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G7V8G0 (G7V8G0_THELD) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 16. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:Tlie_0587 EMBL AER66322.1
OrganismThermovirga lienii (strain ATCC BAA-1197 / DSM 17291 / Cas60314) [Complete proteome] [HAMAP] EMBL AER66322.1
Taxonomic identifier580340 [NCBI]
Taxonomic lineageBacteriaSynergistetesSynergistiaSynergistalesSynergistaceaeThermovirga

Protein attributes

Sequence length319 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain107 – 312206ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding139 – 19456ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2661Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2791Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2791Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2811Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
G7V8G0 [UniParc].

Last modified January 25, 2012. Version 1.
Checksum: 1FF2E4D715DA3B01

FASTA31934,818
        10         20         30         40         50         60 
MEMLKNVKIG VIYGGDSPER EVSLASGTAV LKALEELDLK VEPLLVSSAL DAVSKVQSSR 

        70         80         90        100        110        120 
CDVFFVALHG SWGEDGRLQG ALDLLGKKYT GSGHESCALA MDKRVSKAIF ESCKIPTAPY 

       130        140        150        160        170        180 
VVLQRDKFLG NLNQKLEELL CLWQAVVVKP SGCGSTVGVT IARDVETICK GIREASQYDQ 

       190        200        210        220        230        240 
VLLVEKYIPG REITVTVWEE EGKVEALPIV EIIPKEGFYD YRAKYTSGIT RYQCPADLPD 

       250        260        270        280        290        300 
EVGARVKEVA VASHLALGCR VYSRVDIRLS EDGTPYVLEV NTAPGMTATS LVPKAASAMG 

       310 
WSFPELVARI VINSLRKYK 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP003096 Genomic DNA. Translation: AER66322.1.
RefSeqYP_004932419.1. NC_016148.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAER66322; AER66322; Tlie_0587.
GeneID11376371.
KEGGtli:Tlie_0587.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.

Enzyme and pathway databases

BioCycTLIE580340:GH7T-604-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG7V8G0_THELD
AccessionPrimary (citable) accession number: G7V8G0
Entry history
Integrated into UniProtKB/TrEMBL: January 25, 2012
Last sequence update: January 25, 2012
Last modified: February 19, 2014
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)