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Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

PAGR_g3454

Organism
Pantoea ananatis PA13
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

Catalytic activityi

Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • (R)-lipoateUniRule annotationNote: Binds 1 lipoyl cofactor covalently.UniRule annotation
  • (R)-lipoateUniRule annotationNote: Binds 2 lipoyl cofactors covalently.UniRule annotation
  • (R)-lipoateUniRule annotationNote: Binds 3 lipoyl cofactors covalently.UniRule annotation

GO - Molecular functioni

  1. dihydrolipoyllysine-residue acetyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseUniRule annotation, Transferase

Keywords - Biological processi

GlycolysisUniRule annotation

Keywords - Ligandi

PyruvateImported

Enzyme and pathway databases

BioCyciPANA1095774:GLIA-3533-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
Gene namesi
ORF Names:PAGR_g3454Imported
OrganismiPantoea ananatis PA13Imported
Taxonomic identifieri1095774 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePantoea
ProteomesiUP000005872: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. pyruvate dehydrogenase complex Source: InterPro
Complete GO annotation...

Interactioni

Subunit structurei

Forms a 24-polypeptide structural core with octahedral symmetry.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliG7UGQ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation
Contains 3 lipoyl-binding domains.UniRule annotation

Keywords - Domaini

LipoylUniRule annotationSAAS annotation

Phylogenomic databases

KOiK00627.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR006256. AcTrfase_Pyrv_DH_cplx.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 3 hits.
PF02817. E3_binding. 1 hit.
[Graphical view]
SUPFAMiSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 3 hits.
TIGRFAMsiTIGR01348. PDHac_trf_long. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 3 hits.
PS00189. LIPOYL. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G7UGQ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIEIKVPDI GSDEVEVTEI LVKVGDKVEA EQSLITVEGD KASMEVPSPQ
60 70 80 90 100
AGVVKEIKIA TGDKVETGSL IMMFDAEGAA EAAPAAAEEK KADAAPAPAA
110 120 130 140 150
AAATASKEVA VPDIGGDEVE VTEILVKVGD KVEAEQSLIV VEGDKASMEV
160 170 180 190 200
PAPFAGVVKE ITIATGDKVS TGSAIMVFEA EGAAPASDAK PEVKEEAASA
210 220 230 240 250
PAAAAGAKDV NVPDIGGDEV EVTEILVKVG DKVEAEQSLI VVEGDKASME
260 270 280 290 300
VPAPFAGIVK ELKVATGDKV STGSLIMVFE VEGAAPAAPA AAKQEAAPAP
310 320 330 340 350
AAKSEAKAAA APAAAKTESK GEFAENDAYV HATPVIRRLA REFGVNLAKV
360 370 380 390 400
KGTGRKGRIL KEDVQAYVKD AVKRAEAAPA AASGGGLPGM LPWPKVDFSK
410 420 430 440 450
FGEVEEVELG RIQKISGANL SRNWVMIPHV THFDKTDITE LEAFRKQQNA
460 470 480 490 500
EAEKRKLDVK YTPVVFIMKA VAAALEQMPR FNSSLSEDAQ KLTLKKYINI
510 520 530 540 550
GVAVDTPNGL VVPVFKDVNK KGITELSREL MAISKKARDG KLTAGDMQGG
560 570 580 590 600
CFTISSLGGL GTTHFAPIVN APEVAILGVS KSAMEPVWNG KEFAPRLMMP
610 620 630
ISLSFDHRVI DGADGARFIT IIGNMLSDIR RLVM
Length:634
Mass (Da):66,259
Last modified:January 25, 2012 - v1
Checksum:i44B954C309569083
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003085 Genomic DNA. Translation: AER33946.1.
RefSeqiYP_005994166.1. NC_017554.1.

Genome annotation databases

EnsemblBacteriaiAER33946; AER33946; PAGR_g3454.
GeneIDi12585134.
KEGGipaq:PAGR_g3454.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003085 Genomic DNA. Translation: AER33946.1.
RefSeqiYP_005994166.1. NC_017554.1.

3D structure databases

ProteinModelPortaliG7UGQ6.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAER33946; AER33946; PAGR_g3454.
GeneIDi12585134.
KEGGipaq:PAGR_g3454.

Phylogenomic databases

KOiK00627.

Enzyme and pathway databases

BioCyciPANA1095774:GLIA-3533-MONOMER.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR006256. AcTrfase_Pyrv_DH_cplx.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 3 hits.
PF02817. E3_binding. 1 hit.
[Graphical view]
SUPFAMiSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 3 hits.
TIGRFAMsiTIGR01348. PDHac_trf_long. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 3 hits.
PS00189. LIPOYL. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete Genome Sequence of the Rice Pathogen Pantoea ananatis Strain PA13."
    Choi O., Lim J.Y., Seo Y.S., Hwang I., Kim J.
    J. Bacteriol. 194:531-531(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PA13Imported.

Entry informationi

Entry nameiG7UGQ6_PANAN
AccessioniPrimary (citable) accession number: G7UGQ6
Entry historyi
Integrated into UniProtKB/TrEMBL: January 25, 2012
Last sequence update: January 25, 2012
Last modified: January 7, 2015
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.