLVARQAKE GRLQELTIEI GRPIKMMLAQ LGSGIAGSVA EMGTAAVEVK
260 270 280 290 300
YDGSRVQIHK RGEEVEIFSR RLERVTRSLP EIVSFVKEGV RAEAAILDGE
310 320 330 340 350
AVARGEDGRP LPFQEILKRF RRKYRVEGAA KRIPLELMLF DLIYLNGRVL
360 370 380 390 400
IDEPLRERRR LLESVADEKI LAGQKVTDDP EEVAGIYEEA IAEGHEGVML
410 420 430 440 450
KSPESPYAPG KRGKNWLKIK PVMETLDLVV IGARWGEGRR ATFFGSYRLA
460 470 480 490 500
SPDPETGRLE DVGWVATGIT DEMLAELTEL FRDLVLVAGE GMEVEVKPEV
510 520 530 540 550
VFEVAFEEIQ KSKSYSSGYA LRFPRLVRIR DDKAVEEADT LDRVAGLYAT
560
QRGRNGRSSG
Length:560
Mass (Da):61,779
Last modified:January 25, 2012 - v1
Checksum:iB700E11D4E8A4EB4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003117 Genomic DNA Translation: AET64851.1
RefSeqiWP_014587035.1, NC_017527.1

Genome annotation databases

EnsemblBacteriaiAET64851; AET64851; Mhar_1487
GeneIDi12510656
KEGGimhi:Mhar_1487
PATRICifig|1110509.7.peg.1662

Similar proteinsi

Entry informationi

Entry nameiG7WP10_METH6
AccessioniPrimary (citable) accession number: G7WP10
Entry historyiIntegrated into UniProtKB/TrEMBL: January 25, 2012
Last sequence update: January 25, 2012
Last modified: March 28, 2018
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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