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Protein

Alanine racemase

Gene

Tlie_1283

Organism
Thermovirga lienii (strain ATCC BAA-1197 / DSM 17291 / Cas60314)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei37 – 371Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei135 – 1351SubstrateUniRule annotation
Active sitei264 – 2641Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei312 – 3121Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciTLIE580340:GH7T-1336-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Tlie_1283Imported
OrganismiThermovirga lienii (strain ATCC BAA-1197 / DSM 17291 / Cas60314)Imported
Taxonomic identifieri580340 [NCBI]
Taxonomic lineageiBacteriaSynergistetesSynergistiaSynergistalesSynergistaceaeThermovirga
ProteomesiUP000005868: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei37 – 371N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliG7V627.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.

Sequencei

Sequence statusi: Complete.

G7V627-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNFRPTRMEV NLENIKHNFL QVKGLLKEKS QIIGVVKANG YGMGMVQVAK
60 70 80 90 100
TLIEAGCSRL AVATPDEAII LRENGIYLPL LVLGPSPASV AEEYVNKDIS
110 120 130 140 150
STITDLSFAD ALSKAAIDLG KRARVHIKVD TGMGRIGFLP EEVPEVVERL
160 170 180 190 200
LLMKGLEIEG IFTHFATADE RNGSYTETQF KRFCDVLDVL RTKNVHFRLR
210 220 230 240 250
HCCNSAGTLN FSHMHMDAVR PGIILYGMWP SEWCKKKIKL KRAFKVVTAV
260 270 280 290 300
ACVRTLPQGS GISYGLRYMT RGEERIAVLP IGYHDGYPRS LSMKTEVLIK
310 320 330 340 350
GQRAPIVGNI CMDQTMVDVT HIPDVKVGDE VVLVGPQGNE EITPEEIAKH
360 370
LGTINYEIPN LFTPRVPRVY V
Length:371
Mass (Da):41,290
Last modified:January 25, 2012 - v1
Checksum:i5CC1D8BC2D29F8E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003096 Genomic DNA. Translation: AER67014.1.
RefSeqiYP_004933111.1. NC_016148.1.

Genome annotation databases

EnsemblBacteriaiAER67014; AER67014; Tlie_1283.
GeneIDi11377750.
KEGGitli:Tlie_1283.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003096 Genomic DNA. Translation: AER67014.1.
RefSeqiYP_004933111.1. NC_016148.1.

3D structure databases

ProteinModelPortaliG7V627.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAER67014; AER67014; Tlie_1283.
GeneIDi11377750.
KEGGitli:Tlie_1283.

Phylogenomic databases

KOiK01775.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciTLIE580340:GH7T-1336-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1197 / DSM 17291 / Cas60314Imported.

Entry informationi

Entry nameiG7V627_THELD
AccessioniPrimary (citable) accession number: G7V627
Entry historyi
Integrated into UniProtKB/TrEMBL: January 25, 2012
Last sequence update: January 25, 2012
Last modified: February 4, 2015
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.