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Protein

Thymidine kinase

Gene

tdk

Organism
Leuconostoc mesenteroides subsp. mesenteroides J18
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei98 – 981Proton acceptorUniRule annotation
Metal bindingi155 – 1551ZincUniRule annotation
Metal bindingi158 – 1581ZincUniRule annotation
Metal bindingi192 – 1921ZincUniRule annotation
Metal bindingi195 – 1951ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi20 – 278ATPUniRule annotation
Nucleotide bindingi97 – 1004ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciLMES1107880:GLFP-1595-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
ORF Names:MI1_07745Imported
OrganismiLeuconostoc mesenteroides subsp. mesenteroides J18Imported
Taxonomic identifieri1107880 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLeuconostocaceaeLeuconostoc
ProteomesiUP000005875: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliG7VK75.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

KOiK00857.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G7VK75-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFSIARKHSK NMAQLFFEYG AMSSGKSIEI LKVAHNYESQ GRKVLLMTPI
60 70 80 90 100
MDTRAGVGVV ASRIGLSREA VAVQPEDDLY HLIKGMKDDH LAVVLIDEAQ
110 120 130 140 150
FLAAKQVDQL AYVVDHLNIP VMTFGLKQDA FNHLFEGSKR LIELADKLEE
160 170 180 190 200
MKTICSFCGK KATTQLRIVD GKPQREGAQV FIGGDEAYIP TCRHHWFKPD
210
LDKITEMFPV K
Length:211
Mass (Da):23,725
Last modified:January 25, 2012 - v1
Checksum:i6E579FC33BC1DE40
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003101 Genomic DNA. Translation: AET30991.1.
RefSeqiWP_011680382.1. NC_016805.1.
YP_005174957.1. NC_016805.1.

Genome annotation databases

EnsemblBacteriaiAET30991; AET30991; MI1_07745.
GeneIDi11807969.
KEGGilmm:MI1_07745.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003101 Genomic DNA. Translation: AET30991.1.
RefSeqiWP_011680382.1. NC_016805.1.
YP_005174957.1. NC_016805.1.

3D structure databases

ProteinModelPortaliG7VK75.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAET30991; AET30991; MI1_07745.
GeneIDi11807969.
KEGGilmm:MI1_07745.

Phylogenomic databases

KOiK00857.

Enzyme and pathway databases

BioCyciLMES1107880:GLFP-1595-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete Genome Sequence of Leuconostoc mesenteroides subsp. mesenteroides Strain J18, Isolated from Kimchi."
    Jung J.Y., Lee S.H., Lee S.H., Jeon C.O.
    J. Bacteriol. 194:730-731(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J18Imported.

Entry informationi

Entry nameiG7VK75_LEUME
AccessioniPrimary (citable) accession number: G7VK75
Entry historyi
Integrated into UniProtKB/TrEMBL: January 25, 2012
Last sequence update: January 25, 2012
Last modified: January 7, 2015
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.