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G7V627

- G7V627_THELD

UniProt

G7V627 - G7V627_THELD

Protein

Alanine racemase

Gene

Tlie_1283

Organism
Thermovirga lienii (strain ATCC BAA-1197 / DSM 17291 / Cas60314)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 22 (01 Oct 2014)
      Sequence version 1 (25 Jan 2012)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei37 – 371Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei135 – 1351SubstrateUniRule annotation
    Active sitei264 – 2641Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei312 – 3121Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciTLIE580340:GH7T-1336-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Ordered Locus Names:Tlie_1283Imported
    OrganismiThermovirga lienii (strain ATCC BAA-1197 / DSM 17291 / Cas60314)Imported
    Taxonomic identifieri580340 [NCBI]
    Taxonomic lineageiBacteriaSynergistetesSynergistiaSynergistalesSynergistaceaeThermovirga
    ProteomesiUP000005868: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei37 – 371N6-(pyridoxal phosphate)lysineUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliG7V627.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    KOiK01775.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    G7V627-1 [UniParc]FASTAAdd to Basket

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    MNFRPTRMEV NLENIKHNFL QVKGLLKEKS QIIGVVKANG YGMGMVQVAK    50
    TLIEAGCSRL AVATPDEAII LRENGIYLPL LVLGPSPASV AEEYVNKDIS 100
    STITDLSFAD ALSKAAIDLG KRARVHIKVD TGMGRIGFLP EEVPEVVERL 150
    LLMKGLEIEG IFTHFATADE RNGSYTETQF KRFCDVLDVL RTKNVHFRLR 200
    HCCNSAGTLN FSHMHMDAVR PGIILYGMWP SEWCKKKIKL KRAFKVVTAV 250
    ACVRTLPQGS GISYGLRYMT RGEERIAVLP IGYHDGYPRS LSMKTEVLIK 300
    GQRAPIVGNI CMDQTMVDVT HIPDVKVGDE VVLVGPQGNE EITPEEIAKH 350
    LGTINYEIPN LFTPRVPRVY V 371
    Length:371
    Mass (Da):41,290
    Last modified:January 25, 2012 - v1
    Checksum:i5CC1D8BC2D29F8E8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003096 Genomic DNA. Translation: AER67014.1.
    RefSeqiWP_014163430.1. NC_016148.1.
    YP_004933111.1. NC_016148.1.

    Genome annotation databases

    EnsemblBacteriaiAER67014; AER67014; Tlie_1283.
    GeneIDi11377750.
    KEGGitli:Tlie_1283.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003096 Genomic DNA. Translation: AER67014.1 .
    RefSeqi WP_014163430.1. NC_016148.1.
    YP_004933111.1. NC_016148.1.

    3D structure databases

    ProteinModelPortali G7V627.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AER67014 ; AER67014 ; Tlie_1283 .
    GeneIDi 11377750.
    KEGGi tli:Tlie_1283.

    Phylogenomic databases

    KOi K01775.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci TLIE580340:GH7T-1336-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-1197 / DSM 17291 / Cas60314Imported.

    Entry informationi

    Entry nameiG7V627_THELD
    AccessioniPrimary (citable) accession number: G7V627
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 25, 2012
    Last sequence update: January 25, 2012
    Last modified: October 1, 2014
    This is version 22 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3